Predictive significance of glomerular insulin receptor substrate-1 in patients with diabetic kidney disease

Mima, Akira; Murakami, Ami; Lee, Rina; Lee, Shinji

doi:10.1016/j.metop.2023.100240

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…However, the cell type expressing the receptor in both cases were the endothelial cells. Previous studies have corroborated the decreased INSR expression in kidney diseases [ 81 , 82 ], while others have validated the increase of the receptor in liver diseases, highlighting the involvement of stellate cells in the process [ 83 ]. In addition, research has pinpointed the association between NAMPT in obesity and diabetes [ 84 – 87 ], as well as its function in MASH [ 88 , 89 ], which highlights one more time the complex mechanisms within these metabolic diseases.…”

Section: Discussionmentioning

confidence: 90%

Identification of ligand and receptor interactions in CKD and MASH through the integration of single cell and spatial transcriptomics

Moreno,

Gluud,

Galsgaard

et al. 2024

PLoS ONE

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Background Chronic Kidney Disease (CKD) and Metabolic dysfunction-associated steatohepatitis (MASH) are metabolic fibroinflammatory diseases. Combining single-cell (scRNAseq) and spatial transcriptomics (ST) could give unprecedented molecular disease understanding at single-cell resolution. A more comprehensive analysis of the cell-specific ligand-receptor (L-R) interactions could provide pivotal information about signaling pathways in CKD and MASH. To achieve this, we created an integrative analysis framework in CKD and MASH from two available human cohorts. Results The analytical framework identified L-R pairs involved in cellular crosstalk in CKD and MASH. Interactions between cell types identified using scRNAseq data were validated by checking the spatial co-presence using the ST data and the co-expression of the communicating targets. Multiple L-R protein pairs identified are known key players in CKD and MASH, while others are novel potential targets previously observed only in animal models. Conclusion Our study highlights the importance of integrating different modalities of transcriptomic data for a better understanding of the molecular mechanisms. The combination of single-cell resolution from scRNAseq data, combined with tissue slide investigations and visualization of cell-cell interactions obtained through ST, paves the way for the identification of future potential therapeutic targets and developing effective therapies.

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Section: Discussionmentioning

confidence: 90%

Identification of ligand and receptor interactions in CKD and MASH through the integration of single cell and spatial transcriptomics

Moreno,

Gluud,

Galsgaard

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…UPCR was calculated by dividing the level of protein (mg/dL) in a spot urine test by the creatine level (mg/dL). The eGFR of each patient was calculated using the formula by isotope dilution mass spectrometry (IDMS) traceable 4-variable MDRD (Modification of Diet in Renal Disease) (IDMS-MDRD Study formula) with the 3-variable Japanese equation: 194 × serum creatinine - 1.094 × age - 0.287 × 0.739 (if female) [ [15] , [16] , [17] , [18] ].…”

Section: Methodsmentioning

confidence: 99%

Effect of finerenone on diabetic kidney disease outcomes with estimated glomerular filtration rate below 25 mL/min/1.73 m2

Mima,

Lee,

Murakami

et al. 2023

Metabolism Open

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“…Retrospective data collection or information from electronic medical records of Osaka Medical and Pharmaceutical University included data from biochemical analysis conducted using a Labospect 008 autoanalyzer (Hitachi Ltd., Tokyo, Japan). The extracted data encompassed details such as serum UA, triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, serum creatinine, urine proteinto-creatinine ratio (UPCR), and patient characteristics, including age, sex, medication, blood pressure, and BMI [12][13][14]. The eGFR for each patient was determined using the isotope dilution mass spectrometry (IDMS) traceable 4-variable Modification of Diet in Renal Disease (MDRD) formula, incorporating the 3-variable Japanese equation: 194 × serum creatinine -1.094 × age -0.287 × 0.739 (if female) [14][15][16][17].…”

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confidence: 99%

Safety and Efficacy of Dotinurad on Uric Acid in Patients With Chronic Kidney Disease With Estimated Glomerular Filtration Rate Below 25 mL/Min/1.73 m²

Mima,

Gotoda,

Lee

2024

Cureus

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Introduction Dotinurad is being developed as a selective uric acid reabsorption inhibitor. However, its effect on lowering serum uric acid (UA) levels in chronic kidney disease (CKD) patients with severe renal dysfunction is unknown. Therefore, the purpose of this study was to determine the effect of dotinurad on renal function in CKD patients with an estimated glomerular filtration rate (eGFR) below 25 mL/min/1.73 m 2 . Methods Seven patients with CKD who received dotinurad 0.5 mg to 4 mg per day were studied retrospectively. Changes in UA, eGFR, and urine protein-to-creatinine ratio (UPCR) were analyzed. The observation period was 10.9±2.1 months. Results Serum UA levels were decreased and maintained with dotinurad administration. Nevertheless, there were no improvements noted in renal function. Additionally, no serious adverse effects were identified in any of the patients throughout the observation period. Conclusion Although the sample size in this study was small, our findings demonstrate the efficacy of dotinurad in individuals with advanced CKD who have an eGFR lower than 25 mL/min/1.73 m 2 .

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Predictive significance of glomerular insulin receptor substrate-1 in patients with diabetic kidney disease

Cited by 5 publications

References 33 publications

Identification of ligand and receptor interactions in CKD and MASH through the integration of single cell and spatial transcriptomics

Identification of ligand and receptor interactions in CKD and MASH through the integration of single cell and spatial transcriptomics

Effect of finerenone on diabetic kidney disease outcomes with estimated glomerular filtration rate below 25 mL/min/1.73 m2

Safety and Efficacy of Dotinurad on Uric Acid in Patients With Chronic Kidney Disease With Estimated Glomerular Filtration Rate Below 25 mL/Min/1.73 m²

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