Predictive Value of Selected Biomarkers, Polymorphisms, and Clinical Features for Oligoarticular Juvenile Idiopathic Arthritis-associated Uveitis

Pelegrín, Laura; Casaroli‐Marano, Ricardo P.; Antón, Jordi; Vicuña, María Carmen García de; Molina-Prat, Nicolás; Aróstegui, Juan I.; Yagüe, Jordi; Ríos, José; Adán, Alfredo

doi:10.3109/09273948.2013.841495

Cited by 23 publications

(14 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Apart from demographic and clinical data, further biomarkers to predict uveitis risk for an individual patient are highly desirable. Interestingly, ESR has been shown to correlate well with the risk for uveitis . In our study, an ESR >35 mm/hour at first documentation was associated with a significantly higher risk for uveitis onset during followup (OR 2.0, P < 0.001; univariate analysis) (Table ).…”

Section: Discussionmentioning

confidence: 50%

Impact of Antiinflammatory Treatment on the Onset of Uveitis in Juvenile Idiopathic Arthritis: Longitudinal Analysis From a Nationwide Pediatric Rheumatology Database

Tappeiner

Schenck

Niewerth

et al. 2015

Arthritis Care & Research

View full text Add to dashboard Cite

ObjectiveBased on a nationwide database, this study analyzed the influence of methotrexate (MTX), tumor necrosis factor (TNF) inhibitors, and a combination of the 2 medications on uveitis occurrence in juvenile idiopathic arthritis (JIA) patients.MethodsData from the National Paediatric Rheumatological Database in Germany were used in this study. Between 2002 and 2013, data from JIA patients were annually documented at the participating pediatric rheumatologic sites. Patients with a JIA disease duration of <12 months at initial documentation and ≥2 years of followup were included in this study. The impact of antiinflammatory treatment on the occurrence of uveitis was evaluated by discrete‐time survival analysis.ResultsA total of 3,512 JIA patients (mean ± SD age 8.3 ± 4.8 years, 65.7% female, 53.2% antinuclear antibody positive, and mean ± SD age at arthritis onset 7.8 ± 4.8 years) fulfilled the inclusion criteria. Mean ± SD total followup time was 3.6 ± 2.4 years. Uveitis developed in a total of 180 patients (5.1%) within 1 year after arthritis onset. Uveitis onset after the first year was observed in another 251 patients (7.1%). Disease‐modifying antirheumatic drug (DMARD) treatment in the year before uveitis onset significantly reduced the risk for uveitis as follows: MTX: hazard ratio (HR) 0.63, P = 0.022; TNF inhibitors: HR 0.56, P < 0.001; and a combination of the 2 medications: HR 0.10, P < 0.001. Patients treated with MTX within the first year of JIA had an even a lower uveitis risk (HR 0.29, P < 0.001).ConclusionThe use of DMARDs in JIA patients significantly reduced the risk for uveitis onset. Early MTX use within the first year of disease and the combination of MTX with a TNF inhibitor had the highest protective effect.

show abstract

Section: Discussionmentioning

confidence: 50%

Impact of Antiinflammatory Treatment on the Onset of Uveitis in Juvenile Idiopathic Arthritis: Longitudinal Analysis From a Nationwide Pediatric Rheumatology Database

Tappeiner

Schenck

Niewerth

et al. 2015

Arthritis Care & Research

View full text Add to dashboard Cite

show abstract

“…Four previous studies examined the relationship between ESR and the occurrence of uveitis in patients with JIA. 4,10,17,18 Elevated ESR appeared to be predictive in 3 of these previous retrospective studies as well. Statistically, these studies found significantly more elevated ESR values of > _35 mm in patients with uveitis…”

Section: Discussionmentioning

confidence: 68%

“…This is the second study demonstrating an elevated ESR to be predictive after adjusting for other predictors in a larger study population. 18 One study described ESR as not having a significant influence on the occurrence of uveitis according to multivariate analysis. 4 Patients diagnosed with uveitis prior to the onset of JIA were not excluded from this study, which might explain this contrasting outcome.…”

mentioning

confidence: 99%

Erythrocyte Sedimentation Rate as Baseline Predictor for the Development of Uveitis in Children With Juvenile Idiopathic Arthritis

