Predictive value of in vitro radiosensitivity parameters in head and neck cancers and cervical carcinomas: Preliminary correlations with local control and overall survival

Girinsky, T.; Lubin, R.; Pignon, Jean-Pierre; Chavaudra, N.; Gazeau, J; Dubray, Bernard; Cosset, Jean‐Marc; Socié, Gèrard; Fertil, Bernard

doi:10.1016/0360-3016(93)90137-k

Cited by 92 publications

(41 citation statements)

References 6 publications

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“…In addition, we have found that the radiosensitivity of head and neck cancers is independent of many clinical parameters, i.e. stage, nodal status and patient age, and this confirms the findings of others (Brock et al, 1992;Girinsky et al, 1993Girinsky et al, , 1994. This study also confirmed the finding that there are no significant differences in mean radiosensitivity for tumours of different sites within the head and neck region (Girinsky et al, 1993;Pekkola-Heino et al, 1995).…”

Section: Discussionsupporting

confidence: 91%

“…stage, nodal status and patient age, and this confirms the findings of others (Brock et al, 1992;Girinsky et al, 1993Girinsky et al, , 1994. This study also confirmed the finding that there are no significant differences in mean radiosensitivity for tumours of different sites within the head and neck region (Girinsky et al, 1993;Pekkola-Heino et al, 1995). The latter observation, however, is in contrast to a report by Brock et al (1992), who found that oral cavity tumours were more radioresistant than carcinomas of the larynx, an observation that is consistent with clinical observations (Corv6 et al, 1994).…”

Section: Discussionsupporting

confidence: 91%

“…The latter figure is similar to the 60% success rate reported by Brock et al (1990) for primary head and neck carcinomas using the CAM assay. Girinsky et al (1993) reported a success rate for obtaining SF, values in head and neck cancers using the CAM assay of 75% when the cell yield was high enough to allow cell cultures to be set up. Using the same criteria we also obtained a success rate of 74% in obtaining SF, measurements.…”

Section: Discussionmentioning

confidence: 99%

“…tests. However, intrinsic radiosensitivity expressed as parameters of the low-dose region of radiation cell survival curves is thought to be one of the most important and significant factors determining the response of a tumour to radiation treatment (Deacon et al, 1984;Fertil and Malaise, 1985;Tucker and Thames, 1989;Brock et al, 1990Brock et al, , 1992Davidson et al, 1990;West and Hendry 1992;West et al, 1993West et al, , 1997Girinsky et al, 1993Girinsky et al, , 1994.…”

Section: Sf2mentioning

confidence: 99%

“…For patients treated with post-operative radiotherapy, SF2 was not predictive of treatment outcome (Brock et al, 1990(Brock et al, , 1992. However, in a study in which the majority of patients were treated with radiotherapy alone, tumour radiosensitivity was a significant prognostic factor (Girinsky et al, 1993(Girinsky et al, , 1994. Work using a soft-agar clonogenic assay to measure SF2 on cervical cancers undergoing radical radiotherapy has shown that tumour radiosensitivity is a highly significant and independent prognostic factor for both local control and overall survival (West et al, 1993(West et al, , 1997.…”

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confidence: 99%

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The in vitro radiosensitivity of human head and neck cancers

Björk‐Eriksson

West²,

Karlsson³

et al. 1998

Br J Cancer

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Summary A study was made of the intrinsic radiosensitivity of 140 biopsy and surgical specimens of malignant head and neck tumours of different histologies. Using a soft-agar clonogenic assay, the material was assessed for the ability to grow in culture (colony-forming efficiency; CFE) and inherent tumour radiosensitivity (surviving fraction at 2 Gy, SF2). The success rate for obtaining growth was 74% (104/140) with a mean CFE of 0.093% (median 0.031) and a range of 0.002-1.3%. SF2 was obtained for 88 of 140 specimens, representing a success rate of 63% with a mean SF2 of 0.48 (median 0.43) and a range of 0.10-1.00. There were no significant differences in radiosensitivity between different sites of the head and neck region. There were no significant relationships between SF2 and disease stage, nodal status, tumour grade, patient age, primary tumour growth pattern and CFE. The results were compared with those for other tumour types previously analysed with the same assay. The distribution of the SF2 values for the head and neck tumours was similar to that for 145 cervix carcinomas and there was no significant difference in mean radiosensitivity between the two tumour types. Also, there was no significant difference in radiosensitivity between head and neck tumours and either breast or colorectal cancers. However, a group of eight lymphomas was significantly more radiosensitive. These results confirm the feasibility of carrying out radiosensitivity measurements using a soft-agar clonogenic assay on head and neck tumours. In addition, the work has shown that radiosensitivity is independent of many clinical parameters and that the mean value is similar to that reported for cervix carcinomas.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Sf2mentioning

confidence: 99%

mentioning

confidence: 99%

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The in vitro radiosensitivity of human head and neck cancers

Björk‐Eriksson

West²,

Karlsson³

et al. 1998

Br J Cancer

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Comparison between the in vitro intrinsic radiation sensitivity of human soft tissue sarcoma and breast cancer cell lines

et al. 1996

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Severe normal tissue complication correlates with increased in vitro fibroblast radiosensitivity in radical prostate radiotherapy: A case report

et al. 2000

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The radiation responses of fibroblasts taken from four patients undergoing radiotherapy for prostate cancer were evaluated in vitro. One patient exhibited a severe normal tissue late reaction after radiotherapy, and the fibroblasts from this patient also showed increased radiosensitivity. The other three patients exhibited a normal clinical response, and their fibroblast response in vitro was also considered normal when compared with previously published data from our laboratory. When cells were allowed to repair potentially lethal damage (PLDR), the differences between cell lines were reduced; therefore, a deficiency in PLDR did not cause the differences in radiosensitivity. Fractionated radiation resulted in elevated survival due to repair of sublethal damage (SLDR), and the differences in radiosensitivity were increased. In addition, the survival curves displayed an upward bending nature, indicative of an adaptive response. Thus, adaptive response and ability to modify it may play an important role in fractionated radiotherapy.

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Predictive value of in vitro radiosensitivity parameters in head and neck cancers and cervical carcinomas: Preliminary correlations with local control and overall survival

Cited by 92 publications

References 6 publications

The in vitro radiosensitivity of human head and neck cancers

The in vitro radiosensitivity of human head and neck cancers

Comparison between the in vitro intrinsic radiation sensitivity of human soft tissue sarcoma and breast cancer cell lines

Severe normal tissue complication correlates with increased in vitro fibroblast radiosensitivity in radical prostate radiotherapy: A case report

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