Predictive Value of the Serum Albumin Level on Admission in Patients With Spontaneous Subarachnoid Hemorrhage

Abstract

Objective: To determine the effect of the serum albumin level on admission in patients with spontaneous subarachnoid hemorrhage (SAH).Methods: A total of 229 patients with SAH were divided into control and hypoalbuminemia groups. The serum albumin levels were measured. The data, including age, gender, co-existing medical conditions, risk factors, Hunt-Hess (H-H) grade on admission, Glasgow coma score (GCS) on admission, complications during hospitalizations, length of hospital stay, length of intensive care unit (ICU) stay, in-hospital mortality, survival rate, outcome at discharge, and the 6-month follow-up outcome, were compared between the two groups.Results: Older age, an increased number of patients who consumed an excess of alcohol, and a lower GCS on admission were findings in the hypoalbuminemia group compared to the control group (p < 0.001). The ratio of patients with H-H grade I on admission in the hypoalbuminemia group was decreased compared to the control group (p < 0.05). Patients with hypoalbuminemia were more likely to be intubated, and have pneumonia and cerebral vasospasm than patients with a normal albumin level on admission (p < 0.001). Furthermore, the length of hospital and ICU stays were longer in the hypoalbuminemia group than the control group (p < 0.001). Hypoalbuminemia on admission significantly increased poor outcomes at discharge (p < 0.001). The number of patients with severe disability was increased and the recovery rate was decreased with respect to in-hospital outcomes in the hypoalbuminemia group than the control group (p < 0.001).Conclusion: Hypoalbuminemia was shown to be associated with a poor prognosis in patients with SAH.

D-dimer/albumin ratio is a prognostic marker for patients with aneurysmal subarachnoid hemorrhage-retrospective research

“…Hypoalbuminemia are common in patients with aSAH and are independently associated with a poor prognosis [5].Similarly, we had observed a negative correlation between albumin concentration and clinical outcome, which was in consistent with former studies [11,12]. Hypoproteinemia in patients with aSAH may be caused by systemic in ammation, malnutrition and active catabolic metabolism.…”

Stroke Proteomics: From Discovery to Diagnostic and Therapeutic Applications

“…Induction of hyperglycemia in rats led to augmented neuronal apoptosis 12 and 24 hours after ICH, which was accompanied by a reduction in albumin and other DEPs. 49 Low serum albumin levels were associated with poor functional outcome in patients with SAH, ICH, and IS [50][51][52] by increasing Datasets were derived from the following studies: ischemia, 4-26 intracerebral hemorrhage (ICH). 6,[27][28][29][30] Only DEPs that were identified in at least 2 proteomics studies were considered for analysis (Table S3, n=293 for ischemia and n=47 for ICH).…”

“RAISE”ing a Score to Predict Prolonged Mechanical Ventilation Following Subarachnoid Hemorrhage

“…Rass et al (1) substantiate the inclusion of the APS owing to a likely systemic inflammatory response post-SAH wherein the lack of account of the concomitant serum albumin levels draws peculiar attention, appropriate to the aforementioned context (1). Ahead of the inflammatory association of hypoalbuminemia, the latter entails dose-dependent poor clinical outcomes in the critically ill (2). Even from a strict neurocritical perspective, Shang et al (2) in a retrospective study of 229 patients demonstrated a higher predilection for intubation, pneumonia and cerebral vasospasm, in the SAH subset with hypoalbuminemia ( n = 150) in comparison to the subset with normoalbuminemia ( n = 79) (43.6% vs 8.9%, p < 0.001; 46.3% vs 13.9%, p < 0.001; 50.7% vs 32.9%, p = 0.010, respectively).…”

“…Ahead of the inflammatory association of hypoalbuminemia, the latter entails dose-dependent poor clinical outcomes in the critically ill (2). Even from a strict neurocritical perspective, Shang et al (2) in a retrospective study of 229 patients demonstrated a higher predilection for intubation, pneumonia and cerebral vasospasm, in the SAH subset with hypoalbuminemia ( n = 150) in comparison to the subset with normoalbuminemia ( n = 79) (43.6% vs 8.9%, p < 0.001; 46.3% vs 13.9%, p < 0.001; 50.7% vs 32.9%, p = 0.010, respectively). This translated as a protracted length of stay-ICU (LOS-ICU) and length of stay-hospital in their patients with hypoalbuminemia (2).…”

“…Even from a strict neurocritical perspective, Shang et al (2) in a retrospective study of 229 patients demonstrated a higher predilection for intubation, pneumonia and cerebral vasospasm, in the SAH subset with hypoalbuminemia ( n = 150) in comparison to the subset with normoalbuminemia ( n = 79) (43.6% vs 8.9%, p < 0.001; 46.3% vs 13.9%, p < 0.001; 50.7% vs 32.9%, p = 0.010, respectively). This translated as a protracted length of stay-ICU (LOS-ICU) and length of stay-hospital in their patients with hypoalbuminemia (2). With the presence of hypoalbuminemia in almost every two out of three patients, it emerged as an independent predictor for the need of intubation in the Shang et al (2) setting (odds ratio, 4.7; 95% CI, 1.67–16; p = 0.006) post-adjustment for age, gender, H&H grade, alcohol consumption, coronary artery disease, and Glasgow coma scores (2).…”