Predictive Value of C-Reactive Protein for Early Postoperative Complications in Children After Hypospadias Surgery

Abstract

Background: This study explored the predictive value of postoperative C-reactive protein in children with hypospadias for postoperative complications and the risk factors.Methods: The clinical and follow-up data of 106 children with hypospadias who were treated with operations at Kunming Children's Hospital in 2020 were, respectively, analyzed. According to the occurrence of postoperative complications, the patients were divided into two groups: 25 patients with postoperative complications were the complications group, and 81 without postoperative complications were the control group. The baseline data, clinical characteristics, laboratory test indexes, and outcome of the two groups were collected. Receiver operating characteristic (ROC) was used to calculate the optimal cutoff value of C-reaction protein (CRP). Logistic regression was used to analyze the risk factors of hypospadias after surgery. A probability value (P) < 0.05 was considered statistically significant.Results: According to the result of the ROC curve, the optimal cutoff value of CRP was 11.7 mg/L. Logistic regression showed that the length of urethral defect, the urethral material, the operative produce, and the postoperative CRP level were related to the occurrence of postoperative complications of patients with DCC. The length of the urethral defect and the CRP level were the independent risk factors of the prognosis of hypospadias patients. The CRP level was related to the occurrence of postoperative complications and fistula.Conclusions: Postoperative CRP level can be used as a reliable marker for predicting the prognosis of hypospadias patients.

Risk factors and timing of complication presentation following primary hypospadias repair in adolescents

“…Our study found that LUD was an independent risk factor for hypospadias postoperative complications, which is consistent with previous studies 2,16–20 . Longer urethral defects require a greater amount of urethral repair material and a larger aspect ratio of the flap used in the urethral reconstruction.…”

“…15 Our study found that LUD was an independent risk factor for hypospadias postoperative complications, which is consistent with previous studies. 2,[16][17][18][19][20] Longer urethral defects require a greater amount of urethral repair material and a larger aspect ratio of the flap used in the urethral reconstruction. Consequently, ensuring sufficient blood supply for longer urethral defects becomes challenging, which hinders flap growth and anastomotic healing.…”

Current perspectives in hypospadias research: A scoping review of articles published in 2021 (Review)

“…Postoperative C-Reactive Protein value (24 h after surgery) is a reliable marker for a possible complication after hypospadias surgery (94).…”