Predictive Value of Bowel Ultrasound in Crohn’s Disease: A 12-Month Prospective Study

Allocca, Mariangela; Craviotto, Vincenzo; Bonovas, Stefanos; Furfaro, Federica; Zilli, Alessandra; Peyrin–Biroulet, Laurent; Fiorino, Gionata; Danese, Silvio

doi:10.1016/j.cgh.2021.04.029

Cited by 36 publications

(39 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All this in a very large cohort of patients with Crohn's disease (225 patients, as far as we know the largest cohort never assessed). 8 Now we have demonstrated that BUSS is able to detect relevant changes of inflammatory lesions over time. 1 We agree with Dr Goodsall and Dr Bryant that central reading will be crucial when we use the BUSS in multicentre study to limit any bias related to interpretation of parameters and that BUSS should be validated.…”

Section: N V I T E D E D I T O R I a Lmentioning

confidence: 90%

Editorial: an accurate, reliable and responsive ultrasound activity score for Crohn’s disease? Sounds good to US. Authors' reply

Allocca

Danese

2022

Aliment Pharmacol Ther

Self Cite

View full text Add to dashboard Cite

show abstract

Section: N V I T E D E D I T O R I a Lmentioning

confidence: 90%

Editorial: an accurate, reliable and responsive ultrasound activity score for Crohn’s disease? Sounds good to US. Authors' reply

Allocca

Danese

2022

Aliment Pharmacol Ther

Self Cite

View full text Add to dashboard Cite

show abstract

“…Firstly, baseline BWT (per 1 mm increase: OR 2.11; p < 0.001) and the presence of BWF (OR 5.24; p < 0.001) were shown as independent predictors for a baseline SES-CD > 2 [63]. Additionally, the authors designed a bowel US score (BUSS) combining BWT and BWF to assess disease activity [63]. A BUS score higher than 3.52 and the presence of any CD complications, such as strictures, abscesses and fistulas, at baseline BUS were identified as independent predictors of negative outcome at 12 months (OR 6.97; p < 0.001 and OR 3.90; p = 0.021, respectively) [63].…”

Section: Predicting Outcomes and Monitoringmentioning

confidence: 95%

“…In particular, a BWT value ≥ 5.5 mm had high sensitivity and specificity (84% and 98%) in predicting a severe post-surgical recurrence (defined as Rutgeerts score ≥ 3) [62]. Recently, a 12-month prospective, observational, two-phase study was carried out on the role of baseline BUS findings in predicting CD course [63]. Firstly, baseline BWT (per 1 mm increase: OR 2.11; p < 0.001) and the presence of BWF (OR 5.24; p < 0.001) were shown as independent predictors for a baseline SES-CD > 2 [63].…”

Section: Predicting Outcomes and Monitoringmentioning

confidence: 99%

“…Recently, a 12-month prospective, observational, two-phase study was carried out on the role of baseline BUS findings in predicting CD course [63]. Firstly, baseline BWT (per 1 mm increase: OR 2.11; p < 0.001) and the presence of BWF (OR 5.24; p < 0.001) were shown as independent predictors for a baseline SES-CD > 2 [63]. Additionally, the authors designed a bowel US score (BUSS) combining BWT and BWF to assess disease activity [63].…”

Section: Predicting Outcomes and Monitoringmentioning

confidence: 99%

“…Additionally, the authors designed a bowel US score (BUSS) combining BWT and BWF to assess disease activity [63]. A BUS score higher than 3.52 and the presence of any CD complications, such as strictures, abscesses and fistulas, at baseline BUS were identified as independent predictors of negative outcome at 12 months (OR 6.97; p < 0.001 and OR 3.90; p = 0.021, respectively) [63]. Of note, a subgroup analysis showed BUS score was also significantly predictive of a negative course at 12 months in CD patients in endoscopic remission (p < 0.003) [63].…”

