Predictive factors of postoperative diabetes insipidus in 333 patients undergoing transsphenoidal surgery for non-functioning pituitary adenoma

Kinoshita, Yasuyuki; Taguchi, Akira; Tominaga, Atsushi; Sakoguchi, Tetsuhiko; Arita, Kazunori; Yamasaki, Fumiyuki

doi:10.1007/s11102-021-01175-y

Cited by 14 publications

(21 citation statements)

References 21 publications

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“…Consistent with the previous results with DHEA, utamide did not inhibit the synaptogenic effects of DHT. Also Leydig cell had been previously linked to male hypogonadism which in agreement with hypogodanism (Bhasin, 2010;Morakinyo, 2014;Beattie, 2015;Grossmann, 2021;Kinoshita, 2022). Upon analysis the characterization of cellular changes occurring in the cortico-hippocampal regions in models of androgen deprived insulin-resistant adult male rats was determined.…”

Section: Resultsmentioning

confidence: 78%

Characterization of Hippocampal Synaptic Plasticity in Orchidectomized Insulin-resistant Rats

Akinbampe

Abayomi

Opuwari

et al. 2022

Preprint

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BackgroundAndrogen deprivation can be achieved through testosterone antagonists (chemical castration) with or without orchidectomy. There is this hypothesis that stipulates that testesterone exerts supreme effects on synaptic plasticity, however low testosterone has been linked to type- 2 diabetics mellitus, insulin resistance and Alzheimer’s disease. The aim of the study was to investigate the cellular changes that occur from bilateral orchidectomy and examine the effects of androgen deprivation, orchidectomy and flutamide administration on the histoarchitectural organization of the hippocampus in male Wistar rats. MethodologyThirty-six (36) adult male Wistar rats were randomly divided into into six (6) groups: Control group (distilled water),orchidectomy group (bilateral orchidectomy), flutamide group (oral 10mg,20mg), orchidectomy+flutamide. Animals were sacrificed at 30 days respectively. ResultsThe total plasma; testesterone, insulin levels, fasting blood glucose, and nitric oxide were assayed; the homeostasis model for insulin resistance was also calculated. Histological examinations by Hematoxylin and Eosin(H&E) and Cresyl fast violet (CFV), while immunohistochemical analysis of astrocytes were performed using Glial fibrillary acidic protein (GFAP). Results of study show that androgen deprived insulin-resistance state primarily affects fasting blood glucose and lead to increases in the level of serum insulin, glucose and nitric oxide and caused a decrease in serum testosterone levels. The hippocampal response to flutamide was unaffected by blockade of intracerebral estrogen biosynthesis. In comparison flutamide alone increased CA1 spine synapse density also whereas in combination the effects of flutamide+orchidectomy were additive rather than inhibitory. ConclusionHistopathological results showed that flutamide significantly restored the histological damage of rat brain in flutamide treatment+ orchidectomy.

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Section: Resultsmentioning

confidence: 78%

Characterization of Hippocampal Synaptic Plasticity in Orchidectomized Insulin-resistant Rats

Akinbampe

Abayomi

Opuwari

et al. 2022

Preprint

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“…18 In a larger retrospective study including 333 patients with NFPAs, postoperative DI occurred in 21.7% of patients undergoing initial TSS, being permanent in 2 (0.6%). 19…”

Section: Neurosurgery or Traumamentioning

confidence: 99%

“…T1-weighted magnetic resonance imaging (MRI). 19 Transient CDI typically occurs within 24-48 h after surgery and resolves during the next 2 weeks 88 (Table 2). Post-operative CDI may also occur in combination with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in the triphasic response.…”

Section: Septo-optic Dysplasia (Sod)mentioning

confidence: 99%

“…A new diagnosis of post‐operative CDI was made in 7.5% of 160 patients with non‐functioning pituitary adenomas (NFPAs) undergoing initial eTSS, being permanent in only 2.5.% 18 . In a larger retrospective study including 333 patients with NFPAs, post‐operative DI occurred in 21.7% of patients undergoing initial TSS, being permanent in 2 (0.6%) 19 …”

Section: Causes and Classification Of DImentioning

confidence: 99%

“…Several factors have been described as predictors of CDI following TSS including younger patient age, larger tumour size and the absence of the “bright spot” of the posterior pituitary in pre‐operative T1‐weighted magnetic resonance imaging (MRI) 19 . Transient CDI typically occurs within 24–48 h after surgery and resolves during the next 2 weeks 88 (Table 2).…”

Section: Pathogenesis and Molecular Genetics Of DImentioning

confidence: 99%

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New developments and concepts in the diagnosis and management of diabetes insipidus (AVP‐deficiency and resistance)

Angelousi

Alexandraki

Mytareli

et al. 2023

J Neuroendocrinology

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Diabetes insipidus (DI) is a disorder characterised by the excretion of large amounts of hypotonic urine, with a prevalence of 1 per 25,000 population. Central DI (CDI), better now referred to as arginine vasopressin (AVP)‐deficiency, is the most common form of DI resulting from deficiency of the hormone AVP from the pituitary. The less common nephrogenic DI (NDI) or AVP‐resistance develops secondary to AVP resistance in the kidneys. The majority of causes of DI are acquired, with CDI developing when more than 80% of AVP‐secreting neurons are damaged. Inherited/familial CDI causes account for approximately 1% of cases. Although the pathogenesis of NDI is unclear, more than 280 disease‐causing mutations affecting the AVP2 protein or AVP V2 receptor, as well as in aquaporin 2 (AQP2), have been described. Although the cAMP/protein kinase A pathway remains the major regulatory pathway of AVP/AQP2 action, in vitro data have also revealed additional cAMP independent pathways of NDI pathogenesis. Diagnosing partial forms of DI, and distinguishing them from primary polydipsia, can be challenging, previously necessitating the use of the water deprivation test. However, measurements of circulating copeptin levels, especially after stimulation, are increasingly replacing the classical tests in clinical practice because of their ease of use and high sensitivity and specificity. The treatment of CDI relies on desmopressin administration, whereas NDI requires the management of any underlying diseases, removal of offending drugs and, in some cases, administration of diuretics. A better understanding of the pathophysiology of DI has led to novel evolving therapeutic agents that are under clinical trial.

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Predictors of the Spontaneous Resolution of Central Diabetes Insipidus Following Endoscopic Endonasal Surgery for Craniopharyngioma

Pan¹,

Qi²,

Wu³

et al. 2023

World Neurosurgery

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Predictive factors of postoperative diabetes insipidus in 333 patients undergoing transsphenoidal surgery for non-functioning pituitary adenoma

Cited by 14 publications

References 21 publications

Characterization of Hippocampal Synaptic Plasticity in Orchidectomized Insulin-resistant Rats

Characterization of Hippocampal Synaptic Plasticity in Orchidectomized Insulin-resistant Rats

New developments and concepts in the diagnosis and management of diabetes insipidus (AVP‐deficiency and resistance)

Predictors of the Spontaneous Resolution of Central Diabetes Insipidus Following Endoscopic Endonasal Surgery for Craniopharyngioma

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