Predictive factors of six-week mortality in critically ill patients with SARS-CoV-2: A multicenter prospective study

Estella, Ángel; Garmendia, J.L. García; Fuente, Carmen de la; Casas, J Felipe; Yuste, M. E.; Villar, Rosario Amaya; Estecha, MA; Mateos, Luis Yaguez; Bulnes, M.L. Cantón; Loza, Ana; Mora, J.; Ruiz, L Fernández; Fernández, Begoña; Amezcua, M. Rojas; Higueras, Manuel; Torres, Irene Garralda; Núñez, María Recuerda; Beryanaki, Medhi Zaheri; Espinar, F. Rivera; Zapata, Daniel; Cano, Sara Guadalupe Moreno; Beltrán, Beatriz; Muñoz, Nelson; Piñero, Antoni; Bueno, P Bustelo; Barriga, E. Moreno; Toro, Juan J.; Ruiz, Miriam Pérez; González, Cristina Gómez; Flores, A Breval; Gómez, Andrea; Jiménez, Marta; Marín, Mercedes; Ordiales, A. Ortega; Tejero-Aranguren, J.; Mejías, Cuesta; Oña, Juan Gómez de; Hoz, Claudio de la; Fernandez, Daniel; Cuadros, S. Ibañez; Garnacho-Montero, José

doi:10.1016/j.medine.2021.02.008

Cited by 6 publications

(2 citation statements)

References 55 publications

(54 reference statements)

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“…After screening by abstract and title, 571 articles were selected for full-text assessment. In total, 157 studies evaluating 948,309 patients were included in the meta-analysis (9–159). The characteristics of all the included studies are shown in Table S1 (http://links.lww.com/CCX/B152).…”

Section: Resultsmentioning

confidence: 99%

Intensive Care and Organ Support Related Mortality in Patients With COVID-19: A Systematic Review and Meta-Analysis

Chandel

Leazer

Alcover

et al. 2023

Critical Care Explorations

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OBJECTIVES:To perform a systematic review and meta-analysis to generate estimates of mortality in patients with COVID-19 that required hospitalization, ICU admission, and organ support.DATA SOURCES: A systematic search of PubMed, Embase, and the Cochrane databases was conducted up to December 31, 2021.STUDY SELECTION: Previously peer-reviewed observational studies that reported ICU, mechanical ventilation (MV), renal replacement therapy (RRT) or extracorporeal membrane oxygenation (ECMO)-related mortality among greater than or equal to 100 individual patients.DATA EXTRACTION: Random-effects meta-analysis was used to generate pooled estimates of case fatality rates (CFRs) for in-hospital, ICU, MV, RRT, and ECMO-related mortality. ICU-related mortality was additionally analyzed by the study country of origin. Sensitivity analyses of CFR were assessed based on completeness of follow-up data, by year, and when only studies judged to be of high quality were included.

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Section: Resultsmentioning

confidence: 99%

Intensive Care and Organ Support Related Mortality in Patients With COVID-19: A Systematic Review and Meta-Analysis

Chandel

Leazer

Alcover

et al. 2023

Critical Care Explorations

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“…Regarding antibiotic use, we found that the group that died had a significantly higher percentage of use of antibiotics, whereas other cohorts found no differences among groups. [ 27 ] On the other hand, immunomodulatory treatment with tocilizumab was utilized only in 2.3% of participants in the survival group and 3.8% in non-survivors. This is intriguing because, by May 2021, the RECOVERY trial proved the efficacy of tocilizumab to improve survival and other clinical outcomes in patients with hypoxia and systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for COVID-19 and their association with mortality in Ecuadorian patients admitted to the ICU: A retrospective cohort multicentric study

Fuenmayor-González,

Vera-Ormaza,

Shen

et al. 2024

Medicine

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Several risk factors were associated with mortality in patients with coronavirus disease 2019 (COVID-19) infection in intensive care units (ICU). We assessed the effect of risk factors related to the characteristics and clinical history of the population, laboratory test results, drug management, and type of ventilation on the probability of survival/discharge from the ICU. A retrospective cohort multicentric study of adults with COVID-19 admitted to the ICU between March 2020 and December 2021. Data were collected from 6 hospitals in 5 cities in Ecuador. The primary outcome was ICU survival/discharge. Survival analysis was conducted using semi-parametric Cox proportional hazards models. Of those admitted to the ICU with COVID-19, (n = 991), mean age was 56.76 ± 13.14, and 65.9% were male. Regarding the primary outcome, 51.1% (n = 506) died and 48.9% (n = 485) survived. Of the group that died, their mean age was higher than the survivors (60.7 vs 52.60 years, respectively), and they had a higher prevalence of comorbidities such as arterial hypertension (37.2% vs 20.4%, respectively) and diabetes mellitus (26.9% vs 15.7%, respectively), with P < .001. In ventilatory management, 32.7% of patients used noninvasive ventilation and high-flow nasal cannula, and 67.3% required invasive ventilatory support. After adjusting for confounders, Cox regression analysis showed that patients were less likely to be discharged alive from the ICU if they met the following conditions: arterial hypertension (hazard ratio [HR] = 0.83 95% CI 0.723–0.964), diabetes mellitus (HR = 0.80 95% CI 0.696–0.938), older than 62 years (HR = 0.86 95% CI 0.790–0.956), obese (body mass index ≥ 30) (HR = 0.78 95% CI 0.697–0.887), 1 unit increase in SOFA score (HR = 0.94 95% CI 0.937–0.961), PaO2/FiO2 ratio <100 mm Hg (HR = 0.84 95% CI 0.786–0.914), and the use of invasive mechanical ventilation (HR = 0.68 95% CI 0.614–0.769). Risk factors associated with increased mortality were older age, obesity, arterial hypertension, and diabetes. Factors such as male gender, chronic obstructive pulmonary disease, acute kidney injury, and cancer reported in other investigations did not have the same effect on mortality in our study.

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SARS-CoV-2 and COVID-19: A Narrative Review

Blann¹,

Heitmar²

2022

Br J Biomed Sci

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Predictive factors of six-week mortality in critically ill patients with SARS-CoV-2: A multicenter prospective study

Cited by 6 publications

References 55 publications

Intensive Care and Organ Support Related Mortality in Patients With COVID-19: A Systematic Review and Meta-Analysis

Intensive Care and Organ Support Related Mortality in Patients With COVID-19: A Systematic Review and Meta-Analysis

Risk factors for COVID-19 and their association with mortality in Ecuadorian patients admitted to the ICU: A retrospective cohort multicentric study

SARS-CoV-2 and COVID-19: A Narrative Review

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