Predictive power of maternal serum and amniotic fluid CRP and PAPP-A concentrations at the time of genetic amniocentesis for the preterm delivery

Ozer, Kamer; Kavak, Zehra Neşe; Gökaslan, Hüsnü; Elter, Koray; Pekin, Tanju

doi:10.1016/j.ejogrb.2005.02.021

Cited by 24 publications

(19 citation statements)

References 19 publications

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“…Only one study reported prospective data collection design 215 and only seven of the 13 studies included reported consecutive enrolment. 205,206,209,211,214,215,217 Most of the studies had provided adequate test description but blinding was evident in only four studies.…”

Section: Study Characteristics and Qualitymentioning

confidence: 99%

“…205,206,209,211,214,215,217 Most of the studies had provided adequate test description but blinding was evident in only four studies. 205,206,210,211 The methodological quality of the primary studies included is summarised in Figure 37.…”

Section: Study Characteristics and Qualitymentioning

confidence: 99%

“…either amniotic sample from an amniocentesis or blood serum from venepuncture. Two studies reported on CRP measurement in amniotic fluid obtained at mid-trimester gestation among asymptomatic women, 210,215 while the remaining studies used maternal blood plasma serum levels of CRP obtained either at midtrimester gestation for asymptomatic women or at presentation for women who presented with symptoms of threatened preterm labour. The study population ranged from 34 to 506 women, with a median of 69 women.…”

Section: Study Characteristics and Qualitymentioning

confidence: 99%

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Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

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et al. 2009

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For primary prevention, an effective, affordable and safe intervention applied to all mothers without preceding testing is likely to be the most cost-effective approach in asymptomatic women in early pregnancy. For secondary prevention among women at risk of preterm labour in later pregnancy, a management strategy based on the results of testing is likely to be more cost-effective. Implementation of a treat-all strategy with simple interventions, such as fish oils, would be premature for asymptomatic women. Universal provision of high-quality ultrasound machines in labour wards is more strongly indicated for predicting spontaneous preterm birth among symptomatic women than direct management, although staffing issues and the feasibility and acceptability to mothers and health providers of such strategies need to be explored. Further research should include investigations of low-cost and effective tests and treatments to reduce and delay spontaneous preterm birth and reduce the risk of perinatal mortality arising from preterm birth.

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Section: Study Characteristics and Qualitymentioning

confidence: 99%

Section: Study Characteristics and Qualitymentioning

confidence: 99%

Section: Study Characteristics and Qualitymentioning

confidence: 99%

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Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

182

146

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“…12,13 In the largest series to date, PAPP-A data from 34 271 pregnancies obtained between 10 and 14 weeks gestation showed a very strong association between low PAPP-A levels in the first trimester and several adverse outcomes of pregnancy. 14,15 PAPP-A had been identified by mass spectrometry microsequencing as the Insulin Growth Factor (IGF)-dependent Binding Protein (IGFBP)-4-specific protease 16 from human fibroblast-conditioned media. 17 Recently, PAPP-A was demonstrated to be a metzincin superfamily metalloproteinase involved in normal and pathological IGF physiology.…”

Section: Introductionmentioning

confidence: 99%

PAPP-A levels as an early marker of idiopathic preterm birth: a pilot study

et al. 2007

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Objective: To evaluate late PAPP-A levels as predictive of preterm birth in symptomatic women.Study Design: Prospective cohort study of singleton gestations, 23 to 34 weeks, and symptoms of preterm labor. PAPP-A, IGF-I and IGF-III analysis were performed. Primary end point was delivery p7 days. Accuracy and optimally predictive PAPP-A values were based on receiver operator characteristic (ROC) curves.Result: In all, 26 women (51%) delivered p7 days post-admission (Group 1); 25 women (49%) >7 days (Group 2). Group 1 mean PAPP-A ¼ 38 000 vs 55 333 for Group 2 (P<0.04). Group 1 mean gestational age at delivery ¼ 29 weeks vs 37 weeks for Group 2 (P<0.00014). PAPP-A level p30 000 mU l À1 had highest specificity (88%), sensitivity (50%), and positive predictive (81%) and negative predictive (62%) values for delivery p7 days. ROC area under curve ¼ 0.703.Conclusion: PAPP-A levels p30 000 mU l À1 at admission was associated with increased risk for preterm birth p7 days, supporting active management and therapeutic approach in these women.

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“…[205][206][207][208][209][210][211][212][213][214][215][216][217] summarises each study's salient features, stratified according to the population of women tested, i.e. asymptomatic antenatal women and women with symptoms of threatened preterm labour, and the route of testing, i.e.…”

Section: Study Characteristics and Qualitymentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

2010

Clinical Governance: An International Journal

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Predictive power of maternal serum and amniotic fluid CRP and PAPP-A concentrations at the time of genetic amniocentesis for the preterm delivery

Cited by 24 publications

References 19 publications

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

PAPP-A levels as an early marker of idiopathic preterm birth: a pilot study

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

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