Predictive value of fractional nitric oxide in asthma diagnosis-subgroup analyses

The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management

“…There are some data to suggest that FeNO compares favorably to other predictive tests to address the challenges in such children. [15][16][17] In individuals who have been diagnosed with asthma, FeNO may be useful to predict which treatments are likely to be most helpful to a given patient, to follow the response to treatment, or to aid in the assessment of adherence to certain therapies (e.g., inhaled corticosteroids). 18 Ascertaining whether a patient has 'responded" to a given therapy can be difficult, given the inherent variability in the disease, the non-specific nature of many measures of response, and the time required to demonstrate an effect of treatment.…”

Clinical features in patients of cough variant asthma with normal and high level of exhaled fractional nitric oxide

“…This finding is consistent with results from numerous studies that reported higher FeNO levels in allergic than non-allergic subjects, in both children and adults. 3,4 Concomitant perennial allergic rhinitis has also been associated with higher FeNO levels and a higher percentage of eosinophils in the sputum and blood of patients with classic asthma and has also been linked to increased asthma severity. 19 In our study, the subjects were younger in the high FeNO group compared with the normal group, which may be due to a higher prevalence of allergies in younger compared with the older age groups.…”

“…20 Numerous studies have shown that in individuals with asthma, increased FeNO levels are associated with eosinophilia in the blood, sputum, bronchoalveolar fluid and airway mucosa. 3,4 Concomitant perennial allergic rhinitis has also been associated with higher FeNO levels and a higher percentage of eosinophils in the sputum and blood of patients with classic asthma and has also been linked to increased asthma severity. FeNO levels also correlated with a higher percentage of eosinophils in the sputum of patients with CVA.…”

“…3,4 Levels of FeNO have been found to be elevated in patients with bronchial asthma and cough variant asthma, but not in nonallergic cough. 3,4 Levels of FeNO have been found to be elevated in patients with bronchial asthma and cough variant asthma, but not in nonallergic cough.…”

“…Fractional exhaled nitric oxide (FeNO) is known to be a convenient, sensitive marker that can be measured noninvasively to monitor eosinophilic and Th2 type lower airway inflammation. 3,4 Levels of FeNO have been found to be elevated in patients with bronchial asthma and cough variant asthma, but not in nonallergic cough. 5,6 In clinical practice, we have observed that a significant number of patients with CVA have FeNO values within the normal range.…”