Predictive Factors of Mortality in Burn Patients

Fazeli, Shahram; Karami-Matin, Reza; Kakaei, Neda; Pourghorban, Samira; Safari‐Faramani, Roya; Safari-Faramani, Bahare

doi:10.5812/traumamon.14480

Cited by 26 publications

(14 citation statements)

References 31 publications

(34 reference statements)

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“…Using the opportunity sampling technique of all data for patients admitted to the burns unit throughout the period of January 2005 to December 2017, a total of 1,288 admissions to the burns unit were included in the study. Data included the demographics, cause and type of burns and the affected total body surface area (TBSA) which are considered major risk factors for burn morbidity and mortality (22)(23)(24)(25). Data preview was limited to the research team and for research purposes only.…”

Section: Methodsmentioning

confidence: 99%

Patterns and Sequelae of burn injury at the Jordanian Royal Medical Services rehabilitation center in 2005-2017: a cross-sectional study

El-Maaytah¹,

Al-Bdour²,

Aldabbas³

et al. 2019

Electron. physician

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Background: Burns are not yet appropriately reported in Jordan; determining patterns provides critical input in construction of awareness programs and vital issues to be addressed while developing such programs to raise public awareness as well as to increase the safety measures in domestic settings, as prevention is better than cure. Objective: The aim of the study was to determine burns in Jordan in regard to patterns and sequelae. Methods: In this cross-sectional study, 1,288 records of patients with burns at the burns unit of the Royal Jordanian Rehabilitation Center (RJRC) between 2005 and 2017 were studied. Age, gender, total body surface area (TBSA), location of burn, admission date and time, location of incidence and mortality. All data were analyzed using descriptive statistics and Chi-square test. Results: Mean age was 31±26 years; the male-to-female ratio was 1.56:1 and 41.8% of victims admitted were at or below 14 years of age. The proportions of males and females with burn injury was not statistically significant by age group (p=0.8). A total of 90.5% were in a domestic environment and 64.5% were the result of direct flame burn, followed by scalding burns in about 25.3%. The most affected sites were limbs with the majority of patients with below 40% total body surface area (TBSA) affected and deep partial thickness. A further 218 cases were inhalational injuries. Mean of in-hospital stay was 18 days. The overall mortality rate was 14.6% and attributed to elevated TBSA, depth of the wound, presence of inhalational injury and flame type of burn. Age specific mortality were 7.9% and 19.15% in patient younger than 14 years of age and in older ones respectively Conclusion: As most burns appeared to be in domestic settings, raising public awareness and increasing safety measures in domestic settings will hopefully decrease burn incidence and its consequences. Teaching first aid to the population can also be beneficial in reducing the morbidity and mortality of burn.

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Section: Methodsmentioning

confidence: 99%

Patterns and Sequelae of burn injury at the Jordanian Royal Medical Services rehabilitation center in 2005-2017: a cross-sectional study

El-Maaytah¹,

Al-Bdour²,

Aldabbas³

et al. 2019

Electron. physician

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“…In another clinical study involving 4927 burn patients with an overall death of 5.3%, the mortality rate was approximately two-fold higher in women aged between 30 and 59 years compared to the same age group of male burn victims [ 161 ]. In fact, it has been shown that female gender is linked to a more detrimental outcome in the majority of clinical studies following burn trauma [ 6 , 162 , 163 , 164 ]. The reasons for adverse outcome in women are likely attributable to sex-specific differences in metabolic and neuroendocrine responses following burn injury [ 161 ].…”

Section: Other Biological Factors Related To Cardiac Dysfunction Amentioning

confidence: 99%

Pathological Responses of Cardiac Mitochondria to Burn Trauma

Wang

Scott

Koniaris

et al. 2020

IJMS

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Despite advances in treatment and care, burn trauma remains the fourth most common type of traumatic injury. Burn-induced cardiac failure is a key factor for patient mortality, especially during the initial post-burn period (the first 24 to 48 h). Mitochondria, among the most important subcellular organelles in cardiomyocytes, are a central player in determining the severity of myocardial damage. Defects in mitochondrial function and structure are involved in pathogenesis of numerous myocardial injuries and cardiovascular diseases. In this article, we comprehensively review the current findings on cardiac mitochondrial pathological changes and summarize burn-impaired mitochondrial respiration capacity and energy supply, induced mitochondrial oxidative stress, and increased cell death. The molecular mechanisms underlying these alterations are discussed, along with the possible influence of other biological variables. We hope this review will provide useful information to explore potential therapeutic approaches that target mitochondria for cardiac protection following burn injury.

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“…Previously conducted studies reported that the most common cause of death in patients with burns was flame burns. [4,21,[41][42][43] The pathogenesis of electrical burns has certain differences concerning the other types of burns (6). A study conducted on 964 patients in Iran by Aghazadeh et al [44] reported that death arose from scalding with flame, chemicals and hot liquid, respectively.…”

Section: Burning Aetiologymentioning

confidence: 99%

Factors Affecting The Mortality At Patients With Burns: Single Centre Results

Temiz

Albayrak

Peksöz³

et al. 2020

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Burns are a primary cause of mortality along with the severe physical and psychological morbidities in patients and their families. Such kinds of injuries bring about considerable financial burdens due to the treatment processes and sequels. The present study aims to investigate the factors that affect the mortality of burns. METHODS: The archives files of the patients admitted because of burn injuries in our burn centre between September 2008 and December 2016 were examined in this study. Some of the lab values, such as age, sex, percentage of total burn surface area (TBSA), referral status, burning site, degree of burns, time of admission to hospital, aetiology of burning, blood and blood products collection, complete blood count, routine biochemistry, coagulation parameters, C-reactive protein (CRP), sedimentation rate, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), were examined while evaluating the patients' mortalities. RESULTS: A total of 133 patients were included in this study. The patient's age (p=0.001), the degree of burns (p<0.001), surface area of burns (p<0.001), the time of hospital admission (p<0.001), burning aetiology (p=0.006), erythrocyte suspension, fresh frozen plasma, along with the administration of albumin transfusion (p<0.001), mean platelet volume (MPV) (p=0.028), NLR (p<0.001) and PLR (p<0.030) values were found to be associated with mortality in patients with burns. CONCLUSION: In this study, age, burn grade, TBSA, hospital admission time, burn aetiology, erythrocyte, fresh frozen plasma and albumin transfusion, MPV, NLR and PLR values were found to be associated with mortality in patients with burns. With this study, it is possible to produce the treatment guidelines to reduce mortality by taking these parameters into consideration, which were determined to be associated with mortality while evaluating the patients with burns.

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Predictive Factors of Mortality in Burn Patients

Cited by 26 publications

References 31 publications

Patterns and Sequelae of burn injury at the Jordanian Royal Medical Services rehabilitation center in 2005-2017: a cross-sectional study

Patterns and Sequelae of burn injury at the Jordanian Royal Medical Services rehabilitation center in 2005-2017: a cross-sectional study

Pathological Responses of Cardiac Mitochondria to Burn Trauma

Factors Affecting The Mortality At Patients With Burns: Single Centre Results

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