Predictive Factors of Subepithelial Tumor and Gastrointestinal Stromal Tumor in the Patients with Upper Gastrointestinal Subepithelial Lesions

Cha, Ra Ri; Oh, Hye Won; Yoo, Hyun Seon; Hong, Jeong Woo; Lee, Sang Soo; Kim, Hong Jun; Ha, Chang Yoon; Kim, Hyun Jin; Kim, Tae Hyo; Lee, Ok-Jae

doi:10.4166/kjg.2014.64.4.189

Cited by 2 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NETs of the GI tract are a heterogeneous group of neoplasms with a different clinical course and prognosis. 13 , 20 The incidence of these tumors in the duodenum is rising, 2 but they are still infrequent. There have been important additions to the literature on duodenal NENs, largely on epidemiological and pathological aspects.…”

Section: Discussionmentioning

confidence: 99%

“…It might be a reflection of the lack of homogeneous consensus on the optimal duration of this period and the need for a clinical or histopathological risk profile that helps select patients who need a long‐term follow‐up. 2 , 20 …”

Section: Discussionmentioning

confidence: 99%

“… 3 , 4 , 12 In fact, there is no consensus on the clinical practice guidelines regarding certain prognosis factors such as tumor size, vascular invasion, or tumor depth. 20 Moreover, it is still difficult to establish a validated protocol to address the existence of synchronous tumors and the criteria of familiar screening. Therefore, more evidence about the natural course, clinical presentation, and prognosis factors of these neoplasms is necessary.…”

Section: Discussionmentioning

confidence: 99%

“… 19 Metastases to lymph nodes can occur in 40%–60% of cases and liver metastases in up to 10% of patients. 20 , 21 However, despite this advanced presentation at diagnosis, most patients have prolonged survival due to a low proliferative rate of the tumors. Patients with well‐differentiated duodenal NETs and localized disease have a 5‐year overall survival rate of 80%–85%.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sporadic, non‐functional, gastrin‐producing duodenal neuroendocrine tumors: A retrospective study of an infrequent disease

Huerta

Fernández

Sánchez-Moreno

et al. 2022

J of Digest Diseases

View full text Add to dashboard Cite

Objectives Non‐functioning gastrin‐producing neuroendocrine neoplasms (NEN) of the duodenum are rare gastrointestinal tumors without a clinical syndrome due to gastrin production. Their incidence has significantly increased as an incidental finding during endoscopic studies. The aim of this study was to describe the characteristics and prognostic factors of this emergent and infrequent neoplasm. Methods We performed a retrospective observational study based on the duodenal NENs samples with positive staining for gastrin at the Department of Pathology, University Hospital 12‐de‐Octubre (Madrid, Spain) between 2000 and 2017. Patients with clinically functional tumors ([Zollinger–Ellison syndrome] or gastrin >1000 pg/mL), with previously diagnosed multiple endocrine neoplasia (MEN) syndrome or synchronous neoplasia were excluded. Clinicopathological and therapeutic variables, follow‐up, recurrence, and mortality data were collected. Results In all, 21 patients were included. Most of the tumors were diagnosed incidentally as a single small polypoid lesion limited to mucosa/submucosa and with a low histological grade. Four (19.0%) patients presented with metastatic involvement at diagnosis (lymphatic and/or hepatic). These four patients also had a high or intermediate mitotic grade and infiltration further than submucosa. Local resection was applied in most cases as curative treatment. There were two cases of tumor recurrence and two tumor‐related deaths with a 5‐year disease‐free survival of 81.0%. Conclusions The majority of these tumors were diagnosed at a localized stage and had a good prognosis with treatment. Nevertheless, given the potential metastatic risk, a close follow‐up is necessary, especially in those with aggressive pathological factors such as deep infiltration or high histological grade.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%