Predictive value of clinical characteristics in eosinophilic chronic rhinosinusitis with nasal polyps: A cross‐sectional study in the Chinese population

Yu, Longgang; Jiang, Yan; Yan, Bing; Fang, Gao‐Li; Zhang, Luo

doi:10.1002/alr.22901

Cited by 9 publications

(3 citation statements)

References 46 publications

(98 reference statements)

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“…[8] However, none of these reports were conducted exclusively in patients with CRSwNP, which is of utmost importance, as these patients have a fluctuating sense of smell. [9] It has also been reported that these patients who are more aware of their sense of smell obtain better correlations between the subjective and instrumental assessment. [8] In fact, the frequency of unawareness of OD was only 16% in CRS, [10] much lower than the 30% reported by Lötsch and Hummel(8) in a non-selected population, or 77% in elderly individuals.…”

Section: Introductionmentioning

confidence: 90%

Validation of Visual Analogue Scale for loss of smell as a quick test in chronic rhinosinusitis with nasal polyps

Alobid,

Calvo-Henríquez,

Viveros-Díez

et al. 2023

J Investig Allergol Clin

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INTRODUCTION/OBJECTIVE: Diagnostic criteria of chronic rhinosinusitis with nasal polyps (CRSwNP) include, among others, olfactory dysfunction (OD). We hypothesize that patients suffering with CRSwNP are good at self-assessing their sense of smell through visual analogue scale (VAS) compared to smell tests. METHODS: A controlled cross-sectional study was planned. Adults diagnosed with severe CRSwNP waiting for endoscopic sinus surgery were included. A cohort of healthy controls was also studied. All participants performed Barcelona smell test (BAST-24), sinonasal outcomes test 22 (SNOT-22), and VAS for loss of smell. CRSwNP underwent blood test (eosinophils count, total serum IgE), CT scan (Lund-Mackay Score), and nasal endoscopy. RESULTS: 138 severe CRSwNP and 40 controls subjects were included. The BAST-24 identification score was strongly correlated with the VAS score in the CRSwNP group (rho=-0.79, p<0.001) but not in the control group (rho=-0.14; p=0.39), this difference between groups being statistically significant (p<0.001). A significant correlation of SNOT-22 item 21 (loss of smell) was also found with BAST-24 identification (rho=-0.65, p<0.001), this difference being statistically significant (Z=-2.43; p=0.015). In the ROC curve, the area under the curve (AUC) was 0.85 with 72.5% sensitivity and 93.1% specificity. CONCLUSION. This study demonstrates a potential role of the VAS score for the screening of OD in severe CRSwNP in daily clinical practice.

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Section: Introductionmentioning

confidence: 90%

Validation of Visual Analogue Scale for loss of smell as a quick test in chronic rhinosinusitis with nasal polyps

Alobid,

Calvo-Henríquez,

Viveros-Díez

et al. 2023

J Investig Allergol Clin

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“…CRSwNP is generally divided into eosinophilic CRSwNP (ECRSwNP) and noneosinophilic CRSwNP (nECRSwNP) based on the degree of eosinophil infiltration ( 3 – 5 ). Caucasian CRSwNP patients tend to exhibit greater eosinophilic inflammation than Asian patients, while the prevalence of ECRSwNP is increasing in Asian countries ( 6 , 7 ). Currently, the etiology of CRSwNP has not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

The oxidant-antioxidant imbalance was involved in the pathogenesis of chronic rhinosinusitis with nasal polyps

Zhou,

Liu

et al. 2024

Front. Immunol.

