Predictive role of blood eosinophils in adult varicella patients

Abstract

The study aimed to explore the relationship between eosinophils and the prognosis of varicella in adults. We retrospectively reviewed the medical records of patients who were hospitalized in The Fifth People's Hospital of Suzhou with a diagnosis of adult varicella during the period between 1 January 2012 and 31 December 2020. Of the 359 patients, 228 (63.51%) had eosinopenia. The proportion of patients with mild type disease was significantly lower in the eosinopenia group than in the noneosinopenia group (50.44% vs. 65.65%, P=0.006). The proportion of the patients with common type disease was significantly higher in the eosinopenia group than in the noneosinopenia group (39.47% vs. 28.24%, P=0.039).The proportion of the patients with severe type disease was higher in the eosinopenia group, although the difference did not reach statistical significance (10.09% vs. 6.11%, P = 0.243).

Cryptococcal Neoformans and Varicella Zoster Meningitis in a Patient With Selective Innate Immunodeficiency: A Case Report

“…Not much is known about innate immune deficiencies that could render one susceptible to VZV. However, a recent study associated NK disorders with severe disseminated VZV infection, which suggests that relative NK deficiency is a potential cause of VZV susceptibility in this patient [ 12 ]. Furthermore, the International Union of Immunological Societies (IUIS) committee on Inborn Errors of Immunity (IUI), which publishes phenotypic classifications of IUI with associated genetic classification, categorized STAT1 gain-of-function mutations in intrinsic and innate immunity with a predisposition to viral and fungal infections and STAT5b mutation with hypereosinophilia [ 15 ].…”

“…VZV can occur in adults with HIV at any CD4 T cell count, but the risk of infection is higher at a CD4 count< 200 cells/uL. Interestingly, eosinopenia has also been associated with a more serious condition, with higher morbidity and slow recovery [ 12 ]. Here, we report a case of C. neoformans and VZV meningitis that likely resulted from low complement and natural killer cell levels and possible eosinopenia due to prednisone use.…”