Predictive Model of Quality of Life in Patients with Parkinson’s Disease

Abstract

Parkinson’s disease is a chronic, progressive, and disabling neurodegenerative disease which evolves until the end of life and triggers different mood and organic alterations that influence health-related quality of life. The objective of our study was to identify the factors that negatively impact the quality of life of patients with Parkinson’s disease and construct a predictive model of health-related quality of life in these patients. Methods: An analytical, prospective observational study was carried out, including Parkinson’s patients at different stages in the Albacete Health Area. The sample consisted of 155 patients (T0) who were followed up at one (T1) and two years (T2). The instruments used were a purpose-designed data collection questionnaire and the “Parkinson’s Disease Questionnaire” (PDQ-39), with a global index where a higher score indicates a worse quality of life. A multivariate analysis was performed by multiple linear regression at T0. Next, the model’s predictive capacity was evaluated at T1 and T2 using the area under the ROC curve (AUROC). Results: Predictive factors were: sex, living in a residence, using a cane, using a wheelchair, having a Parkinson’s stage of HY > 2, having Alzheimer’s disease or a major neurocognitive disorder, having more than five non-motor symptoms, polypharmacy, and disability greater than 66%. This model showed good predictive capacity at one year and two years of follow-up, with an AUROC of 0.89 (95% CI: 0.83–0.94) and 0.83 (95% CI: 0.76–0.89), respectively. Conclusions: A predictive model constructed with nine variables showed a good discriminative capacity to predict the quality of life of patients with Parkinson’s disease at one and two years of follow-up.

Cognitive and Motor Impairments in Different Motor Subtypes of Parkinson Disease and Patients’ Quality of Life

“…Cognitive impairment causes serious impairment of social functioning, changes in social roles, and deterioration of relationships with family and friends, affecting patients' overall quality of life [16]. At the same time, cognitive decline has been identified as a prognostic factor of quality of life for patients with PD [17].…”

“…Когнітивні порушення спричиняють серйозні порушення соціального функціонування, зміни соціальних ролей, погіршення стосунків з близькими та друзями, що має своє відображення на загальній якості життя пацієнтів [16]. Поряд з цим когнітивне зниження було визначене як прогностичний фактор якості життя для пацієнтів з ХП [17].…”

Integrative Analysis of Predictors for Unfavorable Course of Parkinson Disease According to Medical Care Assessment: Cohort Retrospective Study

“…Эталонной шкалой, определяющей прогрессирование БП, остается шкала Хен и Яра [11,12]. В нашем исследовании в качестве прогрессирующего течения принимались изменения стадий по Хен и Яру на более плохую за период наблюдения.…”

“…Эти данные также согласуются с результатами исследования S. Mantri et al (2019) [14], указывающими на роль деменции в нарушении режима дозирования лекарств, и K. Swarztrauber et al (2006) [17] о роли депрессии в комплаентности с пациентом. Ряд авторов [12,15] указывают на риск полипрагмазии в назначении противопаркинсонических препаратов. В то же время отмечают необходимость своевременного назначения дополнительных препаратов к леводопе при развитии двигательных осложнений [28], что нашло подтверждение и в нашем исследовании.…”

Local Community Policy and The Value of Local Wisdom of The Kemang Plant

“…This disease attacks selected people and occur when that person comes in contact with the Kemang plant [17]. While Parkinson's disease is not the case, the disease comes suddenly because it is influenced by genes and the environment [18]. If this is local to the basil plant, it will have an impact on the value of the basil plant policy so that the plant only grows wild in certain areas that are not accessible to many people [12].…”