Predictive value of blood pressure variability for organ dysfunction in patients with sepsis

Abstract

Background: Sepsis is a common disease in the intensive care unit, accompanied by many complications and high mortality. Organ dysfunction is a major risk factor for death in patients with sepsis. Analyzing the related factors of organ dysfunction caused by sepsis can provide more clinical prevention and treatment targets, and better predict patients' prognoses. This study aimed to investigate the relationship between blood pressure variability (BPV) and organ dysfunction in patients with sepsis. Methods: One hundred and two patients with sepsis treated in our hospital from January 2019 to January 2021 were retrospectively collected as an observation group, and 102 healthy people were collected as a control group. The 24-hour systolic blood pressure variability (24h SBPV) and 24-hour diastolic blood pressure variability (24h DBPV) of the two groups were compared, and the correlation between 24h SBPV, 24h DBPV, and organ function damage to sepsis patients were analyzed. Results: Compared with the control group, the 24h DBPV in the observation group was significantly higher (0.56±0.16 vs. 0.37±0.16, P=0.000). 24h SBPV increased significantly (0.56±0.16 vs. 0.36±0.17, P=0.000). Pearson linear correlation analysis showed 24h SBPV was positively correlated with the level of procalcitonin, APACHEII score, and SOFA score (r=0.301, 0.216 and 0.218, P<0.05). 24h DBPV was positively correlated with the level of procalcitonin, APACHEII score, and SOFA score (r=0.302, 0.212 and 0.210, P<0.05). 24h SBPV and 24h DBPV are of certain value in the diagnosis of multiple organ failure in patients with sepsis, and the area under the curve was [0.649 (95% CI: 0.539-0.759), P=0.010] and [0.650 (0.540-0.760), P=0.009], respectively. 24h SBPV and 24h DBPV are of certain value in the diagnosis of persistent organ failure in patients with sepsis, and the area under the curve was [0.647 (95% CI: 0.538-0.757), P=0.010] and [0.647 (95% CI: 0.538-0.757), P=0.010], respectively. Conclusions:The increase of BPV in patients with sepsis has a certain value in predicting the prognosis and organ function damage to patients with sepsis.

Influence of ambulatory blood pressure-related indicators within 24 h on in-hospital death in sepsis patients

“…Most previous studies have focused on the effects of blood pressure and its variability in patients with hypertension or in healthy people on the heart, brain, and other organs, with few studies investigating the effects of blood pressure and its variability on prognosis in sepsis patients 31 , 32 . To our knowledge, the present study is the first to analyze a large critical-illness database in order to identify the predictive value of indicators of the ambulatory blood pressure on in-hospital death in sepsis patients.…”

Incidence of Sepsis Risk Factors in Hopsital Research using Vosviewer: A Bibliometrics Study

“…These conditions can cause organ dysfunction, circulatory disorders, and high mortality. Severe organ dysfunction caused by sepsis is a significant cause of death (Zhu et al, 2021). By analyzing the factors associated with sepsis organ function injury can provide more clinical prevention and targets of sepsis-related organ function injuries and predict the patient's prognosis (Rogne et al, 2021).…”