Predictive value of progression-associated chromosomal aberrations for the prognosis of meningiomas: a retrospective study of 198 cases

Ketter, Ralf; Henn, Wolfram; Niedermayer, Isolde; Steilen-Gimbel, Heike; König, Jochem; Zang, K. D.; Steudel, Wolf-Ingo

doi:10.3171/jns.2001.95.4.0601

Cited by 103 publications

(93 citation statements)

References 44 publications

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“…Some authors reported that meningiomas with chromosome 1p loss show the higher rate of recurrence occurring independently from the histological classification. [7][8][9] In our series, some lowgrade meningiomas had FISH 1p definitive deletion and 19q monosomy or polysomy. Further investigation is needed to determine whether these low-grade meningiomas with chromosomal abnormality have high rates of recurrence and progression.…”

Section: Discussionsupporting

confidence: 44%

Fluorescent In Situ Hybridization 1p/19q Deletion/Imbalance Analysis of Low-Grade and Atypical Meningiomas

Nagasaka

Gunji

Hosokai

et al. 2010

Neurol. Med. Chir.(Tokyo)

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The chromosomal 1p/19q state was analyzed in 16 low-grade meningiomas and 7 atypical meningiomas using fluorescent in situ hybridization (FISH) analysis. Chromosome 1p aberrations were observed in all atypical meningiomas, but in only one low-grade meningioma. Atypical meningiomas showed 19q deletion or imbalance, suggesting chromosomal instability of 19q. A small group of low-grade meningioma showed 19q aberrations. FISH 1p/19q deletion/imbalance analysis is a sensitive method for detecting chromosome aberrations of meningiomas and provides useful information for grading of meningiomas. Patients with low-grade meningioma with chromosomal instability of 1p/19q should be followed up carefully. Assessment of the chromosomal state by FISH might be of crucial importance in the clinical management of meningiomas.

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Section: Discussionsupporting

confidence: 44%

Fluorescent In Situ Hybridization 1p/19q Deletion/Imbalance Analysis of Low-Grade and Atypical Meningiomas

Nagasaka

Gunji

Hosokai

et al. 2010

Neurol. Med. Chir.(Tokyo)

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“…In a previous study, we classified 198 consecutive meningiomas into four groups according to their karyotypes [4]. We found a very strong correlation between the cytogenetic findings and the rates of tumor recurrence.…”

Section: Discussionmentioning

confidence: 74%

“…Cytogenetic aberrations of meningiomas have later been shown to be significantly associated with the tumor location as well. Nearly half of the meningiomas of the cranial vault display progression-associated chromosome aberrations [4]. In 1980, Zankl and Zang showed that meningiomas of the skull base typically present with 46 chromosomes, whereas those of the convexity have significantly more chromosome aberrations [29].…”

Section: Discussionmentioning

confidence: 99%

“…Although meningiomas are usually benign WHO grade I tumors, about 10% of meningiomas are more aggressive (grades II or III) and tend to recur [1]. The most common primary cytogenetic feature of all grades of meningioma is monosomy 22, whereas tumor progression and recurrence is associated with stronger hypodiploidy, in particular monosomy of chromosomes 14 and/or 18, and loss of the short arm of a chromosome 1 [2][3][4][5][6]. Hyperdiploidy, on the other hand, has long been known to be found in rare instances of meningiomas [2,7,8].…”

Section: Introductionmentioning

confidence: 99%

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Hyperdiploidy defines a distinct cytogenetic entity of meningiomas

et al. 2007

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Background The most common chromosomal aberration found in meningiomas is monosomy 22. Progression and recurrence of meningiomas are usually associated with additional chromosome losses. Rarely, however, meningiomas have strongly hyperdiploid karyotypes with over 50 chromosomes; the objective of this study was to explore the cytogenetic and histopathologic patterns as well as the clinical significance of hyperdiploidy in meningiomas. Methods Within a series of 677 consecutive meningiomas, we identified a subgroup comprising 16 cases that display a strikingly uniform pattern of hyperdiploidy mostly without structural chromosome rearrangements, as shown by banding techniques and, in the single structurally aberrant case, spectral karyotyping. Results These meningiomas each have between 50 and 56 chromosomes, with trisomy 12 (14/16 cases), trisomy 20 (13/16 cases), trisomy 5 (12/16 cases), and trisomy 17 (10/16 cases). Histomorphologically, hyperdiploid meningiomas feature a heterogeneous phenotype. However, they are associated with a higher histological grade, and decreased expression of alkaline phosphatase as compared to meningiomas with typical karyotype. In two patients, recurrences were documented and three patients died of disease during the period of observation, indicating a worse prognosis of hyperdiploid than of cytogenetically typical meningiomas. Conclusion We conclude that hyperdiploidy constitutes a small but clinically relevant entity of biologically aggressive meningiomas, which are cytogenetically distinguishable from the majority of commontype meningiomas.

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“…Interestingly, Ketter, et al, 11 stated that all spinal meningiomas in their series (23 of 198) had a normal chromosomal set or a monosomy of 22. This genotype was not associated with disease recurrence, in contrast to intracranial meningiomas, which had a higher rate of tumors with multiple chromosomal aberrations, correlating with higher rates of recurrences.…”

Section: Genetic Alterationsmentioning

confidence: 94%

Spinal meningiomas: surgical management and outcome

Gottfried

Gluf

Quiñones‐Hinojosa

et al. 2003

FOC

183

163

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Advances in imaging and surgical technique have improved the treatment of spinal meningiomas; these include magnetic resonance imaging, intraoperative ultrasonography, neuromonitoring, the operative microscope, and ultrasonic cavitation aspirators. This study is a retrospective review of all patients treated at a single institution and with a pathologically confirmed diagnosis of spinal meningioma. Additionally the authors analyze data obtained in 556 patients reported in six large series in the literature, evaluating surgical techniques, results, and functional outcomes. Overall, surgical treatment of spinal meningiomas is associated with favorable outcomes. Spinal meningiomas can be completely resected, are associated with postoperative functional improvement, and the rate of recurrence is low.

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Predictive value of progression-associated chromosomal aberrations for the prognosis of meningiomas: a retrospective study of 198 cases

Abstract: The cytogenetic classification of meningiomas provides a significant contribution to the predictability of tumor recurrence and is, therefore, a valuable criterion for the neurosurgeon's postoperative management protocol.

Cited by 103 publications

References 44 publications

Fluorescent In Situ Hybridization 1p/19q Deletion/Imbalance Analysis of Low-Grade and Atypical Meningiomas

Fluorescent In Situ Hybridization 1p/19q Deletion/Imbalance Analysis of Low-Grade and Atypical Meningiomas

Hyperdiploidy defines a distinct cytogenetic entity of meningiomas

Spinal meningiomas: surgical management and outcome

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