Predictive V16alue of Thymidylate Synthase Expression in Gastric Cancer: A Systematic Review with Meta-analysis

Hu, Huabin; Kuang, Lei; Zeng, Xiaomin; B, Li; Liu, Enyi; Zhong, Meizuo

doi:10.7314/apjcp.2012.13.1.261

Cited by 15 publications

(13 citation statements)

References 40 publications

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“…Our results are consistent with a treatment effect that has been reported by Hu et al . [25]. Shorter survival in the V-325 study group may be due to the inclusion of more patients with liver metastases and fewer stage III patients.…”

Section: Discussionmentioning

confidence: 99%

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RETRACTED ARTICLE: Joint detection of ERCC1, TUBB3, and TYMS guidance selection of docetaxel, 5-fluorouracil and cisplatin (DDP) individual chemotherapy in advanced gastric cancer patients

Luo

Cui

et al. 2014

Eur J Med Res

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BackgroundTo investigate the guidance selection of docetaxel (D), cisplatin (DDP) (C), and 5-fluorouracil (5-FU) (F) as individual chemotherapy agents via joint detection of ERCC1, TUBB3, and TYMS genes in patients with advanced gastric cancer (AGC).MethodClinical data of 120 patients with AGC who enrolled in our hospital between May 2009 and May 2012 were analyzed. These patients were randomly assigned to experimental and control groups. The mRNA expression of ERCC1, TUBB3, and TYMS was measured by DNA chip technology in the experimental group. Different chemotherapies were administered according to the mRNA expression levels of the three genes, while DCF chemotherapy was directly applied to the control group. Correlation between the three genes’ mRNA levels, efficiency rate, the median time to progression (MTP), median survival time (MST) and adverse reactions was evaluated.ResultsAs a result, there was a significant correlation between ERCC1 and TUBB3 mRNA expression (P = 0.005), but no obvious correlation between TUBB3 and TYMS or ERCC1 and TYMS. There was also no significant difference in the efficiency rate of chemotherapy (50% versus 55%; P = 0.357) and the MTP (10 months versus 7 months; P = 0.091) between the two groups. However, there was obvious significance in MST (13.7 months versus 11.6 months; P = 0.004). Additionally, the experimental group provided us with a more effective way for controlling adverse reactions to chemotherapy.ConclusionCombination regimen of D, C, and F in AGC patients according to their ERCC1, TUBB3, and TYMS mRNA expression level may reduce adverse reactions and improve MST.

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Section: Discussionmentioning

confidence: 99%

“…Through meta-analysis, Hu et al . [25] have pointed out that TYMS is one of the useful predictive and prognostic genetic factors.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Joint detection of ERCC1, TUBB3, and TYMS guidance selection of docetaxel, 5-fluorouracil and cisplatin (DDP) individual chemotherapy in advanced gastric cancer patients

Luo

Cui

et al. 2014

Eur J Med Res

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“…If TS expression is low in tumor tissue or its catalytic activity is inhibited, DNA replication and cell proliferation may be inhibited. High TS expression level is related to poor outcome in several types of cancer [47][48][49][50][51][52][53]. Both pemetrexed and 5-FU are TS inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Prognostic and predictive significance of thymidylate synthase protein expression in non-small cell lung cancer: A systematic review and meta-analysis

Liu

Xiang

et al. 2015

CBM

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“…It is a target for major chemotherapeutic drugs, and its expression is associated with tumour aggressiveness and poor prognosis [20]. In patients with advanced gastric cancer, TS has been identified as a prognostic marker, and high TS expression is associated with worse overall survival [21]. Several polymorphisms in the TS UTRs, which may influence TS mRNA transcription, message stability or protein expression, have been identified [22].…”

Section: Introductionmentioning

confidence: 99%

Association between polymorphisms of thymidylate synthase gene 5′- and 3′-UTR and gastric cancer risk: meta-analysis

Zhao

Shi

et al. 2016

Bioscience Reports

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Gastric cancer is the most common cancer and the most frequent cause of cancer death worldwide. Several studies have identified the role of thymidylate synthase (TS) 5′- and 3′-UTR and gastric cancer susceptibility; however, the results still remain inconclusive. The purpose of this meta-analysis was to reinvestigate this correlation. In the present study, online databases were searched to retrieve relevant articles published between January 2000 and 2016. The odds ratio (OR) and 95% confidence interval (CI) were employed to calculate the strength of association. Overall, a total of 13 articles were screened out, including 2382 gastric cancer patients and 3171 healthy controls. We found that polymorphisms of TS 5′-UTR 2R (double repeats)/3R (triple repeats) of a 28-bp sequence (11 articles) and 3′-UTR del6/ins6 (seven articles) were not significantly associated with increased risk of gastric cancer. Subgroup analysis by ethnicity showed that 2R allele and 2R/2R genotype in TS 5′-UTR were associated with gastric cancer susceptibility in Caucasian and African populations; del6 allele, del6/del6 and del6/ins6 genotypes were correlated with gastric cancer in Caucasian population. In conclusion, our result suggested that TS polymorphisms might be the risk factors for gastric cancer risk in Caucasian population, although this association needs further study, and future large-scale researches are still required.

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Predictive V16alue of Thymidylate Synthase Expression in Gastric Cancer: A Systematic Review with Meta-analysis

Cited by 15 publications

References 40 publications

RETRACTED ARTICLE: Joint detection of ERCC1, TUBB3, and TYMS guidance selection of docetaxel, 5-fluorouracil and cisplatin (DDP) individual chemotherapy in advanced gastric cancer patients

RETRACTED ARTICLE: Joint detection of ERCC1, TUBB3, and TYMS guidance selection of docetaxel, 5-fluorouracil and cisplatin (DDP) individual chemotherapy in advanced gastric cancer patients

Prognostic and predictive significance of thymidylate synthase protein expression in non-small cell lung cancer: A systematic review and meta-analysis

Association between polymorphisms of thymidylate synthase gene 5′- and 3′-UTR and gastric cancer risk: meta-analysis

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