Predictive value of the preoperative neutrophil-to-lymphocyte ratio for the development of hepatocellular carcinoma in HBV-associated cirrhotic patients after splenectomy

Du, Zhaoqing; Dong, Jian; Bi, Jianbin; Bai, Ruhai; Jia, Zhang; Wu, Zheng; Lv, Yi; Zhang, Xufeng; Wu, Rongqian

doi:10.1371/journal.pone.0195336

Cited by 18 publications

(20 citation statements)

References 34 publications

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“…The mechanism by which the hematologic ratios in this study can be used to monitor the stages of HCC is unclear. Du et al [28] followed 230 patients with cirrhosis and found that preoperative NLR elevation was associated with an increased risk of progression to HCC in patients with cirrhosis. Jin et al [29] evaluated the prognostic value of NLR in 556 patients with HCC in BCLC stage A, and found that increased NLR was a poor prognostic indicator.…”

Section: Discussionmentioning

confidence: 99%

The value of neutrophil to lymphocyte ratio and gamma-glutamyl transpeptidase to platelet ratio in patients with hepatocellular carcinoma

Chen

Huang

et al. 2019

Medicine

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Our study aimed to evaluate the value of neutrophil to lymphocyte ratio (NLR) and gamma-glutamyl transpeptidase to platelet ratio (GPR) in patients with hepatocellular carcinoma (HCC).A total of 565 patients with pathological diagnosis of HCC were retrospectively analyzed and 414 patients diagnosed with cirrhosis were treated as a control group. All clinical materials were collected from the First Affiliated Hospital of Guangxi Medical University.The preintervention NLR, GPR, and α-fetoprotein (AFP) were significantly higher in HCC patients than in the controls (PNLR < .000, PGPR < .000, PAFP < .000). The NLR and GPR were correlated with the Barcelona clinic liver cancer (BCLC) stages, Child-Pugh grades, and tumor size, but not with Edmondson–Steiner grades. Combined use of NLR or GPR with AFP produced larger area under the curve (AUC) (AUCNLR+AFP = 0.916; AUCNLR+AFP = 0.953) than NLR (P < .000), GPR (P < .000), or AFP (P < .000) used alone.The preintervention hematologic parameters (NLR and GPR) studied herein were associated with the BCLC stages of HCC. Combined use of NLR or GPR with AFP may improve early detection and diagnosis of HCC.

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Section: Discussionmentioning

confidence: 99%

The value of neutrophil to lymphocyte ratio and gamma-glutamyl transpeptidase to platelet ratio in patients with hepatocellular carcinoma

Chen

Huang

et al. 2019

Medicine

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“…The neutrophil‐to‐lymphocyte ratio (NLR) has been studied as a biomarker in multiple solid tumors, such as hepatocellular carcinoma, renal, breast, and metastatic melanoma . Several researchers have also investigated the NLR in ICC; however, little work has been done on the relative importance of the NLR, the platelet‐to‐lymphocyte ratio (PLR), and the systemic immune‐inflammation index (SII).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory markers in intrahepatic cholangiocarcinoma: Effects of advanced liver disease

