Predictive value of red cell distribution width in intrahospital mortality and postintervention thrombolysis in myocardial infarction flow in patients with acute anterior myocardial infarction

Erkan, I.; Güvenç, Tolga Sinan; Altay, Servet; Çağdaş, Metin; Çalık, Ali Nazmi; Karaca, Mehmet; Güzelburç, Özge; Karaca, Gurkan; Biteker, Murat; Tayyareci, Gülşah

doi:10.1097/mca.0b013e3283587897

Cited by 19 publications

(14 citation statements)

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“…Six of the studies had a prospective study design, while the rest were retrospective in nature. Study duration varied from 1 month to 4 years, with one study (Ilhan et al [ 23 ]) notably limited to in-hospital (prior to discharge) mortality outcome. The study populations were composed of varying permutations of ACS phenotypes (ST elevation myocardial infarction or STEMI, non-ST elevation myocardial infarction or NSTEMI, and unstable angina or UA).…”

Section: Resultsmentioning

confidence: 99%

Red Cell Distribution Width and Mortality in Patients With Acute Coronary Syndrome: A Meta-Analysis on Prognosis

et al. 2018

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BackgroundRed cell distribution width (RDW), a routine component of the complete blood count (CBC), measures variation in the size of circulating erythrocytes. It has been associated with several clinical outcomes in cardiovascular disease. We sought to strengthen the association between RDW and mortality in patients admitted for acute coronary syndrome (ACS) by pooling together data from available studies.MethodsStudies that fulfilled the following were identified for analysis: 1) observational; 2) included patients admitted for ACS; 3) reported data on all-cause or cardiovascular (CV) mortality in association with a low or high RDW; and 4) used logistic regression analysis to control for confounders. Using MEDLINE, Clinical Key, ScienceDirect, Scopus, and Cochrane Central Register of Controlled Trials databases, a search for eligible studies was conducted until January 9, 2017. The quality of each study was evaluated using the Newcastle-Ottawa Quality Assessment Scale. Our primary outcome of interest was all-cause or CV mortality. We also investigated the impact of RDW on major adverse cardiovascular events (MACEs) for the studies that reported these outcomes. Review Manager (RevMan) 5.3 was utilized to perform Mantel-Haenzel analysis of random effects and compute for relative risk.ResultsWe identified 13 trials involving 10,410 patients, showing that in ACS, a low RDW is associated with a statistically significant lower all-cause or CV mortality (RR 0.35, (95% CI 0.30 to 0.40), P < 0.00001, I2 = 53%), a finding that was consistent both in the short- and long-term.ConclusionsA low RDW is also associated with lower risk for MACEs after an ACS (RR 0.56, (95% CI 0.51 to 0.61), P < 0.00001, I2 = 91%). A low RDW during an ACS is associated with lower all-cause or CV mortality and lower risk of subsequent MACEs, providing us with a convenient and inexpensive risk stratification tool in ACS patients.

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Section: Resultsmentioning

confidence: 99%

Red Cell Distribution Width and Mortality in Patients With Acute Coronary Syndrome: A Meta-Analysis on Prognosis

et al. 2018

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“…Red blood cell distribution width (RDW), which is a readily available parameter in complete blood cell counts (CBC), has been conventionally used for the evaluation of heterogeneity of circulating erythrocytes and differential diagnosis of anemia . However, recent studies have found that increased RDW also shows promising predictive value for many diseases with high mortality, such as hypertension, myocardial infarction, coronary heart disease, heart failure, sepsis, and acute pancreatitis . Although the underlying biological and metabolic mechanism of increased RDW has not been validated, the association between higher RDW and higher mortality risk in many diseases indicates that the clinical significance of RDW should be broadened.…”

Section: Introductionmentioning

confidence: 99%

Red Cell Distribution Width as an Independent Predictor of Long-Term Mortality in Hip Fracture Patients: A Prospective Cohort Study

