Predictive Power of a Body Shape Index for Development of Diabetes, Hypertension, and Dyslipidemia in Japanese Adults: A Retrospective Cohort Study

Abstract

Background/ObjectivesRecently, a body shape index (ABSI) was reported to predict all-cause mortality independently of body mass index (BMI) in Americans. This study aimed to evaluate whether ABSI is applicable to Japanese adults as a predictor for development of diabetes, hypertension, and dyslipidemia.Subjects/MethodsWe evaluated the predictive power of ABSI in a retrospective cohort study using annual health examination data from Chiba City Hall in Japan, for the period 2008 to 2012. Subjects included 37,581 without diabetes, 23,090 without hypertension, and 20,776 without dyslipidemia at baseline who were monitored for disease incidence for 4 years. We examined the associations of standardized ABSI, BMI, and waist circumference (WC) at baseline with disease incidence by logistic regression analyses. Furthermore, we conducted a case-matched study using the propensity score matching method.ResultsElevated BMI, WC, and ABSI increased the risks of diabetes and dyslipidemia [BMI-diabetes: odds ratio (OR) = 1.26, 95% confidence interval (95%CI) = 1.20−1.32; BMI-dyslipidemia: OR = 1.15, 95%CI = 1.12−1.19; WC-diabetes: OR = 1.24, 95%CI = 1.18−1.31; WC-dyslipidemia: OR = 1.15, 95%CI = 1.11−1.19; ABSI-diabetes: OR = 1.06, 95%CI = 1.01−1.11; ABSI-dyslipidemia: OR = 1.04, 95%CI = 1.01−1.07]. Elevated BMI and WC, but not higher ABSI, also increased the risk of hypertension [BMI: OR = 1.32, 95%CI = 1.27−1.37; WC: OR = 1.22, 95%CI = 1.18−1.26; ABSI: OR = 1.00, 95%CI = 0.97−1.02]. Areas under the curve (AUCs) in regression models with ABSI were significantly smaller than in models with BMI or WC for all three diseases. In case-matched subgroups, the power of ABSI was weaker than that of BMI and WC for predicting the incidence of diabetes, hypertension, and dyslipidemia.ConclusionsCompared with BMI or WC, ABSI was not a better predictor of diabetes, hypertension, and dyslipidemia in Japanese adults.

Capacity of a body shape index and body roundness index to identify diabetes mellitus in Han Chinese people in Northeast China: a cross‐sectional study

“…For a person with a given height and weight, ABSI is suitable for reflecting VAT [14]. Excess VAT correlates with lipid and carbohydrate metabolism dysfunction [11], which is involved in the increased risk of diabetes; however, Fujita et al [21] showed that ABSI was not a better predictor of diabetes, hypertension or dyslipidaemia than BMI or waist circumference in Japanese adults. Maessen et al [15] found that ABSI was not a suitable index to identify either CVD or CVD risk factors in Dutch adults.…”

Circulating Betatrophin and Hepatocyte Growth Factor in Type 2 Diabetic Patients: Their Relationship With Disease Prognosis

“…ABSI was significantly associated with the incidence of diabetes and dyslipidemia even after adjustment for BMI, where it is predictively superior to WC after sex-and age-adjustment in Japanese adults [35]. ABSI is a weaker predictor of cardiovascular disease mortality among White Americans [36], cardiovascular disease risk factors among Asians [35] and stroke risk among Spanish European men [37]. In our controls and patients, ABSI correlated negatively with BMI and HGF.…”

“…ABSI predicted all-cause mortality independent of BMI in a large cohort of American adults during an average 4.8-year follow-up [26,31]. ABSI was significantly associated with the incidence of diabetes and dyslipidemia even after adjustment for BMI, where it is predictively superior to WC after sex-and age-adjustment in Japanese adults [35]. ABSI is a weaker predictor of cardiovascular disease mortality among White Americans [36], cardiovascular disease risk factors among Asians [35] and stroke risk among Spanish European men [37].…”

“…2017;7(1): [31][32][33][34][35][36][37][38][39][40][41][42][43] and/or pathogenetic effectors and that plasma insulin and treatment correlates worse disease severity complication score pointing to a defensive IR strategy. Gene polymorphism and/or resistance to physiological inducers could explain these results that mandated our current molecular studies.…”

“…Comparing healthy controls vs. T2DM patients as whole groups and as respective gender and BMI subgroups showed highly significant increases in total cholesterol (P < 0.001 for Betatrophin and HGF in T2DM J Endocrinol Metab. 2017;7(1): [31][32][33][34][35][36][37][38][39][40][41][42][43] all except the two BMI < 25, P < 0.01).…”