Section: Predicting Outcomes and Monitoringmentioning

confidence: 99%

See 2 more Smart Citations

Cross-Sectional Imaging Instead of Colonoscopy in Inflammatory Bowel Diseases: Lights and Shadows

Alfarone

Buono

Craviotto

et al. 2022

JCM

Self Cite

View full text Add to dashboard Cite

International guidelines recommend a treat-to-target strategy with a close monitoring of disease activity and therapeutic response in inflammatory bowel diseases (IBD). Colonoscopy (CS) represents the current first-line procedure for evaluating disease activity in IBD. However, as it is expensive, invasive and poorly accepted by patients, CS is not appropriate for frequent and repetitive reassessments of disease activity. Recently, cross-sectional imaging techniques have been increasingly shown as reliable tools for assessing IBD activity. While computed tomography (CT) is hampered by radiation risks, routine implementation of magnetic resonance enterography (MRE) for close monitoring is limited by its costs, low availability and long examination time. Novel magnetic resonance imaging (MRI)-based techniques, such as diffusion-weighted imaging (DWI), can overcome some of these weaknesses and have been shown as valuable options for IBD monitoring. Bowel ultrasound (BUS) is a noninvasive, highly available, cheap, and well accepted procedure that has been demonstrated to be as accurate as CS and MRE for assessing and monitoring disease activity in IBD. Furthermore, as BUS can be quickly performed at the point-of-care, it allows for real-time clinical decision making. This review summarizes the current evidence on the use of cross-sectional imaging techniques as cost-effective, noninvasive and reliable alternatives to CS for monitoring patients with IBD.

show abstract

Assessing Active Bowel Inflammation in Crohn's Disease Using Intestinal Ultrasound

You

Moon

Lee

et al. 2023

J of Ultrasound Medicine

View full text Add to dashboard Cite

AimTo analyze the correlation between intestinal ultrasound (IUS) and serum and fecal biomarkers, and the characteristics of small bowel disease, for the assessment of active bowel inflammation.MethodsPatients with Crohn's disease (CD) who underwent an initial IUS examination between July 2018 and November 2022 at our institution were included retrospectively. We divided small and large bowels into seven segments, and recorded the presence of active inflammation according to following criteria: bowel wall thickness ≥ mm with ≥1 of feature of active disease on IUS. The correlations between IUS‐assessed activity and serum C‐reactive protein (CRP, mg/dL) and fecal calprotectin (FC, μg/g) levels were analyzed.ResultsA total of 127 patients were included (mean age: 32.42 ± 12.07, M:F = 90:37, median disease duration 6 years [0–35]). Of them, 78 showed active bowel inflammation (61.4%), with inflammation distal to the terminal ileum being the most common disease location (n = 61, 78.2%). FC and serum CRP levels were significantly correlated with the number of segments with active inflammation (rho = 0.58, 0.48), number of segments with complications (r = 0.35, 0.31), and US activity score (r = 0.62, 0.54). With FC cutoff values of 100 and 150 μg/g, the concordance rates for patients with active small bowel disease were 78.7% (26/33) and 72.7% (24/33), respectively, which were better than those for other disease locations.ConclusionsDisease activity determined by IUS was significantly correlated with the biomarkers, with a better concordance rate in patients with active small bowel disease than in those with other disease locations with FC cut‐off values of 100 and 150 μg/g.

show abstract

Predictive Value of Bowel Ultrasound in Crohn’s Disease: A 12-Month Prospective Study

Cited by 36 publications

References 29 publications

Editorial: an accurate, reliable and responsive ultrasound activity score for Crohn’s disease? Sounds good to US. Authors' reply

Editorial: an accurate, reliable and responsive ultrasound activity score for Crohn’s disease? Sounds good to US. Authors' reply

Cross-Sectional Imaging Instead of Colonoscopy in Inflammatory Bowel Diseases: Lights and Shadows

Assessing Active Bowel Inflammation in Crohn's Disease Using Intestinal Ultrasound

Contact Info

Product

Resources

About