Predictive model for atrial fibrillation in hypertensive diabetic patients

Abstract

Background: Several scores to identify patients at high risk of suffering atrial fibrillation have been developed. Their applicability in hypertensive diabetic patients, however, remains uncertain. Our aim is to develop and validate a diagnostic predictive model to calculate the risk of developing atrial fibrillation at five years in a hypertensive diabetic population. Methods: The derivation cohort consisted of patients with both hypertension and diabetes attended in any of the 52 primary healthcare centres of Barcelona; the validation cohort came from the 11 primary healthcare centres of Terres de l'Ebre (Catalonia South) from January 2013 to December 2017. Multivariable Cox regression identified clinical risk factors associated with the development of atrial fibrillation. The overall performance, discrimination and calibration of the model were carried out. Results: The derivation data set comprised 54 575 patients. The atrial fibrillation rate incidence was 15.3 per 1000 person/year. A 5-year predictive model included age, male gender, overweight, heart failure, valvular heart disease, peripheral vascular disease, chronic kidney disease, number of antihypertensive drugs, systolic and How to cite this article:

Blood-biomarkers and devices for atrial fibrillation screening: Lessons learned from the AFRICAT (Atrial Fibrillation Research In CATalonia) study

“…However, the application of a clinical risk model in this group of patients will optimize even more the selection of candidates to screen. Results have been previously published on the possible relationship between the clinical profile and the risk of AF [ 19 ].…”

Effects of Erythrina senegalensis (Fabaceae) Stem Bark Aqueous Extract in Cardiovascular Complications on Hypertensive Diabetic Rat

“…Cardiovascular complications are among the main causes of morbidity and mortality in diabetic hypertension [6]. Strict control of blood glucose and blood pressure has been shown to limit these various complications in diabetic hypertensive patients [8]. The objective of this study was to evaluate the effects of aqueous extract of E. senegalensis on cardiovascular complications in a hypertensive diabetic rat model.…”

“…The accumulation of cholesterol in the heart and the atherogenic index expose the heart and aorta to oxidative damage [29][30]. Normalization of blood glucose and blood pressure could be one of the important mechanisms used by E. senegalensis to protect the hypertensive diabetic's heart [8]. Furthermore, the oxidative stress observed in the aorta and heart of hypertensive diabetic rats is due to the direct action of alcohol and sucrose on the production and bioavailability of NO, which is a potent vasodilator, through inhibition of endothelial nitric oxide synthase (eNOS) [31].…”

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Inherited and Acquired Rhythm Disturbances in Sick Sinus Syndrome, Brugada Syndrome, and Atrial Fibrillation: Lessons from Preclinical Modeling

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