Predictive Value of C-Reactive Protein to Albumin Ratio in ST-Segment Elevation Myocardial Infarction Patients Treated With Primary Percutaneous Coronary Intervention

Acet, Halit; Güzel, Tuncay; Aslan, Bayram; Işık, Mehmet; Ertaş, Faruk; Catalkaya, Sibel

doi:10.1177/0003319720963697

Cited by 18 publications

(23 citation statements)

References 43 publications

(53 reference statements)

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“…34 Acet et al found that the combination of CAR and The Global Registry of Acute Coronary Events score was an independent predictor of short-term major adverse cardiac events in STEMI patients undergoing primary PCI. 35 Native vessel diameter, grafted vessel, age of graft, gender, smoking, hyperlipidemia, hypertension, and diabetes mellitus are several predisposing factors for SVGD. Three separate process: thrombosis, intimal hyperplasia, and atherosclerosis may be involved in the pathogenesis of SVGD.…”

Section: Discussionmentioning

confidence: 99%

C-Reactive Protein to Albumin Ratio in Patients With Saphenous Vein Graft Disease

Yayla

2021

Angiology

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Atherosclerosis plays an important role in saphenous vein graft disease (SVGD). Previous studies showed that inflammatory blood cells play an active role in this process. C-reactive protein to albumin ratio (CAR) is considered as a novel predictor for cardiovascular risk and an indicator of inflammation. We aimed to assess the relationship between SVGD and CAR. A total of 711 participants with saphenous vein graft (SVG) were included; 348 patients had SVGD and 363 patients had patent (no stenosis) SVG. C-reactive protein to albumin ratio was higher in patients with SVGD ( P < .001). There was a significant positive correlation between CAR and the age of SVG (r = 0.123; P = .001) and SYNTAX score (r = 0.568; P < .001). Multivariate logistic regression analyses showed that lymphocyte count, CAR, and SYNTAX score were independent predictors of SVGD ( P < .05). C-reactive protein to albumin ratio may be a useful marker after bypass surgery to predict SVGD.

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Section: Discussionmentioning

confidence: 99%

C-Reactive Protein to Albumin Ratio in Patients With Saphenous Vein Graft Disease

Yayla

2021

Angiology

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“…23 Several studies have shown that the CRP level at admission is related to increased short-and long-term major adverse cardiac events (MACEs) in patients with acute coronary syndrome (ACS) treated with PCI. [24][25][26][27] In patients with ACS, the relationship between CRP and cardiovascular outcomes remains uncertain. A high level of CRP may be an indicator of a greater burden of myocardial ischemia and tissue damage.…”

Section: Discussionmentioning

confidence: 99%

“…10,11,35 Acet et al found that the combination of CAR and The Global Registry of Acute Coronary Events score was an independent predictor of short-term MACEs in STEMI patients undergoing primary PCI. 27 Kalyoncuoglu and Durmus showed that CAR is also useful for predicting the severity of CAD in non-STEMI patients. 36 In light of these results, it is reasonable to predict an association between CAR and coronary flow in patients with STEMI.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between C-Reactive Protein to Albumin Ratio and Infarct-Related Artery Patency in Patients With ST-Segment Elevation Myocardial Infarction

Yayla

Erdöl

et al. 2021

Angiology

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The C-reactive protein to albumin ratio (CAR) is a predictive marker of systemic inflammatory state in atherosclerotic coronary disease when compared with the predictive value of these 2 markers separately. We investigated the relationship between CAR and infarct-related artery (IRA) patency in patients with ST-segment elevation myocardial infarction (STEMI). The study population (n = 1047) was divided into 2 groups according to IRA patency which was assessed by the Thrombolysis in Myocardial Infarction (TIMI) flow grade. Nonpatent flow was defined as TIMI grade 0 (no-reflow), 1, and 2 flows, and normal flow was defined as TIMI 3 flow. There was a significant positive correlation between CAR and SYNTAX score ( r = 0.312, P < .001) and a negative correlation between CAR and TIMI grade flow ( r = −0.210, P < .001). At a cutoff level of 0.693, the CAR predicted TIMI no-reflow with a sensitivity of 65.4% and a specificity of 65.5% (area under the curve: 0.670, 95% CI: 0.62-0.71, P < .001). Multivariate logistic regression analyses showed that CAR was an independent predictor of IRA patency (0.003 [0.001-0.029]; P < .001). A higher CAR is a significant and independent predictor of IRA patency in patients with STEMI.

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“…CAR is a biomarker that has been studied as a prognostic marker in inflammatory and infectious diseases, and malignancy [14][15]. In the current literature, there are studies on the predictive ability of CAR in patients with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the ability of the C-reactive protein-to-albumin ratio to predict short-term mortality in patients with COVID-19

Özdemir

Algın

2021

J CLIN MED KAZ

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This study aimed to determine the ability of the C-reactive protein (CRP)-to-albumin ratio (CAR) to predict short-term mortality in patients with COVID-19.Material and methods: This retrospective, observational, cohort study included patients with COVID-19. The patients' demographics, clinical characteristics, CRP, albumin, CAR, blood urea nitrogen, creatinine, highsensitive cardiac troponin I and all-cause mortality within 30 days after admission were noted. The receiver operating characteristic curve analysis was performed, and odds ratios (OR) were calculated to determine the discriminative ability of the parameters.Results: A total of 103 patients with a median of age of 57 (25th -75th percentiles: 32-76) years were included in the study. The rate of 30-day mortality was 4.8% for the study cohort. According to the best Youden's index, the cutoff value for CRP was determined as 66.67 (sensitivity: 80%, specificity: 78.6%), and the area under curve (AUC) value was 0.801 (95% confidence interval [CI]: 71.1-87.3). According to the best Youden's index, the cut-off value for CAR was 0.18 (sensitivity: 80%, specificity: 78.6%), and the AUC value was 0.806 (95% CI: 71.6-87.7). There was no statistically significant difference between the AUC values of CRP and CAR (DeLong equality test, p=0.938). The OR of CRP (>66.67 mg/L) and CAR (>0.18) for 30-day mortality were 14.667 (95% CI: 1.555-138.299) and 13.818 (95% CI: 1.468-130.076), respectively.Conclusion: CAR was not useful in predicting 30-day mortality in patients with COVID-19. The calculation of CAR rather than CRP had no clinically significant contribution to the prediction of 30-day mortality in this patient group.

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Predictive Value of C-Reactive Protein to Albumin Ratio in ST-Segment Elevation Myocardial Infarction Patients Treated With Primary Percutaneous Coronary Intervention

Cited by 18 publications

References 43 publications

C-Reactive Protein to Albumin Ratio in Patients With Saphenous Vein Graft Disease

C-Reactive Protein to Albumin Ratio in Patients With Saphenous Vein Graft Disease

Relationship Between C-Reactive Protein to Albumin Ratio and Infarct-Related Artery Patency in Patients With ST-Segment Elevation Myocardial Infarction

Evaluation of the ability of the C-reactive protein-to-albumin ratio to predict short-term mortality in patients with COVID-19

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