Predictive factors of sentinel lymph node failed mapping in endometrial carcinoma patients: a systematic review and meta-analysis

Raffone, Antonio; Fanfani, Francesco; Raimondo, Diego; Rovero, Giulia; Renzulli, Federica; Travaglino, Antonio; Laurentiis, Umberto De; Santoro, Angela; Zannoni, Gian Franco; Casadio, Paolo; Scambia, Giovanni; Seracchioli, Renato; Mollo, Antonio

doi:10.1136/ijgc-2022-004014

Cited by 8 publications

(4 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The article by Raffone et al8 will certainly add to the current literature surrounding the art of SLN mapping. The results of this study provide us with useful information to work towards the overarching goal of successful SLN assessment—detecting low-volume endometrial cancer while decreasing the risk of comorbidities for our patients.…”

mentioning

confidence: 97%

“…Raffone et al report the results of their systematic review and meta-analysis assessing predictive factors of failed SLN mapping, defined as an inability to identify at least one SLN in each hemi-pelvis, in patients with endometrial cancer. 8 Their analysis included observational cohort studies that assessed predictive factors of failed SLN mapping in patients with earlystage endometrial cancer undergoing SLN biopsy using an indocyanine green (ICG) cervical injection. They identified six studies, published between 2016 and 2020, with a total of 1345 patients for final analysis.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Mapping the landscape of sentinel lymph nodes in endometrial cancer: let us continue in the right direction

Kahn

Leitao

2023

Int J Gynecol Cancer

View full text Add to dashboard Cite

mentioning

confidence: 97%

mentioning

confidence: 99%

Mapping the landscape of sentinel lymph nodes in endometrial cancer: let us continue in the right direction

Kahn

Leitao

2023

Int J Gynecol Cancer

View full text Add to dashboard Cite

“…Consistent with the current literature, our study results showed excellent bilateral and unilateral detection rates for SLN mapping with ICG in endometrial cancer [ 8 , 10 , 20 ]. As previously described, the failure of SLN mapping with ICG is associated with advanced tumor stage, enlarged lymph nodes, and lymph node involvement but not with LVSI [ 12 , 18 ]. This is also reflected in our population with similar SLN detection rates in LVSI-negative and LVSI-positive tumors.…”

Section: Discussionmentioning

confidence: 94%

“…While the literature shows that LVSI is not associated with failed SLN mapping [ 12 , 18 ], evidence on the reliability of SLN mapping in patients with LVSI-positive endometrial cancer is scarce. The aim of this study was to determine the impact of LVSI on the diagnostic performance of SLN mapping.…”

Section: Introductionmentioning

confidence: 99%

Real-World Data Assessing the Impact of Lymphovascular Space Invasion on the Diagnostic Performance of Sentinel Lymph Node Mapping in Endometrial Cancer

Buechi,

Siegenthaler,

Sahli

et al. 2023

Cancers

View full text Add to dashboard Cite

Background: SLN mapping has emerged as a standard of care in endometrial cancer due to its high sensitivity and significant reduction in morbidity. Although lymphovascular space invasion (LVSI) is a known risk factor for lymph node metastasis and recurrence, evidence on the reliability of SLN mapping in LVSI-positive patients is scarce. The aim of this study was to determine the impact of LVSI on the diagnostic performance of SLN mapping. Methods: This retrospective cohort study included patients with endometrial cancer who underwent primary surgical treatment at the Bern University Hospital, Switzerland, between 2012 and 2022. Results: LVSI was present in 22% of patients and was significantly associated with lymph node metastasis (p < 0.001) and recurrence (p < 0.001). In node-negative patients with only SLN mapping performed, LVSI was an independent predictor of recurrence during multivariable Cox regression analysis (p = 0.036). The negative predictive value of SLN mapping was 91.5% and was significantly lower in tumors with LVSI (75.0%) compared to LVSI-negative tumors (95.6%, p = 0.004). Conclusion: The presence of LVSI was significantly associated with worse oncological outcomes. LVSI was an independent predictor of recurrence in node-negative patients with only SLN mapping performed. Furthermore, the negative predictive value of SLN mapping was significantly lower in LVSI-positive tumors.

show abstract

Comparison of sentinel lymph node distribution and lymphatic drainage pathway between high- and low-risk endometrial cancers

Chen

Liang

et al. 2023

Arch Gynecol Obstet

View full text Add to dashboard Cite

This study aimed to compare the distribution and drainage pathway of sentinel lymph nodes between high-and low-risk endometrial cancers. MethodsIn total, 429 patients with endometrial cancer who underwent sentinel lymph node biopsy in Peking University People's Hospital from July 2015 to April 2022 were retrospectively enrolled. There were 148 patients in the high-risk group and 281 patients in the low-risk group. ResultsThe unilateral and bilateral detection rates of sentinel lymph nodes were 86.5% and 55.9%, respectively.The highest detection rate was achieved in the subgroup with a combined use of Indocyanine green (ICG) and Carbon nanoparticles (CNP) (94.9% for unilateral detection and 66.7% for bilateral detection). The upper paracervical pathway (UPP) was detected in 93.3% of cases in the high-risk group and 96.0% of cases in the low-risk group (p = 0.261). The lower paracervical pathway (LPP) was detected in 10.0% of cases in the high-risk group and 17.9% of cases in the low-risk group (p = 0.048). Remarkably increased detection rates of SLN in the common iliac (7.5%) and para-aortic or precaval areas (2.9%) were observed in the high-risk group. In contrast, a markedly decreased detection rate of SLN in the internal iliac area (1.9%) was observed in the high-risk group. ConclusionThe combined use of ICG and CNP improved the bilateral detection rate of SLN in the high-risk group. The detection of UPP is important for both high-risk and low-risk cases, while LPP detection plays a more important role in the low-risk group. Lymphadenectomy in the common iliac and para-aortic or precaval areas is essential for patients with high-risk EC. Removal of internal iliac lymph nodes is essential for patients with low-risk EC, in case of ineffective SLN mapping.

show abstract

Predictive factors of sentinel lymph node failed mapping in endometrial carcinoma patients: a systematic review and meta-analysis

Cited by 8 publications

References 34 publications

Mapping the landscape of sentinel lymph nodes in endometrial cancer: let us continue in the right direction

Mapping the landscape of sentinel lymph nodes in endometrial cancer: let us continue in the right direction

Real-World Data Assessing the Impact of Lymphovascular Space Invasion on the Diagnostic Performance of Sentinel Lymph Node Mapping in Endometrial Cancer

Comparison of sentinel lymph node distribution and lymphatic drainage pathway between high- and low-risk endometrial cancers

Contact Info

Product

Resources

About