Haasnoot

Tent-Hoeve

Wulffraat

et al. 2015

American Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Furthermore, our study gave new insight into the role of clinical activity scores and biomarkers (e.g., ESR and S100A12) as prognostic markers for uveitis in JIA. In 4 previous studies, elevated ESR predicted uveitis manifestations , while this was only true for the ERA subgroup of JIA in another study from a German cohort . It may be speculated that a high ESR correlates with the activity of autoimmune processes in JIA, potentially under the influence of Treg cells .…”

Section: Discussionmentioning

confidence: 83%

“…An elevated erythrocyte sedimentation rate (ESR) may indicate activity of an autoimmune disease. Indeed, previous studies indicated an elevated risk of uveitis in JIA patients with an elevated ESR , while no such correlation was found in others . For other factors (e.g., C‐reactive protein [CRP]), no correlation with uveitis risk in JIA has been found previously .…”

mentioning

confidence: 95%

Risk Factors and Biomarkers for the Occurrence of Uveitis in Juvenile Idiopathic Arthritis

Tappeiner

Klotsche

Sengler

et al. 2018

Arthritis & Rheumatology

View full text Add to dashboard Cite

ObjectiveTo analyze the prognostic value of demographic, clinical, and therapeutic factors and laboratory biomarkers and to assess their role in predicting uveitis occurrence in patients with juvenile idiopathic arthritis (JIA).MethodsPatients with JIA were enrolled within the first year after JIA diagnosis. Demographic and clinical parameters were documented. Serum samples were collected at study enrollment, at 3‐month follow‐up visits within the first year, and then every 6 months. A multivariable Cox regression analysis was performed to evaluate the impact of demographic, clinical, laboratory, and therapeutic parameters on uveitis onset.ResultsWe included 954 JIA patients (67.2% female, 54.2% antinuclear antibody [ANA] positive, mean ± SD age at onset 7.1 ± 4.6 years). Uveitis occurred in 133 patients (observation period 44.5 months). Young age at JIA onset and ANA positivity were significantly associated with the onset of uveitis (both P < 0.001). Treatment of arthritis with methotrexate alone (hazard ratio [HR] 0.18 [95% confidence interval (95% CI) 0.12–0.29], P < 0.001) or combined with etanercept (HR 0.10 [95% CI 0.04–0.23], P < 0.001) or adalimumab (HR 0.09 [95% CI 0.01–0.61], P = 0.014) reduced the risk of uveitis onset and the occurrence of uveitis‐related complications. Predictors of uveitis onset included elevated erythrocyte sedimentation rate at baseline (HR 2.36 [95% CI 1.38–4.02], P = 0.002) and continuing moderate or high disease activity during follow‐up as measured by the 10‐joint clinical Juvenile Arthritis Disease Activity Score (HR 4.30 [95% CI 2.51–7.37], P < 0.001). Additionally, S100A12 levels ≥250 ng/ml at baseline were significantly associated with the risk of uveitis (HR 2.10 [95% CI 1.15–3.85], P = 0.016).ConclusionApart from demographic risk factors and treatment modalities, JIA disease activity scores and laboratory biomarkers could be used to better define the group of JIA patients at high risk of uveitis onset.

show abstract

Predictive Value of Selected Biomarkers, Polymorphisms, and Clinical Features for Oligoarticular Juvenile Idiopathic Arthritis-associated Uveitis

Abstract: An age-associated risk of uveitis was observed in children younger than 3 years at the time of JIA onset. ESR values at arthritis onset higher than 22 mm/h were also related to uveitis development.

Cited by 23 publications

References 21 publications

Impact of Antiinflammatory Treatment on the Onset of Uveitis in Juvenile Idiopathic Arthritis: Longitudinal Analysis From a Nationwide Pediatric Rheumatology Database

Impact of Antiinflammatory Treatment on the Onset of Uveitis in Juvenile Idiopathic Arthritis: Longitudinal Analysis From a Nationwide Pediatric Rheumatology Database

Erythrocyte Sedimentation Rate as Baseline Predictor for the Development of Uveitis in Children With Juvenile Idiopathic Arthritis

Risk Factors and Biomarkers for the Occurrence of Uveitis in Juvenile Idiopathic Arthritis

Contact Info

Product

Resources

About