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BackgroundAlthough oxidative stress is involved in the pathophysiological process of chronic rhinosinusitis with nasal polyps (CRSwNP), the specific underlying mechanism is still unclear. Whether antioxidant therapy can treat CRSwNP needs further investigation.MethodsImmunohistochemistry, immunofluorescence, western blotting and quantitative polymerase chain reaction (qPCR) analyses were performed to detect the distribution and expression of oxidants and antioxidants in nasal polyp tissues. qPCR revealed correlations between oxidase, antioxidant enzymes and inflammatory cytokine levels in CRSwNP patients. Human nasal epithelial cells (HNEpCs) and primary macrophages were cultured to track the cellular origin of oxidative stress in nasal polyps(NPs) and to determine whether crocin can reduce cellular inflammation by increasing the cellular antioxidant capacity.ResultsThe expression of NOS2, NOX1, HO-1 and SOD2 was increased in nasal epithelial cells and macrophages derived from nasal polyp tissue. Oxidase levels were positively correlated with those of inflammatory cytokines (IL-5 and IL-6). Conversely, the levels of antioxidant enzymes were negatively correlated with those of IL-13 and IFN-γ. Crocin inhibited M1 and M2 macrophage polarization as well as the expression of NOS2 and NOX1 and improved the antioxidant capacity of M2 macrophages. Moreover, crocin enhanced the ability of antioxidants to reduce inflammation via the KEAP1/NRF2/HO-1 pathway in HNEpCs treated with SEB or LPS. Additionally, we observed the antioxidant and anti-inflammatory effects of crocin in nasal explants.ConclusionOxidative stress plays an important role in the development of CRSwNP by promoting various types of inflammation. The oxidative stress of nasal polyps comes from epithelial cells and macrophages. Antioxidant therapy may be a promising strategy for treating CRSwNP.

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“…Studies have found that the comorbidity rate of asthma and allergic rhinitis were higher in the eCRSwNP subgroup than in the non-eCRSwNP subgroup. 17 18 However, Hu et al . 19 found that although the association of eCRSwNP with asthma is widely accepted, there was no significant statistical difference between the rate of coexistence of asthma in eosinophilic and non-eCRSwNP.…”

Section: Introductionmentioning

confidence: 99%

Development, Validation and Comparison of Artificial Neural Network and Logistic Regression Models Predicting Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Zhou

Fan

Qin

et al. 2023

Allergy Asthma Immunol Res

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Purpose Chronic rhinosinusitis with nasal polyps (CRSwNP) can be classified into eosinophilic CRSwNP (eCRSwNP) and non-eosinophilic CRSwNP (non-eCRSwNP) by tissue biopsy, which is difficult to perform preoperatively. Clinical biomarkers have predictive value for the classification of CRSwNP. We aimed to evaluate the application of artificial neural network (ANN) modeling in distinguishing different endotypes of CRSwNP based on clinical biomarkers. Methods Clinical parameters were collected from 109 CRSwNP patients, and their predictive ability was analyzed. ANN and logistic regression (LR) models were developed in the training group (72 patients) and further tested in the test group (37 patients). The output variable was the diagnosis of eCRSwNP, defined as tissue eosinophil count > 10 per high-power field. The receiver operating characteristics curve was used to assess model performance. Results A total of 15 clinical features from 60 healthy controls, 60 eCRSwNP and 49 non-eCRSwNP were selected as candidate predictors. Nasal nitric oxide levels, peripheral eosinophil absolute count, total immunoglobulin E, and ratio of bilateral computed tomography scores for the ethmoid sinus and maxillary sinus were identified as important features for modeling. Two ANN models based on 4 and 15 clinical features were developed to predict eCRSwNP, which showed better performance, with the area under the receiver operator characteristics significantly higher than those from the respective LR models (0.976 vs. 0.902, P = 0.048; 0.970 vs. 0.845, P = 0.011). All ANN models had better fits than single variable prediction models (all P < 0.05), and ANN model 1 had the best predictive performance among all models. Conclusions Machine learning models assist clinicians in predicting endotypes of nasal polyps before invasive detection. The ANN model has the potential to predict eCRSwNP with high sensitivity and specificity, and is superior to the LR model. ANNs are valuable for optimizing personalized patient management.

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Predictive value of clinical characteristics in eosinophilic chronic rhinosinusitis with nasal polyps: A cross‐sectional study in the Chinese population

Cited by 9 publications

References 46 publications

Validation of Visual Analogue Scale for loss of smell as a quick test in chronic rhinosinusitis with nasal polyps

Validation of Visual Analogue Scale for loss of smell as a quick test in chronic rhinosinusitis with nasal polyps

The oxidant-antioxidant imbalance was involved in the pathogenesis of chronic rhinosinusitis with nasal polyps

Development, Validation and Comparison of Artificial Neural Network and Logistic Regression Models Predicting Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

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