Predictive value of plasma miRNA-718 for esophageal squamous cell carcinoma

Sun, Li; Dong, Shuling; Dong, Cuicui; Sun, Kang; Meng, Weiwei; Lv, Pin; Yin, Hang; Ming, Liang; He, Fucheng

doi:10.3233/cbm-150564

Cited by 21 publications

(12 citation statements)

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“…Moreover, upregulated miR-21 was detected in saliva supernatants with the AUC of 0.698 [48] and exosomes [49]. Not only miR-21, but also miR-23a [50], miR-506 [51], miR-718 [52] and miR-216a/b [53] were found as circulating biomarkers for diagnosis of ESCC. A meta-analysis [54] including 27 studies reported that circulating miRNAs with a combined AUC of 0.87 could be used as a biomarkers for early diagnosis of ESCC.…”

Section: Discussionmentioning

confidence: 99%

Identification of molecular targets for esophageal carcinoma diagnosis using miRNA-seq and RNA-seq data from The Cancer Genome Atlas: a study of 187 cases

et al. 2017

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Esophageal carcinoma (ESCA) is one of the most common malignancies worldwide, and its pathogenesis is complex. In this study, we identified differentially expressed miRNAs (DEMs) and genes (DEGs) of ESCA from The Cancer Genome Atlas (TCGA) database. The diagnostic values of DEMs were determined by receiver operating characteristic (ROC) analyses and validated based on data from Gene Expression Omnibus (GEO). The top five DEMs with the best diagnostic values were selected, and their potential targets were predicted by various in silico methods. These target genes were then identified among the DEGs from TCGA. Furthermore, the overlapping genes were subjected to protein-protein interaction (PPI) analysis, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. The miRNA-transcription factor (TF) regulatory relations were determined using CircuitsDB and TransmiR. Finally, the regulatory networks of miRNA-TF and miRNA-gene were constructed and analyzed. A total of 136 DEMs and 3541 DEGs were identified in ESCA. The top five DEMs with the highest area under the receiver operating characteristic curve (AUC) values were miRNA-93 (0.953), miRNA-21 (0.928), miRNA-4746 (0.915), miRNA-196a-1 (0.906) and miRNA-196a-2 (0.906). The combined AUC of these five DEMs was 0.985. The KEGG analysis with 349 overlapping genes showed that the calcium signaling pathway and the neuroactive ligand-receptor interaction were the most relevant pathways. The regulatory networks of miRNA-TF and miRNA-gene, including 38 miRNA-TF and 560 miRNA-gene pairs, were successfully established. Our findings may provide new insights into the molecular mechanisms of ESCA pathogenesis. Future research will aim to explore the role of novel miRNAs in the pathogenesis and improve the early diagnosis of ESCA.

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Section: Discussionmentioning

confidence: 99%

Identification of molecular targets for esophageal carcinoma diagnosis using miRNA-seq and RNA-seq data from The Cancer Genome Atlas: a study of 187 cases

et al. 2017

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“…Increasing evidence demonstrates that circulating miRNAs could serve as reliable biomarkers for the detection of various cancers. A research by Sun, Dong et al () has shown that the plasma miRNA‐718 expression level of patients with ESCC is significantly lower than that of healthy controls and that the plasma miRNA‐718 expression level is inversely correlated with the lymph node metastasis and TNM stage. Also, plasma miRNA‐718 might serve as a potential diagnostic marker for ESCC.…”

Section: Mirna As Biomarkers In Esophageal Cancermentioning

confidence: 99%

Circulating microRNAs as diagnostic and therapeutic biomarkers in gastric and esophageal cancers

Jamali

Tofigh

Tutunchi

et al. 2018

Journal Cellular Physiology

137

119

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Gastric and esophageal cancers are as main cancers of the gastrointestinal (GI) tract, which are associated with poor diagnosis and survival. Several efforts were made in the past few decades to finding effective therapeutic approaches, but these approaches had several problems. Finding new biomarkers is a critical step in finding new approaches for the treatment of these cancers. Finding new biomarkers that cover various aspects of the diseases could provide a choice of suitable therapies and better monitoring of patients with these cancers. Among several biomarkers tissue specific and circulating microRNAs (miRNAs) have emerged as powerful candidates in the diagnosis of gastric and esophageal cancers. MiRNAs are small noncoding single-stranded RNA molecules that are found in the blood and regulate gene expression. These have numerous characteristics that make them suitable for being used as ideal biomarkers in cancer diagnosis. Research has indicated that the level and profile of miRNA in serum and plasma are very high. They are potentially noninvasive and sensitive enough to detect tumors in their primary stages of infection. Multiple lines of evidence indicate that the presence, absence, or deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer) are associated with initiation and progression of gastric and esophageal cancers. The aim of this review is to highlight the recent advances in the roles of miRNAs in diagnosis and treatment of gastric and esophageal cancers.

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“…As a consequence, 22 articles (22,23,(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53) were eventually included in the meta-analysis. Among them, 7 articles (22,38,39,46,47,51,52) studied more than one miRNA. A total of 2 articles (34,44) focused on different miRNAs in the same subjects and contained a validation group.…”

Section: Characteristics Of the Studies Included In The Meta-analysismentioning

confidence: 99%

Circulating plasma microRNAs in the detection of esophageal squamous cell carcinoma

Dong

Ren

et al. 2018

Oncol Lett

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Circulating microRNAs (miRNAs/miRs) have been reported as diagnostic biomarkers for esophageal cancer (EC) diagnosis. However, contrasting results have been achieved in different studies. In the present study, a meta-analysis was performed, based on the systematic search of PubMed and Web of Science, to evaluate the diagnostic value of circulating miRNAs in the peripheral blood in EC. The top 5 most-studied miRNAs were selected for confirmation by reverse transcription quantitative-polymerase chain reaction using the blood plasma of 125 patients with esophageal squamous cell carcinoma (ESCC) and 125 healthy individuals from Henan, China. A total of 45 studies from 22 articles, regarding 33 miRNAs were considered in the meta-analysis. The pooled sensitivity and specificity were both 0.79 (95% confidence interval, 0.76-0.82 for both). Among the 5 miRNAs considered (miR-21, miR-223, miR-375, miR-25 and miR-100), miR-21 and miR-223 were significantly overexpressed whereas miR-375 expression was reduced in patients with ESCC compared with healthy individuals (all P<0.001). The areas under the curves (AUCs) were 0.80, 0.73, and 0.69 for miR-21, miR-223, and miR-375, respectively. The AUCs increased when discriminating between patients with early ESCC in stage 0-I and the non-invasive carcinoma stage Tis-T1 stage from controls. Thus, it was concluded that plasma miR-21, miR-223 and miR-375 may serve as non-invasive diagnostic biomarkers in patients with ESCC, especially early ESCC in stages 0-I and Tis-T1.

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Predictive value of plasma miRNA-718 for esophageal squamous cell carcinoma

Abstract: Plasma miRNA-718 is downregulated in ESCC patients and might serve as a potential diagnostic marker for ESCC.

Cited by 21 publications

References 0 publications

Identification of molecular targets for esophageal carcinoma diagnosis using miRNA-seq and RNA-seq data from The Cancer Genome Atlas: a study of 187 cases

Identification of molecular targets for esophageal carcinoma diagnosis using miRNA-seq and RNA-seq data from The Cancer Genome Atlas: a study of 187 cases

Circulating microRNAs as diagnostic and therapeutic biomarkers in gastric and esophageal cancers

Circulating plasma microRNAs in the detection of esophageal squamous cell carcinoma

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