Predictive factors of overall and major postoperative complications after partial nephrectomy: Results from a multicenter prospective study (The RECORd 1 project)
Abstract:Introduction and objectives: To analyze postoperative complications and to assess for significant predictive factors during partial nephrectomy (PN) using a large multicenter dataset. Conclusions: Comorbidities and surgical approach should be considered in preoperative evaluation of patients undergoing PN, as they resulted to play a significant role in the occurrence of postoperative complications.
“…In our present study, the overall postoperative surgical complication rate was 10.2% and the major surgical postoperative complication rate was 2.5%. These results represent a further demonstration of the increasing safety of this procedure over time and slightly exceed the perioperative results of the Italian registry of conservative surgery for renal tumours (RECORd 1 project) from 2008 to 2012, which reported an overall and major complication rate of 13.1% and 3.5%, respectively [4]. The overall and Clavien-Dindo Grade III complication rate reported in the present study was also lower compared to [15].…”
Section: Discussioncontrasting
confidence: 52%
“…Nevertheless, PN is a technical challenging procedure. Surgical complications are a prominent concern of PN, as they have been reported in up to 30% of cases [4,5]. Major surgical complications are also frequent (3-6% of cases) and can be potentially lifethreatening [6].…”
nomogram for predicting the risk of postoperative surgical complications. At decision curve analysis, the nomogram led to superior outcomes for any decision associated with a threshold probability of >5%.
ConclusionSeveral clinical predictors have been associated with postoperative surgical complications after PN. We used this information to develop and internally validate a nomogram to predict such risk.
“…In our present study, the overall postoperative surgical complication rate was 10.2% and the major surgical postoperative complication rate was 2.5%. These results represent a further demonstration of the increasing safety of this procedure over time and slightly exceed the perioperative results of the Italian registry of conservative surgery for renal tumours (RECORd 1 project) from 2008 to 2012, which reported an overall and major complication rate of 13.1% and 3.5%, respectively [4]. The overall and Clavien-Dindo Grade III complication rate reported in the present study was also lower compared to [15].…”
Section: Discussioncontrasting
confidence: 52%
“…Nevertheless, PN is a technical challenging procedure. Surgical complications are a prominent concern of PN, as they have been reported in up to 30% of cases [4,5]. Major surgical complications are also frequent (3-6% of cases) and can be potentially lifethreatening [6].…”
nomogram for predicting the risk of postoperative surgical complications. At decision curve analysis, the nomogram led to superior outcomes for any decision associated with a threshold probability of >5%.
ConclusionSeveral clinical predictors have been associated with postoperative surgical complications after PN. We used this information to develop and internally validate a nomogram to predict such risk.
“…The robotic approach has been widely adopted over the past 10 years and has allowed the treatment of more complex tumours and to expand the indications of minimally invasive PN . It is well‐known that RAPN is technically challenging and associated with a significant risk of complications, albeit this complication rate remains lower than the open approach . Despite many studies having assessed the relationship between provider volume and RAPN outcomes , to our knowledge no study to date has analysed both HV and SV.…”
“…Beyond a possible protective effect on postoperative RF, off-clamp PN could be associated with a higher complication and positive surgical margin (SM) rate due to a higher bleeding and a subsequent suboptimal vision [11]. Above all, plays the quality of renal parenchyma and comorbidities that are tightly related to kidney quality that represent unmodifiable factors that finally strongly affect postoperative RF setting the limits of functional recovery after PN [1,3,12,13].…”
a b s t r a c tPurpose: To evaluate the surgical and functional outcomes of a matched-paired series of on-clamp vs offclamp endoscopic robot-assisted simple enucleation (ERASE) and standardized renorraphy in a tertiary referral institution, to search for predictors of functional drop after surgery and to investigate the influence of off-clamp technique in patients presenting these characteristics. Materials and methods: A matched-pair comparison of 120 on-clamp vs 120 off-clamp over 491 patients treated with ERASE was performed. Perioperative and functional outcomes were compared between groups. Results: Patients treated with on-clamp and off-clamp technique had comparable complication and positive surgical margin rate. The off-clamp group had a significantly lower eGFR drop compared to the on-clamp group at 3rd postoperative day (POD) (1% vs 7%, p ¼ 0.0001) and at 30th POD (2.5% vs 9%, p ¼ 0.01) from baseline. This difference lost its statistical significance at 6th month and at last follow-up (median 40 months). At multivariable analysis the Charlson comorbidity index (OR 2.06, p < 0.0001), uncontrolled type 2 diabetes mellitus (OR 4.13, p < 0.001) were independent predictive factors of a >15% eGFR drop from baseline to last follow-up. In a subanalysis over 64 comorbid patients, those patients who underwent off-clamp ERASE had a significantly lower eGFR drop compared to the comorbid counterpart during the whole follow-up. Conclusions: The off-clamp ERASE is a safe surgical technique with a significantly lower renal function drop compared to on-clamp ERASE in the early perioperative time. Patients with comorbidity might represent a subgroup of patients having a functional benefit after off-clamp RAPN even in the long-term period.
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