Predictive role of FAR ratio in Covid-19 patients

Abstract

Objective: No effective treatment has yet been found for SARS-cov-2, which caused a pandemic outbreak in 2019. It is crucial to detect the progression of Covid-19 in patients as early as possible. Fibrinogen to albumin ratio (FAR) has been used as a new inflammatory marker. We aimed to find out whether the use of the FAR ratio as a predictor of mortality in Covid-19 patients provides clinical benefit. Materials and Methods: Data from 590 patients with Covid-19 from 15/03/2020 to 15/01/2021 in medicine wards and intensive care units (ICU) were retrospectively analyzed. Demographic data and other laboratory markers were collected from the electronic medical records. Relationship between FAR ratio was investigated between patients in the survivor/non-survivor patients. Findings: The mean FAR levels in patients who were non survivor was 24.44±30.3 (n:272 and 11.29±6.29 (n:275) (p:0.000) in patients survivor COVID-19 infection. In ROC curve for FAR, the threshold FAR that may pose a risk for mortality was determined as 13.84 ((AUC: 0.808(0.771-0.844)); 74.9% Sensitivity, 74.6% Specificity; p:0.000 )). Result: As a result of this study, increased FAR were found to be important markers in determining the mortality levels in Covid-19 patients. What is already known about FAR ratio: The fibrinogen albumin ratio is a value that has been used to determine the prognosis, especially in malignancies. [32] In a recent study 91 Covid-19 patients were analyzed 22 patients with severe disease higher FAR ratio compare to mild disaese [36] What does this article add about FAR ratio in Covid-19 patients: It has been concluded that the FAR ratio, which is used in diseases such as malignancy, hypertension, and coronary syndrome as a marker of disease progression, can be used as a mortality indicator in Covid-19

Prognostic value of novel serum biomarkers, including C‐reactive protein to albumin ratio and fibrinogen to albumin ratio, in COVID‐19 disease: A meta‐analysis

“…Our study found that FAR values on admission are statistically significantly associated with COVID‐19 mortality. Similar results have been arrived upon in previous studies 42 . Yet, there are multiple possible explanations for FAR on admission to be an unreliable indicator of COVID‐19 severity.…”

“…Subsequently, the full texts of 54 potentially eligible articles were reviewed. After exclusions, 23 studies with a total of 7774 participants remained and were ultimately included in the analysis 12–34 . The process of study selection is summarised in Supplementary Figure using the PRISMAflowchart.…”

“…The process of study selection is summarised in Supplementary Figure using the PRISMAflowchart. Sixteen studies reported the association of CAR with COVID‐19 outcomes, 12–27 four studies included FAR, 28–31 and three studies included both CAR and FAR 32–34 . Table 1 outlines the study characteristics of the included articles, while Table 2 summarises the optimal cut‐off, the area under the curve (AUC), sensitivity, and specificity of CAR and FAR for predicting COVID‐19 mortality and severity.…”