et al. 2019

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Background To investigate the neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and systemic immune‐inflammation index (SII) as prognostic biomarkers in intrahepatic cholangiocarcinoma (ICC) with a focus on viral hepatitis and liver status. Methods In this retrospective cohort study, patients from the institutional cancer registry with ICC from 2005 to 2016 were stratified by treatment group. Baseline inflammatory markers were dichotomized at the median. Overall survival (OS) was assessed via Kaplan‐Meier curves and Cox proportional hazard models. Multiple patient, liver, and tumor factors were included in the multivariable analysis (MVA). Results About 131 patients (median age 65 years, 52% male, 76% Caucasian) had a median OS of 13.0 months. Resection/interventional oncology with/without systemic therapy had improved survival vs systemic therapy alone in Child‐Pugh A patients (P < 0.01). In Child‐Pugh B/C patients, this survival difference became nonsignificant (P = 0.22). Increased NLR and SII were associated with decreased survival (P < 0.01), while dichotomized PLR was not (P = 0.3). On MVA, increased NLR remained an independent prognostic factor (HR 1.6, P < 0.05). In Child‐Pugh class A (n = 94), low‐NLR had higher OS vs high‐NLR (25.4 vs 12.2 months, P < 0.01). In Child‐Pugh class B/C (n = 28), NLR did not have a significant effect on median OS (low‐ vs high‐NLR: 6.7 vs 2.9 months, P = 0.2). Child‐Pugh class acted as an effect modifier on MVA for NLR (P = 0.0124). Conclusions The NLR has a stronger impact as a prognostic marker in ICC over the PLR and SII. This survival effect is decreased in advanced liver disease.

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“…In addition, the variety of inflammations represent a useful prognostic marker for HCC, including fibrinogen, inflammation based index (IBI), C-reactive protein (CRP), inflammation based score (IBS), Glasgow prognostic score (GPS), and neutrophil to lymphocyte ratio (NLR) [14] . NLR is a simple marker of inflammation, it provides a good indication of the patient's overall inflammatory status, also it has been used to predict tumor recurrence in HCC patients after hepatic resection [15,16] hepatocellular carcinoma (HCC. NLR has been related with activate caspase-1, which induce to produce the interleukin-18 (IL-18) and interleukin-1β (IL-1β).…”

Section: Chronic Inflammationsmentioning

confidence: 99%

“…NLR is interested in NF-κB and MAPK for signalling pathways. Thus, NLRs share in progression of HCC [15,16] .…”

Section: Chronic Inflammationsmentioning

confidence: 99%

Current Status Regarding Tumour Progression, Surveillance, Diagnosis, Staging, and Treatment Of HCC: A Literature Review

Ahmad¹,

Suardi²,

Shukri³

et al. 2019

Journal of Gastroenterology and Hepatology Research

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Hepatocellular carcinoma (HCC) is the most common primary malignant tumour of the liver, and is globally considered to be a major causes of cancer-associated mortality. The early diagnosis of HCC improves overall survival through the application of suitable treatment options. This article presents some of the techniques for the surveillance of HCC like ultrasonography and the use of tumour biomarkers such as α-fetoprotein (AFP), DesGamma-Carboxy Prothrombin (DCP) and others. Included in the discussion will be diagnostic methods like computed tomography (CT), magnetic resonance imaging (MRI), contrast enhancement ultrasound (CEUS), and fluorodeoxyglucose positron emission tomography hybrid with computed tomography (FDG PET/CT). Current molecular pathogenesis related to HCC and the molecular steps that determine the transition from benign to malignancy are also analysed. The HCC stages which depends on the Barcelona Clinic Liver Cancer (BCLC) algorithm are also discussed. Finally, this review article discusses the present therapeutic and treatment options for HCC such as resection, transplantation, or ablation used to treat early stage cancer. Also included will be trans-arterial chemoembolization (TACE) and Sorafenib for patients with intermediate and advanced-stage cancer, respectively.

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Predictive value of the preoperative neutrophil-to-lymphocyte ratio for the development of hepatocellular carcinoma in HBV-associated cirrhotic patients after splenectomy

Cited by 18 publications

References 34 publications

The value of neutrophil to lymphocyte ratio and gamma-glutamyl transpeptidase to platelet ratio in patients with hepatocellular carcinoma

The value of neutrophil to lymphocyte ratio and gamma-glutamyl transpeptidase to platelet ratio in patients with hepatocellular carcinoma

Inflammatory markers in intrahepatic cholangiocarcinoma: Effects of advanced liver disease

Current Status Regarding Tumour Progression, Surveillance, Diagnosis, Staging, and Treatment Of HCC: A Literature Review

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