Predictive Significance of Magnetic Resonance Imaging at 4 Months of Adjusted Age in Infants after a Perinatal Neurologic Insult

Millet, V.; Bartoli, Jean Michel; Lacroze, V.; Raybaud, Charles; D, Unal; Girard, Nadine

doi:10.1159/000013979

Cited by 13 publications

(11 citation statements)

References 40 publications

(40 reference statements)

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“…Although rare, MRI beyond the first month after birth is sometimes performed to assess myelination and the evolution of lesions that were seen on the neonatal scan, or when infants were too ill to be scanned within the first weeks after birth [101]. There are studies that have suggested that MRI performed at 2-5 months of age has a predictive significance for later neurodevelopmental outcomes, but literature on MRI at this age is scarce [101][102][103].…”

Section: Repeat Mrimentioning

confidence: 99%

Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy

2022

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Hypoxic-ischemic encephalopathy (HIE) is a major cause of neurological sequelae in (near-)term newborns. Despite the use of therapeutic hypothermia, a significant number of newborns still experience impaired neurodevelopment. Neuroimaging is the standard of care in infants with HIE to determine the timing and nature of the injury, guide further treatment decisions, and predict neurodevelopmental outcomes. Cranial ultrasonography is a helpful noninvasive tool to assess the brain before initiation of hypothermia to look for abnormalities suggestive of HIE mimics or antenatal onset of injury. Magnetic resonance imaging (MRI) which includes diffusion-weighted imaging has, however, become the gold standard to assess brain injury in infants with HIE, and has an excellent prognostic utility. Magnetic resonance spectroscopy provides complementary metabolic information and has also been shown to be a reliable prognostic biomarker. Advanced imaging modalities, including diffusion tensor imaging and arterial spin labeling, are increasingly being used to gain further information about the etiology and prognosis of brain injury. Over the past decades, tremendous progress has been made in the field of neonatal neuroimaging. In this review, the main brain injury patterns of infants with HIE, the application of conventional and advanced MRI techniques in these newborns, and HIE mimics, will be described.

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Section: Repeat Mrimentioning

confidence: 99%

Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy

2022

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“…Cerebral palsy in pre-term infants was predicted by altered MRI signals associated with hemorrhagic and white matter lesions. In term infants, T2-signal abnormalities, more then T1 abnormalities, predicted an unfavorable outcome, documenting poor myelination and focal/multifocal lesions on subsequent studies for children with subsequent neurologic insults [78].…”

Section: Neuroimagingmentioning

confidence: 93%

Perinatal asphyxia: Timing and mechanisms of injury in neonatal encephalopathy

Scher

2001

Curr Neurol Neurosci Rep

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This article summarizes the recent medical literature regarding perinatal asphyxia with respect to timing and mechanisms of injury for neonates who were clinically diagnosed with an encephalopathy in the newborn period. Multiple mechanisms of injury are reviewed, including genetic vulnerability, acquired inflammatory responses, and clotting defects that can lead to ischemic-induced brain damage. Before effective treatments for fetal and neonatal brain disorders can be developed, accurate and timely diagnoses of fetal or neonatal brain injury must be achieved. Specific subsets of children can then benefit from neuroprotective strategies that can target the specific developmental aspects of brain adaptation or plasticity relative to the specific etiology and timing of injury after asphyxia.

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“…Most studies included only infants with gestational age ≥36.0 weeks (n = 8, 67%). In three studies, only a subset of the study population had a history of perinatal asphyxia [16][17][18]. Age at last follow-up assessment ranged from 3 months to 17 years of age.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Most studies used the Griffiths Mental Development Scales (n = 4) and/or different editions of the Denver Developmental Screening Test (n = 4) and the Bayley Scales of Infant and Toddler Development (n = 3) to assess neurodevelopmental outcomes. All twelve studies analyzed infants with a later MRI performed within 18 months after birth [10,[16][17][18][19][20][21][22][23][24][25][26] and three studies also described a subset of infants with MRI performed at 18-24 months after birth [10,16,24]. For six papers, the data as presented by the study were re-analyzed in SPSS, as a complete statistical analysis was not provided in the article.…”

Section: Study Characteristicsmentioning

confidence: 99%

Cranial MRI beyond the Neonatal Period and Neurodevelopmental Outcomes in Neonatal Encephalopathy Due to Perinatal Asphyxia: A Systematic Review

Parmentier,

Kropman,

Groenendaal

et al. 2023

JCM

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Background: Magnetic resonance imaging (MRI) including diffusion-weighted imaging within seven days after birth is widely used to obtain prognostic information in neonatal encephalopathy (NE) following perinatal asphyxia. Later MRI could be useful for infants without a neonatal MRI or in the case of clinical concerns during follow-up. Therefore, this review evaluates the association between cranial MRI beyond the neonatal period and neurodevelopmental outcomes following NE. Methods: A systematic literature search was performed using PubMed and Embase on cranial MRI between 2 and 24 months after birth and neurodevelopmental outcomes following NE due to perinatal asphyxia. Two independent researchers performed the study selection and risk of bias analysis. Results were separately described for MRI before and after 18 months. Results: Twelve studies were included (high-quality n = 2, moderate-quality n = 6, low-quality n = 4). All reported on MRI at 2–18 months: seven studies demonstrated a significant association between the pattern and/or severity of injury and overall neurodevelopmental outcomes and three showed a significant association with motor outcome. There were insufficient data on non-motor outcomes and the association between MRI at 18–24 months and neurodevelopmental outcomes. Conclusions: Cranial MRI performed between 2 and 18 months after birth is associated with neurodevelopmental outcomes in NE following perinatal asphyxia. However, more data on the association with non-motor outcomes are needed.

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Predictive Significance of Magnetic Resonance Imaging at 4 Months of Adjusted Age in Infants after a Perinatal Neurologic Insult

Cited by 13 publications

References 40 publications

Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy

Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy

Perinatal asphyxia: Timing and mechanisms of injury in neonatal encephalopathy

Cranial MRI beyond the Neonatal Period and Neurodevelopmental Outcomes in Neonatal Encephalopathy Due to Perinatal Asphyxia: A Systematic Review

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