Predictive factors of positive circumferential resection margin after radiochemotherapy for rectal cancer: The French randomised trial ACCORD12/0405 PRODIGE 2

Pre- and Post-Surgery Treatments in Rectal Cancer: A Long-Term Single-Centre Experience

“…Comparison of various schedules of rt and ccrt in terms of extension and dose used in past studies revealed no significant difference in long-course preoperative rt doses of 46 Gy and 50 Gy 43 , short-or long-course ccrt schedules 44 , or long-course preoperative rt at 45 Gy plus capecitabine compared with an intensified neoadjuvant ccrt schedule using 50 Gy plus capecitabine and oxaliplatin 45 . In our series, we preferred to choose short-course treatment based on the performance status of the patients rather than age.…”

Simple criteria to predict margin involvement after chemoradiotherapy and sphincter-sparing for low rectal cancer

“…The CRM þ factors strictly selected were the relevant and significant variables in the literature. These factors were the body mass index (BMI), 11 the CEA level, clinical pretherapeutic T (cT) and N (cN) staging, 9 response to CRT, 8 the interval between CRT and surgery, 12 the macroscopic tumor characteristics (fixity, annularity, location, size) 10,13e15 and operative pelvic difficulties. This was followed by a multivariate logistic regression model which included all of the variables with a p value 0.20.…”

Can Induction Chemotherapy before Concurrent Chemoradiation Impact Circumferential Resection Margin Positivity and Survival in Low Rectal Cancers?

“…After preoperative chemoradiation, positive CRM rate can vary between 3-14% Kellokumpu et al, 2012;Kenelley et al, 2013;Rullier et al, 2013;Calvo et al, 2014). CRM positivity as high as 26% has been reported in patients with low rectal cancers who undergo APR (Nagtegaal et al, 2002;Bernstein et al, 2009).…”

“…It remains unclear if preoperative chemoradiation alters CRM status (Gosens et al, 2007;Smith et al, 2010;Rullier et al, 2013). Preoperative chemoradiation reduces locoregional recurrence but does not alter systemic relapse which is the most common mode of failure in these patients (Gao et al, 2014).…”