Predictive value of serum neurofilament light chain for persistent cognitive deficits in elderly depressive patients

Linnemann, Carsten; Caviezel, Marco P.; Cramer, Lena; Melcher, Tobias; Monsch, Andreas U.; Kuhle, Jens; Leyhe, Thomas

doi:10.1016/j.jadr.2021.100095

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Linnemann 19 , confirms in his studies that depression is often associated with cognitive deficits, as it was assessed with the level of the neurofilament light chain (NfL), which is known for clinical investigations in search of a cognitive deficit biomarker, enabling to predict a consecutive diagnosis of dementia in the elderly with depressive symptoms, which was perceived in the individuals in the sample in the present study.…”

Section: Resultssupporting

confidence: 64%

Assessment of Functionality and the Relationship Between Cognition and Psychological Status in Aging

Moreira

Licoviski²,

Pinto

et al. 2022

J. Health Scie.

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Aging involves a set of multiple chronic and irreversible changes, which cause loss of the individual's overall functional capacity. Cognitive, functional impairments and depressive symptoms are common as aging occurs, thus decreasing the quality of life of these individuals. To characterize the elderly through the Core Set of the International Classification of Functionality (ICF) for the health of the elderly and to assess cognitive, functional impairment and depressive symptoms. This is a study in which the sample included 60 elderly people, who were randomly selected, who attended the UBS Bonsucesso, undergoing evaluation using the ICF questionnaire, the MEEM questionnaire (Mini Mental State Examination) and the Depression Scale Geriatric - Geriatric Depression Scale (GDS). In the Functionality data, it indicated a moderate problem with the activity and participation factors. The sample showed a high level of cognitive deficit and depressive symptoms When treating elderly patients, both psychological and physiological aspects should be considered, with the need to assess, guide and treat the psychological and functional status of the elderly. Keywords: ICF. Depression. Cognitive Dysfunction. Elderly. Resumo O envelhecimento envolve um conjunto de múltiplas alterações crônicas e irreversíveis, que ocasionam perda da capacidade funcional global do indivíduo. Comprometimentos cognitivos, funcionais e sintomas depressivos são comuns conforme acontece o envelhecimento, diminuindo assim a qualidade de vida desses indivíduos. Caracterizar idosos através de Core Set da Classificação Internacional de Funcionalidade (CIF) para saúde de idosos e avaliar o comprometimento cognitivo, funcional e sintomas depressivos. Trata-se de um estudo onde a amostra incluiu 60 idosos, que foram selecionados aleatoriamente, atendidos na UBS Bonsucesso, sendo submetidos a avaliação utilizado o questionário da CIF, o questionário MEEM (Mini Exame do Estado Mental) e a Escala de Depressão Geriátrica – Geriatric Depression Scale (GDS). Nos dados da Funcionalidade, indicou moderado problema aos fatores de atividade e participação. A amostra apresentou alto nível de déficit cognitivo e sintomas depressivos. Ao tratar de pacientes idosos, deve-se considerar tanto aspectos psicológicos quanto fisiológicos, existindo a necessidade de avaliar, orientar e tratar o estado psicológico e funcional dos idosos. Palavras-chave: CIF. Depressão. Disfunção Cognitiva. Idosos.

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Section: Resultssupporting

confidence: 64%

Assessment of Functionality and the Relationship Between Cognition and Psychological Status in Aging

Moreira

Licoviski²,

Pinto

et al. 2022

J. Health Scie.

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“…Those diagnosed with depression had significantly higher levels of CSF NfL compared with those without depression. A further study involving elderly participants reported that the mean serum NfL of participants with depression and subsequent dementia was significantly higher than in a study group of depressive participants who exhibited cognitive recovery [44 ▪ ].…”

Section: Neurofilament Light Protein In Depression and Psychiatric Di...mentioning

confidence: 77%

Neurofilament light protein as a biomarker in depression and cognitive function

Travica

Berk

Marx

2021

Current Opinion in Psychiatry

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Purpose of reviewConverging evidence suggest axonal damage is implicated in depression and cognitive function. Neurofilament light protein, measured within serum and cerebrospinal fluid, may be a biomarker of axonal damage. This article examines the emerging evidence implicating neurofilament light protein in depression and cognitive function. Recent findingsPreliminary cross-sectional and case-control studies in cohorts with depression have yielded inconsistent results regarding the association between neurofilament light protein and symptomatology. However, these studies had methodological limitations, requiring further investigation. Importantly, neurofilament light protein concentrations may be a marker of progression of cognitive decline and may be associated with cognitive performance within cognitively intact cohorts.

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Serum neurofilament light chain, markers of systemic inflammation and clinically relevant depressive symptoms in US adults

Guo,

Zhu

2024

Journal of Affective Disorders

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Predictive value of serum neurofilament light chain for persistent cognitive deficits in elderly depressive patients

Cited by 3 publications

References 18 publications

Assessment of Functionality and the Relationship Between Cognition and Psychological Status in Aging

Assessment of Functionality and the Relationship Between Cognition and Psychological Status in Aging

Neurofilament light protein as a biomarker in depression and cognitive function

Serum neurofilament light chain, markers of systemic inflammation and clinically relevant depressive symptoms in US adults

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