Predictive value of neutrophil to lymphocyte and platelet to lymphocyte ratio in COVID-19

Zhu, Shiping; Dong, Lei; Cai, Wanru

doi:10.1186/s13054-020-03258-x

Cited by 13 publications

(12 citation statements)

References 4 publications

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“…Potential causes for this finding of relative lymphopenia are the inflammatory cytokine storm, exhaustion of T cells, infection of T cells, and interference with T cell expansion [ 26 ]. Zhu et al note that in addition to a high neutrophil to lymphocyte ratio, a low ratio may also be associated with mortality, indicating a nonlinear association with acuity [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Cohort Study of Clinical Factors Associated with Transitions of Care among COVID-19 Patients

Swearingen

Boverman

Tgavalekos

et al. 2021

JCM

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Coronavirus Disease 2019 (COVID-19) is an international health crisis. In this article, we report on patient characteristics associated with care transitions of: 1) hospital admission from the emergency department (ED) and 2) escalation to the intensive care unit (ICU). Analysis of data from the electronic medical record (EMR) was performed for patients with COVID-19 seen in the ED of a large Western U.S. Health System from April to August of 2020, totaling 10,079 encounters. Of these, 5172 resulted in admission as an inpatient within 72 h. Inpatient encounters (n = 6079) were also considered for patients with positive COVID-19 test results, of which 970 resulted in a transfer to the ICU or in-hospital mortality. Laboratory results, vital signs, symptoms, and comorbidities were investigated for each of these care transitions. Different top risk factors were found, but two factors common to hospital admission and ICU transfer were respiratory rate and the need for oxygen support. Comorbidities common to both settings were cerebrovascular disease and congestive heart failure. Regarding laboratory results, the neutrophil-to-lymphocyte ratio was associated with transitions to higher levels of care, along with the ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT).

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Section: Discussionmentioning

confidence: 99%

A Retrospective Cohort Study of Clinical Factors Associated with Transitions of Care among COVID-19 Patients

Swearingen

Boverman

Tgavalekos

et al. 2021

JCM

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“…Neutrophil production and elimination must be strictly regulated, since low levels of neutrophils (neutropenia) result in recurrent infection and systemic inflammation, while high levels of neutrophils (neutrophilia) also lead to an inflammatory state, due to cytotoxic damage of the healthy tissue [ 22 ]. COVID-19 cohort studies reported high levels of neutrophils and sustained low levels of lymphocyte counts in patients, leading to a high neutrophil-to-lymphocyte ratio (NLR), which is predictive for severe illness in the early stage of SARS-CoV-2 infection [ 23 ]. Lung autopsies of deceased patients displayed neutrophil infiltration into pulmonary capillaries, with extravasation into the alveolar area and neutrophilic mucositis.…”

Section: Neutrophils In Covid-19mentioning

confidence: 99%

P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo‐inflammation

Petiz

Glaser

Scharfstein

et al. 2021

Stem Cell Rev and Rep

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Graphical Abstract The global SARS-CoV-2 pandemic starting in 2019 has already reached more than 2.3 million deaths. Despite the scientific community’s efforts to investigate the COVID-19 disease, a drug for effectively treating or curing patients yet needs to be discovered. Hematopoietic stem cells (HSC) differentiating into immune cells for defense express COVID-19 entry receptors, and COVID-19 infection hinders their differentiation. The importance of purinergic signaling in HSC differentiation and innate immunity has been recognized. The metabotropic P2Y14 receptor subtype, activated by UDP-glucose, controls HSC differentiation and mobilization. Thereon, the exacerbated activation of blood immune cells amplifies the inflammatory state observed in COVID-19 patients, specially through the continuous release of reactive oxygen species and extracellular neutrophil traps (NETs). Further, the P2Y14 subtype, robustly inhibits the infiltration of neutrophils into various epithelial tissues, including lungs and kidneys. Here we discuss findings suggesting that antagonism of the P2Y14 receptor could prevent the progression of COVID-19-induced systemic inflammation, which often leads to severe illness and death cases. Considering the modulation of neutrophil recruitment of extreme relevance for respiratory distress and lung failure prevention, we propose that P2Y14 receptor inhibition by its selective antagonist PPTN could limit neutrophil recruitment and NETosis, hence limiting excessive formation of oxygen reactive species and proteolytic activation of the kallikrein-kinin system and subsequent bradykinin storm in the alveolar septa of COVID-19 patients.

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“…We thank Zhu et al 1 for their interest in our previous study on 'Blood eosinophil count as a predictor of hospital length of stay in COPD exacerbations'. 2…”

Section: Replymentioning

confidence: 99%

Predictive value of blood eosinophil count in COPD

Zhu

Cai

2021

Respirology

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Predictive value of neutrophil to lymphocyte and platelet to lymphocyte ratio in COVID-19

Cited by 13 publications

References 4 publications

A Retrospective Cohort Study of Clinical Factors Associated with Transitions of Care among COVID-19 Patients

A Retrospective Cohort Study of Clinical Factors Associated with Transitions of Care among COVID-19 Patients

P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo‐inflammation

Predictive value of blood eosinophil count in COPD

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