Predictive value of B-type natriuretic peptide for postoperative atrial fibrillation following pulmonary resection for lung cancer

Abstract

Preoperative BNP level seems to be an appropriate predictor of AF after pulmonary resection.

Fluid and electrolyte balance after major thoracic surgery by bioimpedance and endocrine evaluation

“…The overall BNP pattern appears somewhat biphasic. This is consistent with findings by Nojiri et al [22] in a study designed to evaluate the association between BNP secretion and postoperative atrial fibrillation. They reported a biphasic BNP pattern in a series of 80 patients with lung cancer submitted to pulmonary resection (not pneumonectomy).…”

“…Its association with heart failure, atrial fibrillation [22,23] and other cardiac or infective complications following pulmonary resection [24] is well documented. Elevated BNP levels are associated with primary pulmonary hypertension and this marker can distinguish heart failure from other causes of dyspnoea more accurately than left-ventricular (LV) ejection fraction and ANP level [10].…”

“…They reported a biphasic BNP pattern in a series of 80 patients with lung cancer submitted to pulmonary resection (not pneumonectomy). They explained the early peak to be caused by an increase of right-ventricular (RV) overload, with a decreased volume of the pulmonary vascular bed caused by pulmonary resection, and the late peak, due to RV and LV overloading caused by a change in the circulating fluid balance or the so-called refilling phenomenon [22].…”

Prevention of Atrial Fibrillation in High-risk Patients Undergoing Lung Cancer Surgery

“…11 Thus far, an accumulating body of published data has illustrated that increased levels of natriuretic peptides predict postoperative major adverse clinical events, in general, and specifically PAF, both in cardiac and noncardiac surgery. 5,13,14,[46][47][48][49][50] The mechanisms underlying the link between high NT-proBNP values and increased PAF risk remain unclear. Natriuretic peptides may increase with chronic conditions that include aging, atrial fibrosis, and inflammation-factors also known to contribute to PAF occurrence.…”

Safety of Landiolol Infusion in Patients Undergoing Lung Resection

“…There are however conflicting reports about the reduction in postsurgical complications due to VATS [16] [17] [18], as well as other reports about reduction of postoperative AF thanks to thoracic epidural anesthesia in the setting of cardiovascular surgery. Further research on these issues is needed, and such studies may benefit by incorporating preoperative atrial natriuretic peptide and B-type natriuretic peptide, which Nojiri et al [19] reported could be a predictive factor for the occurrence of postoperative AF.…”