Predictive value of blood measurement of Complement System proteins and metabolic components for early detection of obstetric complications linked to poor placental function

Correa, N Toledo; Arbildi, Paula; Rosano, Sebastián; López, Valentina; Rodríguez-Camejo, Claudio; Colistro, Valentina; Zubiaurre, Valentina; Cora, Mariana; Sosa, Leonardo; Hernández, Ana; Sóñora, Cecilia

doi:10.1016/j.placenta.2020.09.005

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Pregnancy outcomes, ranging from pre‐eclampsia to SGA deliveries, were significantly higher in pregnancies initiated in women with risk factors. While no changes in AP‐specific proteins (Bb, FD) were observed, elevated CRP, C4, and C3a were seen in the at risk group, implying CP and/or LP activation 141 . It has been suggested that higher CRP levels may have an impact on the regulatory activity of FH, impairing its ability to clear apoptotic cells 101 .…”

Section: Pregnancy Disordersmentioning

confidence: 98%

“…Correa et al compared immunological and metabolic blood components during the first half of pregnancy in women who began a pregnancy under normal healthy conditions with those who had risk factors for obstetric complications, including obesity 141 . Pregnancy outcomes, ranging from pre‐eclampsia to SGA deliveries, were significantly higher in pregnancies initiated in women with risk factors.…”

Section: Pregnancy Disordersmentioning

confidence: 99%

“…While no changes in AP‐specific proteins (Bb, FD) were observed, elevated CRP, C4, and C3a were seen in the at risk group, implying CP and/or LP activation. 141 It has been suggested that higher CRP levels may have an impact on the regulatory activity of FH, impairing its ability to clear apoptotic cells. 101 CRP binds to FH SCRs 7 and 8–11 in a calcium dependent manner.…”

Section: Pregnancy Disordersmentioning

confidence: 99%

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Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events

Smith-Jackson

Harrison

2022

Immunological Reviews

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During pregnancy, the maternal host must adapt in order to enable growth of the fetus.These changes affect all organ systems and are designed both to protect the fetus and to minimize risk to the mother. One of the most prominent adaptations involves the immune system. The semi-allogenic fetoplacental unit has non-self components and must be protected against attack from the host. This requires both attenuation of adaptive immunity and protection from innate immune defense mechanisms. One of the key innate immune players is complement, and it is important that the fetoplacental unit is not identified as non-self and subjected to complement attack. Adaptation of the complement response must, however, be managed in such a way that maternal protection against infection is not compromised. As the complement system also plays a significant facilitating role in many of the stages of a normal pregnancy, it is also important that any necessary adaptation to accommodate the semi-allogenic aspects of the fetoplacental unit does not compromise this. In this review, both the physiological role of the alternative pathway of complement in facilitating a normal pregnancy, and its detrimental participation in pregnancy-specific disorders, are discussed.

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Section: Pregnancy Disordersmentioning

confidence: 98%

Section: Pregnancy Disordersmentioning

confidence: 99%

Section: Pregnancy Disordersmentioning

confidence: 99%

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Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events

Smith-Jackson

Harrison

2022

Immunological Reviews

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“…Immunoassays allow to obtain information about the functioning of the vertebrate immune system in health and disease [15], [39], [64] , [18], [47], [52], [65], [61], [67][68], [42] , but as well are useful tools in diverse fields, for example, environmental control [53], [48], [55], [58], [63], [56]. Synthetic polymers have several applications there since most of the immunoassays make use of the interactions of proteins or peptides with synthetic polymers [40, 43, 45, 46] [57,68]; [49] [59-60][41][62][53].…”

Section: 3) Uses In the Development Of Immunoassaysmentioning

confidence: 99%

Identification and Pharmacognostic Control of the Species: Mentha X Villosa, Lippia Alba, Cymbopogon Citratus and Melissa Officinalis

Camargo¹,

Caetano²,

Camargo³

2023

Ciências Exatas E Suas Tecnologias

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A presente obra demonstra como o avanço tecnológico impactou a área de Ciências Exatas, fazendo com que os seus profissionais, presentes em inúmeros setores, utilizassem os recursos disponíveis como aliados no desenvolvimento de suas atividades. Dentro deste contexto, apresentamos dezoito capítulos voltados ao estudo e à análise do avanço da tecnologia no campo das diversas profissões por elas abarcadas, bem como as vantagens de investir em recursos tecnológicos que se apresentem precisos, minimizando eventuais desperdícios, falhas, culminando, outrossim, em uma maior organização e produtividade, reconhecendo a necessidade da existência de profissionais devidamente qualificados, que se amoldem aos novos padrões apresentados pelo mercado de trabalho. A partir da leitura dos capítulos, verificar-se-á a multidisciplinariedade da ciência e tecnologia e, ainda, auxiliará a compreensão dos fundamentos para que possa ocorrer seu desenvolvimento de forma aliada aos processos manuais já existentes em nossa sociedade. Boa leitura.

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Combined Oral Contraceptive Pill-Induced Hypertension and Hypertensive Disorders of Pregnancy: Shared Mechanisms and Clinical Similarities

2021

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Predictive value of blood measurement of Complement System proteins and metabolic components for early detection of obstetric complications linked to poor placental function

Cited by 6 publications

References 22 publications

Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events

Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events

Identification and Pharmacognostic Control of the Species: Mentha X Villosa, Lippia Alba, Cymbopogon Citratus and Melissa Officinalis

Combined Oral Contraceptive Pill-Induced Hypertension and Hypertensive Disorders of Pregnancy: Shared Mechanisms and Clinical Similarities

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