Zhang

Long

et al. 2015

Journal of Bone and Mineral Research

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Red blood cell distribution width (RDW) has been found to be a significant prognostic factor of mortality in many cardiovascular diseases. However, a link between RDW at admission with long-term mortality in the hip fracture population has not been well established. Therefore, we sought to evaluate the long-term prognostic value of RDW in a well-defined hip fracture cohort, and to compare the effect of RDW in patients with and without anemia. A prospective cohort study was performed on 1479 hip fracture patients admitted at the General Hospital of Chinese PLA between January 2000 and October 2011 with a follow-up study over a 2-year period. A total of 1479 patients were used for the evaluation of 2-year all-cause mortality, while 804 patients with more than 4 years of follow-up were extracted for further evaluation of 4-year all-cause mortality. Cox proportional regression was used to evaluate the association between admission RDW and long-term mortality, adjusting for potential confounding variables. Higher RDW values were strongly associated with increased all-cause mortality. After adjusting for age, mean corpuscular volume, admission hemoglobin, comorbidities, and complications, RDW had a significant independent association with both 2-year mortality with a hazard ratio (HR) of 1.183 (95% confidence interval [CI], 1.017 to 1.376) and 4-year mortality with an HR of 1.244 (95% CI, 1.052 to 1.471). In stratified analysis, the effect of RDW was even more pronounced, with 2-year mortality HR of 1.341 (95% CI, 1.095 to 1.643) and 4-year mortality HR of 1.345 (95% CI, 1.071 to 1.688) in non-anemic patients. In non-anemic patients, elevated RDW values are significantly associated with increased odds of all-cause mortality, implying that RDW may be a possible laboratory biomarker for risk stratification in non-anemic hip fracture patients. Further studies are needed to confirm the current finding in different and larger hip fracture cohorts.

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“…As demonstrated in previous studies, the RDW is correlated with CHD, peripheral atherosclerosis 3) and diabetes 4) , and the RDW values are markedly higher in acute myocardial infarction (AMI) patients than in those without a history of myocardial infarction (MI) 5) . In addition, the RDW values are correlated with the in-hospital mortality of AMI patients undergoing direct PCI 6) , AMI patients with a significantly elevated pre-discharge RDW compared to that observed on admission tend to have a higher mortality rate and worse prognosis 7) . The above results indicate that the RDW is correlated with the occurrence and prognosis of AMI.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the Red Blood Cell Distribution Width and Risk of Acute Myocardial Infarction

Wang¹,

Wang²,

Li³

et al. 2015

JAT

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Aims: Recently, a number of studies have shown an increased red blood cell distribution width (RDW) to be a strong and independent predictor of the prognosis of coronary artery disease. The aim of this study was to investigate the underlying mechanisms responsible for the relationship between the RDW and a poor prognosis of coronary artery disease. Methods: Four hundred and twenty-four patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention (pPCI) were analyzed retrospectively. We evaluated the relationships between the RDW and the high-sensitivity C-reactive protein (hsCRP) N-terminal pro-brain natriuretic peptide (NTpro-BNP), fasting blood glucose and lipid levels, as well as other parameters of blood examinations and angiographic manifestations. Results: There were 85 patients in the RDW ≥ 14% group (mean age 60.62 11.29 years, and men: 87%) and 339 patients in the RDW 14% group (mean age: 59.74 11.55 years, and men: 78%). The RDW ≥ 14% group had higher platelet distribution width (PDW), NTpro-BNP and hsCRP values on admission, a heavier intracoronary thrombotic burden and a higher incidence of threebranch vascular lesions than the RDW 14% group. In the multiple logistic regression analysis, the associations between the RDW and the NTpro-BNP level, incidence of three-branch and left main lesions and intracoronary thrombotic burden remained. Conclusions: A high RDW may be associated with the severity and instability of acute myocardial infarction.J Atheroscler Thromb, 2015; 22:21-26.

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Predictive value of red cell distribution width in intrahospital mortality and postintervention thrombolysis in myocardial infarction flow in patients with acute anterior myocardial infarction

Abstract: A high admission RDW level in patients with acute AMI undergoing a primary percutaneous coronary intervention was associated with an increased risk for intrahospital cardiovascular mortality, but was not associated with worse postinterventional TIMI flow.

Cited by 19 publications

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Red Cell Distribution Width and Mortality in Patients With Acute Coronary Syndrome: A Meta-Analysis on Prognosis

Red Cell Distribution Width and Mortality in Patients With Acute Coronary Syndrome: A Meta-Analysis on Prognosis

Red Cell Distribution Width as an Independent Predictor of Long-Term Mortality in Hip Fracture Patients: A Prospective Cohort Study

Relationship between the Red Blood Cell Distribution Width and Risk of Acute Myocardial Infarction

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