Predictive value of C-reactive protein at different cutoff levels in acute appendicitis

Wu, Han-Ping; Lin, Ching‐Yuang; Chang, Chin-Fu; Chang, Yu-Jun; Huang, Chin-Yi

doi:10.1016/j.ajem.2004.10.013

Cited by 89 publications

(85 citation statements)

References 14 publications

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“…Fewer studies look at the differences between simple and perforated appendicitis. These studies found that LC, granulocyte count and the CRP-level have a discriminatory capacity for perforated appendicitis as compared to simple appendicitis [1,8,10,16]. In our study, CRP-levels weighted most heavily in the predictive model.…”

Section: Discussionmentioning

confidence: 69%

“…LC, CRP levels, ESR levels, days of symptoms and temperature were statistically significantly higher in patients with a perforated appendicitis. Most studies in the literature focus on predicting appendicitis [8,10,15,16]. Fewer studies look at the differences between simple and perforated appendicitis.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies in literature defined their perforated appendicitis group based on surgical reports. Fewer studies defined this group based on the histology report [10,13] and some combined the surgical report with the histology report [11]. Based on the literature and the ICD10 we chose to use the surgical report.…”

Section: Discussionmentioning

confidence: 99%

“…The perforated appendicitis group consisted of patients whose surgical report noticed a perforated appendix, abscess formation or purulent peritoneal fluid. There is controversy in literature on how to define a perforated appendicitis, which might either be based on the surgical report [2,4,7,9,14] or the histology report [10,13]. A second rationale for using the surgeon's findings as gold standard is that after-treatment is based upon the surgeon's opinion.…”

Section: Methodsmentioning

confidence: 99%

“…In children CRP values aid in the diagnosis of perforated appendicitis. Whether LC may discriminate simple from perforated appendicitis in the pediatric population remains uncertain [9][10][11][12][13]. Despite previous investigations it remains unclear whether LC, CRP levels and Erythrocyte Sedimentation Rate (ESR) levels combined with body temperature and duration of abdominal pain have a predictive value in diagnosing a perforated appendicitis in unselected patient groups.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Study of Acute and Perforated Appendicitis

Akhil¹

2017

MOJS

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Introduction: The aim of this study was to create a model for the identification of a perforated appendicitis. Patients and Method:All consecutive patients who have undergone an appendectomy in the DY Patil Medical Hospital, Pune between January 1, 2015 and July 31, 2017 were included in a retrospective cohort study. Baseline patient characteristics, history and laboratory data were collected. Variables discriminating perforated from non-perforated appendicitis were identified using univariate and multivariable analyses. These items were used to create a model to predict perforation.Results: A total of 498 patients were included in the study. In the univariate analysis leukocyte count (LC), C-Reactive Protein levels (CRP), Erythrocyte Sedimentation Rate levels (ESR), days of symptoms and temperature were identified as predictors of perforated appendicitis. A predictive model was created using CRP, LC, ESR, duration of abdominal pain, and temperature. The predicted probability (P) of a perforated appendicitis can be calculated from the following model: (P) = 1 / (1+e (-(-2.788 + 0.012* CRP + 0.207* days with complaints))). Conclusion:Perforation of appendicitis can be predicted from the CRP level and the duration of abdominal pain. These findings might influence the choice between conservative or surgical treatment of appendicitis, and could provide guidance in the early start of antibiotics. Keywords:

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative Study of Acute and Perforated Appendicitis

Akhil¹

2017

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Hyperbilirubinaemia in appendicitis: the diagnostic value for prediction of appendicitis and appendiceal perforation

Adams¹,

Jaunoo²

2015

Eur J Trauma Emerg Surg

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Bilirubin levels may be high, but remain within normal range, in cases of appendicitis. Therefore, bilirubin levels may be a useful measurement when investigating a patient with suspected appendicitis. Hyperbilirubinaemia is highly specific with regards to perforation, a finding supported by other studies. However, possibly because of the few perforated cases in this study, we cannot recommend that hyperbilirubinaemia be used to predict perforation.

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