Predictive value of SUA/SCr and IL-6 in patients with non-small cell lung cancer （ NSCLC ） undergoing concurrent chemoradiotherapy

Abstract

Background and objectives: For patients with inoperable non-small cell lung cancer, concurrent chemoradiotherapy is the mainstay of treatment. At present, TMN stage is still the most commonly used clinical prediction model, but in the real world, patients with the same stage receive the same mode of treatment, their survival will be significantly different. The aim of our study was to look for predictors of patient survival in addition to TMN staging. If all kinds of predictors can be combined, the survival prediction of patients can be greatly improved and the clinical treatment and medication can be guided.Methods：The survival differences of 147 lung cancer patients receiving concurrent chemoradiotherapy were analyzed. Univariate and multivariate COX regression analysis were used to explore the relationship between blood markers before treatment and patient survival.Results: Univariate COX regression analysis showed that gender, hemoglobin, MCV, NLR, Smoking Index，IL-6 and SUA/SCr were significantly correlated with survival in patients receiving concurrent chemoradiotherapy. Multivariate COX regression analysis showed that IL-6 and SUA/SCr were prognostic factors for patients receiving radiotherapy and chemotherapy. According to receiver operating characteristic (ROC) curve analysis, the AUC of SUA/SCr and IL-6 were 0.757 and 0.770, respectively, and the optimal cutoff points of SUA/SCr and IL-6 were 3.99 and 4.79, respectively.Conclusions：Our study shows that gender, hemoglobin, MCV, NLR, Smoking Index，SUA/SCr and IL-6 are related to survival of lung cancer patients. Il-6 and SUA/SCr are effective predictors of survival in lung cancer patients.