Predictive role of toll-like receptors 2, 4, and 9 in oral tongue squamous cell carcinoma

Mäkinen, Laura K.; Atula, Timo; Häyry, Valtteri; Jouhi, Lauri; Datta, Neeta; Lehtonen, Sanna; Ahmed, Abdirisak; Mäkitie, Antti; Haglund, Caj; Hagström, Jaana

doi:10.1016/j.oraloncology.2014.08.017

Cited by 42 publications

(95 citation statements)

References 27 publications

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“…Similar results were obtained in separate immunohistochemical studies conducted by Szczepanski et al (Szczepanski et al, 2009) on head and neck cancers and on oral cancer, in which a strong positive reaction for TLR4 was characteristic for well-differentiated or moderately differentiated tumors relative to moderate or weak staining intensity in poorly differentiated tumors (Nair et al, 2013). TLR4 has been associated also with the invasive potential of early-stage OTSCC (Makinen et al, 2015).…”

Section: Tablesupporting

confidence: 79%

“…Furthermore, another study demonstrated that the pattern of expression of TLR4 and TLR9 increased significantly from mild to severe oral epithelial dysplasia (OED), reflecting the progression of OED in oral squamous cell carcinoma . Also, a high/strong expression of TLR2, TLR4, and TLR9 seems to predict an invasive tumor growth of oral tongue squamous cell carcinoma (OTSCC) (Makinen et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Differential expression of TLR3 and TLR4 in keratocystic odontogenic tumor (KCOT): A comparative immunohistochemical study in primary, recurrent, and nevoid basal cell carcinoma syndrome (NBCCS)–associated lesions

Leonardi

Perrotta

Crimi

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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Section: Tablesupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Differential expression of TLR3 and TLR4 in keratocystic odontogenic tumor (KCOT): A comparative immunohistochemical study in primary, recurrent, and nevoid basal cell carcinoma syndrome (NBCCS)–associated lesions

Leonardi

Perrotta

Crimi

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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“…The significance of cancer expressed TLR4 in cancer-related inflammation has also been outlined. TLR4 overexpression has been detected in various tumor cell lines and could predict the tumor growth or recurrence in gastric tumors, oral tongue squamous cell carcinoma and prostate cancer recurrence (7, 8, 32). For lung cancer, previous research showed that TLR4 were more strongly expressed in lung cancer tissue than para-cancer tissue and was positively correlated with the differentiation degree of tumor cells (10, 11).…”

Section: Discussionmentioning

confidence: 99%

“…Except for immune cells, endothelial and various cancer cells also express TLR4, and chronic stimulation of TLR4 could promote tumor initiation, growth, and tumor immune escape and induce chemoresistance through pro-inflammatory responses and antiapoptotic signals. Consequently, the inverse correlation of cancer expressed TLR4, and patients’ outcome has been reported (7, 8). …”

Section: Introductionmentioning

confidence: 99%

Expression of TLR4 in Non-Small Cell Lung Cancer Is Associated with PD-L1 and Poor Prognosis in Patients Receiving Pulmonectomy

Wang

Wei

et al. 2017

Front. Immunol.

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Currently, the effect of inflammation on tumorigenesis and progression has been widely noted. As a member of pattern recognition receptors, toll-like receptor 4 (TLR4) plays a pivotal role in tumor immune microenvironment and has been increasingly investigated. In the present study, we evaluated TLR4 expression and its association with programmed cell death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC) tissues and assessed the predicting value of TLR4 on postoperative outcome. A total of 126 NSCLC patients receiving complete pulmonary resection and systematic lymph node dissection between April 2008 and August 2014 were enrolled. All the patients had integrated clinicopathological records and follow-up data. TLR4 and PD-L1 expression on NSCLC samples were determined by immunohistochemistry, and serum soluble TLR4 (sTLR4) levels were measured by enzyme-linked immunosorbent assay. Results showed that TLR4 expression level in cancer tissue was significantly higher than that in para-cancer tissue. Elevated TLR4 expression was significantly associated with histological type (adenocarcinoma higher than squamous cell carcinoma, P = 0.041), increased clinical TNM stage (P < 0.001), and presence of lymphatic invasion (P < 0.001). Besides, TLR4 expression level in cancer samples was inversely correlated with serum sTLR4 level in patients with early-stage NSCLC (r = −0.485, P = 0.003). TLR4 expression level was also positively correlated with the PD-L1 expression level (r = 0.545, P < 0.0001). Multivariate analysis showed that expression level of TLR4 was an independent prognostic factor and TLR4 overexpression indicated a poor overall survival and disease-free survival. Taken together, we conclude that expression of TLR4 in lung cancer is associated with PD-L1 and could predict the outcome of patients with NSCLC receiving pulmonary resection for cancer.

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“…Grimm et al found that high expression of TLR8 was an independent prognostic factor for worse outcome in multivariate analysis 14. Makinen et al found that high or strong TLR2 expression was correlated with deeper tumor invasion, whereas negative or mild TLR5 expression predicted poor disease-specific survival 40. Gonzalez-Reyes et al reported that tumors with high TLR3 expression were significantly associated with higher probability of metastasis in BC and with higher probability of biochemical recurrence in ProC 41,42.…”

Section: Discussionmentioning

confidence: 99%

Prognostic role of Toll-like receptors in cancer: a meta-analysis

Wang¹,

Zhang²,

Xiao³

et al. 2018

TCRM

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BackgroundRecent studies have shown that Toll-like receptors (TLRs) may be associated with cancers. The aim of this meta-analysis is to summarize the predicting role of TLRs for survival in patients with a variety of carcinomas.Materials and methodsEligible studies were identified and assessed for quality through multiple search strategies. We collected data from studies investigating the relationship between the expression level of TLRs and survival in cancer patients. Studies were pooled and combined hazard ratios (HRs) of TLRs for survival were analyzed.ResultsA total of 24 studies, including 2,812 patients with various cancers, were identified for the meta-analysis. Importantly, this meta-analysis showed that higher expression levels of TLR4 or TLR7 in tumor tissues could predict poorer survival, with the pooled HR being 1.29 (95% CI: 1.17, 1.42) and 1.71 (95% CI: 1.38, 2.12), respectively. However, higher expression of TLR9 had no significant association with outcome as HR was 0.84 (95% CI: 0.62, 1.115). Heterogeneity existed in TLR4 and TLR9 studies (P-value <0.001) but not in TLR7 studies (P-value >0.05).ConclusionThe expression level of TLR4 or TLR7 in cancerous tissue may have a prognosis value in patients with various cancers.

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Predictive role of toll-like receptors 2, 4, and 9 in oral tongue squamous cell carcinoma

Cited by 42 publications

References 27 publications

Differential expression of TLR3 and TLR4 in keratocystic odontogenic tumor (KCOT): A comparative immunohistochemical study in primary, recurrent, and nevoid basal cell carcinoma syndrome (NBCCS)–associated lesions

Differential expression of TLR3 and TLR4 in keratocystic odontogenic tumor (KCOT): A comparative immunohistochemical study in primary, recurrent, and nevoid basal cell carcinoma syndrome (NBCCS)–associated lesions

Expression of TLR4 in Non-Small Cell Lung Cancer Is Associated with PD-L1 and Poor Prognosis in Patients Receiving Pulmonectomy

Prognostic role of Toll-like receptors in cancer: a meta-analysis

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