Predictive value of respiratory syncytial virus-specific IgE responses for recurrent wheezing following bronchiolitis

Welliver, Robert C.; Sun, Martha; Rinaldo, D.; Ogra, Pearay L.

doi:10.1016/s0022-3476(86)80692-8

Cited by 208 publications

(92 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The production of antiviral IgE, along with neutralizing IgG antibodies, provides a further link between these disparate responses ( 6 -10 ). In fact, IgE serum concentrations have been correlated with subsequent wheezing in infants with respiratory viral infection and with the risk of otitis media with eff usion in children ( 10,11 ). How a Th1-biased response generates a Th2 phenotype is not known, although we now show that the high-affi nity receptor for IgE on DCs bridges the antiviral Th1 response to the atopic/proasthmatic Th2 response.…”

mentioning

confidence: 74%

Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia

Grayson¹,

Cheung²,

Rohlfing³

et al. 2007

J Cell Biol

106

View full text Add to dashboard Cite

mentioning

confidence: 74%

Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia

Grayson¹,

Cheung²,

Rohlfing³

et al. 2007

J Cell Biol

106

View full text Add to dashboard Cite

“…Similar study by Welliver et al had 72 infants with RSV bronchiolitis more than 25 subjects showed raised IgE levels. 11 And among them 17 had wheeze on follow up. In present study, among the raised IgE levels 37 subjects, 45% (17 subjects) of them acquired wheeze.…”

Section: Ige Levels In Bronchiolitismentioning

confidence: 99%

Prevalence of raised IgE levels and absolute eosinophil count in bronchiolitis in children aged 2 months-2 years in tertiary care hospital

2016

View full text Add to dashboard Cite

INTRODUCTIONBronchiolitis is defined by IAP as ' A constellation of clinical symptoms and signs including viral upper respiratory prodrome followed by increased respiratory effort and wheeze in less than 2 year old children'. Many virus cause bronchiolitis with Respiratory syncytial virus being common. Epidemiology of RSV has many unusual characteristics. They infect children nearly in first year of life with the peak incidence in 2-8 months. It is the only virus which cause most severe respiratory disease in the first month of life when there is antibodies from the mother.1 WHO estimated RSV burden globally as 64 million cases and 1,50,000 deaths every year. Peak incidences are at 2-8 months of age. This is one of the common causes of hospitalisation Intensive care is needed for about 15% to 30% of RSV infections. Due to respiratory failure, apnoea 7% to 21% of hospitalised patient needs mechanical ventilation.2 Some prospective study have suggested that RSV infection predisposes to blood eosinophilia and airway ABSTRACT Background: Bronchiolitis is defined by IAP as 'A constellation of clinical symptoms and signs including viral upper respiratory prodrome followed by increased respiratory effort and wheeze in less than 2 year old children'. Aim of the study was to study the prevalence of raised IgE levels and raised Absolute eosinophil count & RSV (respiratory syncytial virus) antigen by PCR in bronchiolitis between age group of 2 months -2 years with the occurrence of wheeze after first episode in 1 year follow up. Methods: 96 Children between 2 months -2 years with first episode of bronchiolitis are included with the exclusion criteria of previous heart disease, lung disease, immune deficiency, second episode of bronchiolitis. In all the children CRP (C reactive protein), IgE (Immunoglobulin E), AEC (Absolute eosinophil count), RSV, PCR was done. Results: Out of 96 children, 60 children (62%) are males with maximum incidence on subjects of 53 (55.2%) in age group 2-6months. Fever, cough and rhinorrhoea are the major presenting complaints apart from breathlessness. Among 96 children 37 children (38.5%) had high serum IgE out of which 17 developed wheeze in 1 year of follow up. 27 (28.2%) had raised AEC, out of which 10 had wheeze in follow up. Out of 10 children who had raised IgE and AEC, 3 had wheeze on follow up. 34 (35.4%) children had positive RSV PCR, 14 children had wheeze in follow up. Conclusions: The prevalence of raised IgE, AEC and RSV PCR are 38.5%, 28.1% and 41.1% and the occurrence of wheeze on follow up was 45.9%, 37% and 41.1% respectively.

show abstract

“…Murray et al (1992) destacaram o fumo materno como fator de risco para sibilância pós-bronquiolite. Welliver et al (1986b) encontraram associação significativa entre sibilância recorrente e exposição ao fumo passivo, não especificamente o materno, ainda que outros autores não tenham evidenciado tal relação (Welliver et al, 1986a;Sigurs et al, 1995).…”

Section: Variávelunclassified

“…Embora a literatura mostre que meninos sibilam mais do que as meninas (Pullan & Hey, 1982;Welliver et al, 1986a), tal associação não foi aqui demonstrada. Panitch et al (1993) apontaram história familiar de asma e de atopia como fatores de risco para sibilância recorrente pós-bronquiolite.…”

Section: Variávelunclassified

“…Vários estudos sugerem que crianças hospitalizadas por bronquiolite têm risco aumentado de apresentar seqüela pulmonar (Kattan et al, 1977;Sims et al, 1981;McConnochie & Roghmann, 1985;Milner & Murray, 1989), caracterizada principalmente por tosse e sibilância recorrente (McConnochie & Roghmann, 1984;Welliver et al, 1986a;Murray et al, 1992;Panitch et al, 1993;Kuikka et al, 1994;Sigurs et al, 1995). Permanece controverso se a infecção causaria dano ao pulmão em crescimento ou se haveria alterações prévias da via aérea, tornando algumas crianças mais suscetíveis a desenvolverem a infecção (Martinez et al, 1988;Everard & Milner, 1992;Young et al, 1995).…”

Section: Introductionunclassified

See 1 more Smart Citation

Hospitalização por bronquiolite aguda como fator de risco para sibilância recorrente

et al. 2000

View full text Add to dashboard Cite

Predictive value of respiratory syncytial virus-specific IgE responses for recurrent wheezing following bronchiolitis

Cited by 208 publications

References 14 publications

Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia

Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia

Prevalence of raised IgE levels and absolute eosinophil count in bronchiolitis in children aged 2 months-2 years in tertiary care hospital

Hospitalização por bronquiolite aguda como fator de risco para sibilância recorrente

Contact Info

Product

Resources

About