Predictive value of rapid virological response and early virological response on sustained virological response in HCV patients treated with pegylated interferon α‐2a and ribavirin

Abstract

The RVR and EVR rates of patients with genotype 1 were significantly lower than those of patients with genotype 2 or 3. RVR had a similar predictive value as EVR on SVR. Genotype, HCV RNA level, RVR and EVR were associated with SVR. Genotype, RVR and EVR were independent factors for predicting the effect of antiviral therapy.

Sustained virological response based on rapid virological response in genotype-3 chronic hepatitis C treated with standard interferon in the Pakistani population

“…A recent study by Yu et al [20] with PgIF reported RVR and SVR at 86% and 94% respectively. Another recent study by Yu et al reported RVR with PgIF in genotype-3 at 60% [17] . Cost effectiveness of the RVR based therapy with PgIF is established by recent reports not only in HCV infection alone but also in combined HCV/HIV infections [7,8] .…”

“…In Pakistan the most common genotype is 3 which is highly responsive to SdIF [5,16] . RVR is now a new landmark in the treatment and retreatment of HCV and it not only determines the duration but also predicts the outcome of the therapy [17][18][19] . For genotype-2 most of the studies are in favour of a 16 wk therapy in patients who achieve RVR but there is no such recommendation for genotype-3 [9] .…”

10.5937/mckg48-5925 = Therapy of chronic HCV infection: Association between virological response and predictive factors

“…Bolesnici koji su inficirani HCV genotipom 1 i postignu rani virusološki odgovor (HCV rnK pozitivna u 4. nedelji, ali negativna 12. nedelji terapije) leče se 48 nedelja. Odsustvo HCV rnK nakon 48 nedelja lečenja definiše se kao odgovor na kraju terapije (End Tretatmen response -ETr) (28)(29)(30)(31)(32)(33)(34)(35). Trajni virusološki odgovor (Sustained Viral responseSVr) definiše se odsutnošću virusa u krvi (HCV rnK <50 iu/ml), šest meseci nakon završetka terapije.…”

“…drugi prediktori uključuju bazalni nivo HCV rnK, body-mass indeks domaćina, starost, insulinsku rezistenciju, nivo aminotransferaza, koinfekciju sa HBV ili HiV virusom, steatozu jetre, zloupotrebu alkohola (24,(28)(29)(30)(31)(32)(33)(34)(35).…”

“…Pokazano je da se SVr javlja kod oko 50% lečenih koji su inficirani genotipom 1 i kod oko 80% u slučaju infekcije genotipom 2 i 3 (28,(30)(31). Takođe, brzi pad viremije na početku terapije pokazao se kao dobar prognostički pokazatelj uspeha lečenja, što je često presudno u odluci o nastavljanju ili prekidu lečenja (35). S druge strane, jedan od najznačajnih prognostičkih faktora domaćina jeste stadijum fibroze koji, iako ima prognostički značaj, ipak predstavlja samo indirektni pokazatelj imunopatogenetskih mehanizama koji imaju ključnu ulogu u rešavanju infekcije ili njenom daljem perzistiranju (36).…”