Predictive Value of the Pretreatment Extent of Disease System in Hepatoblastoma: Results From the International Society of Pediatric Oncology Liver Tumor Study Group SIOPEL-1 Study

Aronson, Daniël C.; Schnater, J. Marco; Staalman, C. R.; Weverling, Gerrit Jan; Plaschkes, J.; Perilongo, Giorgio; Brown, Julia; Phillips, Angela; Otte, Jean-Bernard; Czauderna, Piotr; MacKinlay, Gordon A.; Vos, A.

doi:10.1200/jco.2005.07.145

Cited by 194 publications

(153 citation statements)

References 17 publications

(18 reference statements)

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“…All groups contributed to HB management collecting data that have been used to associate clinical characteristics with different disease outcomes. Some characteristics that predict for worse outcomes, the 'poor' prognostic factors, have been identified across groups, such as metastatic disease at enrollment [12][13][14][15]; however, some risk factors achieved statistical significance in certain group studies, while remaining non-significant in others [12][13][14][15].…”

Section: Prevalence and Clinical Features Of Hepatoblastomasmentioning

confidence: 99%

The genetic and epigenetic landscapes of hepatoblastomas

et al. 2017

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Primary liver cancers are rare in children, and the most common type is hepatoblastoma (HB), an embryonal tumor with histological features that resemble different stages of liver cell differentiation. However, mainly because of its rarity, molecular data on HB tumorigenesis remain scarce. This article reviews the current knowledge regarding genetic and epigenetic alterations reported in HB cases, with emphasis on the recent findings of next-generation sequencing studies.

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Section: Prevalence and Clinical Features Of Hepatoblastomasmentioning

confidence: 99%

The genetic and epigenetic landscapes of hepatoblastomas

et al. 2017

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“…A lettering system further indicates extrahepatic involvement. This staging system has been useful in determining treatment plans and offers good prognostic value for overall and disease-free survival outcomes [41,42].…”

Section: Stagingmentioning

confidence: 99%

Liver Tumors in Children

2008

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After completing this course, the reader should be able to:1. Describe the current epidemiologic trends in hepatoblastoma.2. Identify the genetic syndromes that are seen in a subset of liver tumors.3. Assess the need for complete tumor resection in the treatment of liver tumors in children as well as the increasingly important option of liver transplantation for those patients with unresectable tumors.4. Discuss the impact of the hepatitis vaccine in reducing the incidence of hepatocellular carcinoma.5. Explain the prognostic impact of different histologic subtypes of hepatoblastoma.6. Promote the need for future clinical trials in testing new agents for hepatocellular carcinoma in children.7. Employ the different staging systems used in liver tumors, including the traditional North American postsurgical staging system and the European presurgical staging system using imaging.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACT

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“…The samples from inked margins of resection and gross vascular involvement (portal vein or hepatic vein-inferior vena cava) should be submitted, and the site and extent of macroscopic vascular invasion should be carefully documented. In our attempts to validate the preoperative PRETEXT and POST-TEXT grouping of the tumor, the pathologist should document which Couinaud segments of the liver are pathologically involved by the tumor 79 (Figures 5 and 6). In multifocal tumors, the size and segment location of all tumor nodules should be reported; this is especially important in helping to identify the location of any nodules found on pathologic evaluation that were not radiographically apparent on preoperative imaging.…”

Section: Immunohistochemistry and Other Ancillary Studiesmentioning

confidence: 99%

Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium

Alaggio²,

et al. 2014

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Liver tumors are rare in children, and their diagnoses may be challenging particularly because of the lack of a current consensus classification system. Systematic central histopathological review of these tumors performed as part of the pediatric collaborative therapeutic protocols has allowed the identification of histologic subtypes with distinct clinical associations. As a result, histopathology has been incorporated within the Children's Oncology Group (COG) protocols, and only in the United States, as a risk-stratification parameter and for patient management. Therefore, the COG Liver Tumor Committee sponsored an International Pathology Symposium in March 2011 to discuss the histopathology and classification of pediatric liver tumors, and hepatoblastoma in particular, and work towards an International Pediatric Liver Tumors Consensus Classification that would be required for international collaborative projects. Twenty-two pathologists and experts in pediatric liver tumors, including those serving as central reviewers for the COG, European Socié té Internationale d'Oncologie Pé diatrique, Gesellschaft fü r Pä diatrische Onkologie und Hä matologie, and Japanese Study Group for Pediatric Liver Tumors protocols, as well as pediatric oncologists and surgeons specialized in this field, reviewed more than 50 pediatric liver tumor cases and discussed classic and newly reported entities, as well as criteria for their classification. This symposium represented the first collaborative step to develop a classification that may lead to a common treatment-stratification system incorporating tumor histopathology. A standardized, clinically meaningful classification will also be necessary to allow the integration of new biological parameters and to move towards clinical algorithms based on patient characteristics and tumor genetics, which should improve future patient management and outcome.

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Predictive Value of the Pretreatment Extent of Disease System in Hepatoblastoma: Results From the International Society of Pediatric Oncology Liver Tumor Study Group SIOPEL-1 Study

Cited by 194 publications

References 17 publications

The genetic and epigenetic landscapes of hepatoblastomas

The genetic and epigenetic landscapes of hepatoblastomas

Liver Tumors in Children

Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium

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