Predictive value of thyroid-stimulating hormone in postmenopausal type 2 diabetes mellitus patients with normal thyroid function associated with ultrasound-diagnosed non-alcoholic fatty liver disease

Du, Yiqi; Pan, Tianrong; Zhong, Xing; Liu, Nina; Zhang, Qiu

doi:10.1080/26895293.2022.2035827

Cited by 1 publication

(1 citation statement)

References 28 publications

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“…High-density lipoprotein cholesterol (HDL-C), LDL-C, total cholesterol (TC), triglyceride (TG) and fasting C peptide (FCP) were also observed from blood samples. Insulin resistance was calculated according to the HOMA-IR by 1.5 + FBG (mmol/L) × FCP (pmol/L)/2800 [ 18 ]. These measurements were conducted in The First Affiliated Hospital of USTC, Center Laboratory for medical usage.…”

Section: Methodsmentioning

confidence: 99%

The mediating role of HbA1c in the association between elevated low-density lipoprotein cholesterol levels and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus

et al. 2023

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Background Increased levels of low-density lipoprotein cholesterol (LDL-C) have been identified as one potential risk factor for diabetic peripheral neuropathy (DPN) in patients. The current study seeks to clarify the link between LDL-C, hyperglycemia, and DPN in patients with type 2 diabetes mellitus (T2DM). Methods Here, a total of 120 T2DM individuals were recruited. These volunteers with T2DM were divided into 2 groups, based on the presence or absence of peripheral neuropathy. Additionally, their baseline characteristics were compared. Association among LDL-C and glycosylated hemoglobin (HbA1c) levels and DPN, particularly with respect to specific nerve conduction velocity were analyzed. To identify factors influencing DPN, regression was performed. Furthermore, mediation analysis was employed to evaluate the indirect, direct and total effects of LDL-C on specific nerve conduction velocity, with HbA1c serving as a mediator. Results Compared to 55 patients without DPN, 65 patients with DPN demonstrated elevated levels of LDL-C and HbA1c. Both LDL-C and HbA1c have been found to be associated with reduced the motor fiber conduction velocities of Ulnar (or the Common peroneal) nerve in diabetic patients. HbA1c is one of the known risk factors for DPN in individuals with T2DM. Further mediation analysis revealed that the effect of LDL-C on the Ulnar (or the Common peroneal) nerve motor fiber conduction velocities are fully mediated by HbA1c in patients with T2DM. Conclusions The impact of elevated LDL-C levels upon the Ulnar (or the Common peroneal) nerve motor fiber conduction velocities in patients with T2DM was found to be entirely mediated by increased HbA1c levels.

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Section: Methodsmentioning

confidence: 99%