Predictive value of NT-pro BNP after acute myocardial infarction: Relation with acute and chronic infarct size and myocardial function

Mayr, Agnes; Mair, Johannes; Schocke, Michael; Klug, Gert; Pedarnig, Kathrin; Haubner, Bernhard J.; Nowosielski, Martha; Grubinger, Thomas; Pachinger, Otmar; Metzler, Bernhard

doi:10.1016/j.ijcard.2009.09.537

Cited by 81 publications

(64 citation statements)

References 45 publications

(48 reference statements)

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“…Brain natriuretic peptide (BNP) is a 32-amino-acid ringshaped polypeptide that increases the urinary excretion of water and sodium, relaxes blood vessels and inhibits sympathetic activity (3)(4)(5)(6)(7). Since its use as a drug for heart failure in 2001 (8), recombinant human brain natriuretic peptide (rhBNP) has been increasingly used for the treatment of AMI, accompanied by cardiac insufficiency.…”

Section: Introductionmentioning

confidence: 99%

Effects of recombinant human brain natriuretic peptide on the prognosis of patients with acute anterior myocardial infarction undergoing primary percutaneous coronary intervention: a prospective, multi-center, randomized clinical trial

et al. 2017

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Background: This study aims to investigate the effects of recombinant human brain natriuretic peptide (rhBNP) on serum enzyme data, cardiac function parameters and cardiovascular events in patients with acute anterior myocardial infarction (MI). Methods: A total of 421 patients with acute anterior or extensive anterior MI were collected from 20 hospitals. These patients were randomly divided into two groups: rhBNP and control groups. Both groups of patients received primary percutaneous coronary intervention (PCI) within the effective time window.In the rhBNP group, rhBNP administration (0.01 µg/kg/min, 48-72 successive hours) was performed as early as possible after hospital admission. Prior to and one or seven days after PCI, serum concentrations of cardiac troponin (cTnT), creatine kinase-MB (CK-MB) and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured. At seven days and 6 months after PCI, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd) and stroke volume (SV) were measured using 2D Doppler echocardiography. MACEs that occurred during hospitalization and within 6 months after PCI were recorded. Results: At postoperative days one and seven, serum concentrations of cTnT were significantly lower in the rhBNP group than in the control group. At postoperative day one, serum concentrations of CK-MB were significantly lower in the rhBNP group than in the control group. At postoperative day seven, serum concentrations of NT-proBNP were significantly lower in the rhBNP group than in the control group, and LVEF was significantly greater in the rhBNP group than in the control group. At postoperative 6 months, LVEDd was significantly lower in the rhBNP group compared with the control group. In addition, SV and LVEF were significantly greater in the rhBNP group than in the control group. By postoperative month 6, the incidence of composite cardiovascular events (16.0% vs. 26.0%, P=0.012), cardiac death (7.0% vs.13.5%, P=0.030), and particularly cardiac death + re-hospitalization for congestive heart failure (13.1% vs. 25.5%, P=0.001) were significantly lower in the rhBNP group than in the control group.Conclusions: Early intravenous rhBNP administration after PCI significantly lowered the serum concentrations of cTnT and NT-proBNP, increased LVEDd, SV and LVEF, and reduced MACEs, including cardiac death, in patients with acute anterior MI undergoing PCI.

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Section: Introductionmentioning

confidence: 99%

Effects of recombinant human brain natriuretic peptide on the prognosis of patients with acute anterior myocardial infarction undergoing primary percutaneous coronary intervention: a prospective, multi-center, randomized clinical trial

et al. 2017

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“…Nijveldt et al (2008) reported that BNP was more strongly correlated with necrotic cardiac muscles than with ischemic cardiac muscles, and Grabowski et al (2007) reported that BNP was more informative than other clinical indexes, such as the Killip grade, TIMI risk points, etc. Mayr et al (2011) found that the NT-proBNP concentration was closely correlated with heart function and could accurately predict chronic MI size after 3 days of MI, and that the heart function of the patients could not recover if the NT-proBNP level was >1115 pg/mL. Mistry et al (2011) reported that the NT-proBNP plasma concentration showed a stronger correlation when AMI occurred within 3 months compared to only 3 days.…”

Section: Discussionmentioning

confidence: 99%

“…Some researchers have reported a correlation between the plasma concentration of BNP and myocardial infarct (MI) size in patients with acute myocardial infarction (AMI). Mayr et al (2011) and Mistry et al (2011) evaluated the correlation between BNP and MI size after 66 ± 8 h, 3 months, and 3 days from AMI occurrence, respectively. However, the stage at which BNP in AMI can best reflect the MI size is still under investigation.…”

Section: Introductionmentioning

confidence: 99%

Association of plasma B-type natriuretic peptide concentration with myocardial infarct size in patients with acute myocardial infarction

Niu¹,

Ma²,

Xie³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. B-type natriuretic peptide (BNP) is widely used in the treatment of early-stage heart failure and coronary heart disease. In this study, the association of plasma BNP concentration with myocardial infarct (MI) size in patients with acute myocardial infarction (AMI) was investigated. Eighty patients with AMI were enrolled in the MI group and 30 healthy volunteers were selected as the control group. Magnetic resonance imaging of the heart and plasma BNP concentration detection were carried out, and then the relationship between plasma BNP concentration and MI size was analyzed in the two groups. Results showed that the plasma BNP concentration was positively related to MI size (r = 0.645, P < 0.0005), whereas it was negatively correlated to the left ventriculus ejection fraction (r = 0.297, P = 0.047). Multiple regression analysis showed that MI size was the only parameter that was independently associated with BNP (r 2 = 0.32, F = 7.712, P = 0.007). Moreover, when the BNP level reached 150 pg/mL, it had 85.1% sensitivity and 70.4% specificity of determining MI sizes exceeding 10%. The plasma concentration of BNP is highly related to MI size in patients with AMI, and can be clinically used to evaluate MI size.

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“…Cardiac troponin measured with standard (3) and high-sensitive (4) assays has improved our abilities to define patients with acute coronary syndromes (5), estimate the amount of myocardial necrosis (3), predict functional impairment (6,7) and prognosis (8). Another well-established biomarker in acute coronary syndromes is NT-pro-BNP (9). Today these two biomarkers impact clinical decisions of cardiologist every day.…”

Section: Recently Navickas Et Al Published a Review On The Role Of Mmentioning

confidence: 99%

The role of circulating microRNAs in acute coronary syndromes: ready for prime time?

Klug

Metzler

2016

Ann. Transl. Med.

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Predictive value of NT-pro BNP after acute myocardial infarction: Relation with acute and chronic infarct size and myocardial function

Cited by 81 publications

References 45 publications

Effects of recombinant human brain natriuretic peptide on the prognosis of patients with acute anterior myocardial infarction undergoing primary percutaneous coronary intervention: a prospective, multi-center, randomized clinical trial

Effects of recombinant human brain natriuretic peptide on the prognosis of patients with acute anterior myocardial infarction undergoing primary percutaneous coronary intervention: a prospective, multi-center, randomized clinical trial

Association of plasma B-type natriuretic peptide concentration with myocardial infarct size in patients with acute myocardial infarction

The role of circulating microRNAs in acute coronary syndromes: ready for prime time?

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