Predictive factors of functional capacity and real-world functioning in patients with schizophrenia

Menéndez-Miranda, Isabel; García-Portilla, María Paz; Álvarez, Leticia García; Arrojo, Manuel; Sánchez, Pedro; Sarramea, Fernando; Gomar, Jesús J.; Bobes-Bascarán, María Teresa; Sierra, Pilar; Sáiz, Pilar A.; Bobes, Julio

doi:10.1016/j.eurpsy.2014.12.011

Cited by 42 publications

(34 citation statements)

References 37 publications

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“…Schizophrenia is associated with substantial impairments in functional outcomes, including social and occupational functioning, independent living, and the ability to perform activities of daily living ( Green, Kern, Braft, & Mints, 2000 ). Additionally, several studies have shown that cognitive functions are impaired in patients with schizophrenia, and these impairments also have a real impact on the daily functioning of patients with this disorder ( García-Portilla et al, 2014 , Gavilán and García-Albea, 2014 , Menéndez-Miranda et al, 2015 ). They include significant deficits in memory, attention, problem solving, processing speed, and social cognition, which have been shown to be associated with several of the aforementioned functional impairments ( Keefe et al, 2013 ).…”

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confidence: 99%

Psychometric properties of a Spanish-version of the Schizophrenia Objective Functioning Instrument (Sp-SOFI)

Al‐Halabí

Sáiz

Garrido

et al. 2016

International Journal of Clinical and Health Psychology

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The Schizophrenia Objective Functioning Instrument (SOFI) is an interviewer-administered scale designed to objectively assess the actual level of patient functioning and to measure community functioning related to cognitive impairment and psychopathology. The aim was to examine the psychometric properties of the Spanish version of the SOFI (Sp-SOFI) in a sample of 155 Spanish outpatients with schizophrenia disorder. The instruments applied were Sp-SOFI, Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression-Schizophrenia Scale (CGI-SCH), Personal and Social Performance Scale (PSP), and Global Assessment of Functioning (GAF). The discrimination indexes of the Sp-SOFI items range from .21 to .77. Exploratory factor analysis showed an essentially one-dimensional structure. Cronbach's alpha was .93. Test-retest reliability for the Sp-SOFI total score was .87 (p < .001). The canonical correlation between SP-SOFI domains and PSP dimensions was .83. The multiple correlation coefficient between Sp-SOFI domains and GAF score was .84. Sp-SOFI scores were significantly different between high and low scores on the PANSS scales (p < .001). Sp-SOFI measures discriminated among patients with doubtful, mild, moderate, and severe schizophrenia disorder according to CGI-SCH scales (p < .001). New evidence about the validity of the SOFI was provided. The Sp-SOFI is a reliable and valid tool for using in clinical practice.

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confidence: 99%

Psychometric properties of a Spanish-version of the Schizophrenia Objective Functioning Instrument (Sp-SOFI)

Al‐Halabí

Sáiz

Garrido

et al. 2016

International Journal of Clinical and Health Psychology

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“…13 Positive symptoms can affect specific areas, such as self-care and aggressive behavior, but tend to be clinically relived through antipsychotic treatment. 35 Thus, it is interesting to see whether blood cytokine levels in early stage of SCz can predict the final therapeutic effect of these symptoms and whether they can reduce negative and depressive symptoms that may lead to a reduction in the level of disability. Our research showed that higher IL-6 levels predict a reduced improvement in depressive symptoms.…”

Section: Discussionmentioning

confidence: 99%

<p>The Role of Cytokines in Predicting the Efficacy of Acute Stage Treatment in Patients with Schizophrenia</p>

Fan

et al. 2020

NDT

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Purpose: Inflammatory response in schizophrenia (SCz) is related to its underlying pathological mechanism and might be significant in deciding a patient's prognosis. The current study aims to investigate the differences in the serum inflammation level between schizophrenic patients and healthy controls and identify inflammatory markers that can predict clinical therapeutic effects in early-stage SCz patients at the 6-month follow-up. Patients and Methods: In total, 71 subjects were recruited in this study, including 35 patients with Scz and 36 healthy controls. The 35 Scz patients, who were in the first-episode or acute relapse state at admission, had completed the 6-month follow-up. The Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression (CGI) assessment results, demographic details, and blood samples were collected at the baseline and at followup. Data were analyzed using the Spearman correlation and multiple linear regression. Results: Serum interleukin (IL-1β, IL-4, IL-6, and IL-8) levels were significantly elevated in SCz patients at baseline compared with healthy controls, with a reduced IL-8 level at the follow-up. Furthermore, a higher IL-6 level and lower IL-8 level was found to predict better improvement in negative symptoms. The higher IL-6 level also predicted lesser improvement in depressive symptoms. Finally, a higher interferon (IFN)-γ level predicted a lower therapeutic effect for excitatory symptoms. Conclusion: The serum levels of inflammatory markers were higher in patients with SCz than in healthy controls. These markers can be considered accurate predictors of therapeutic effects in patients with SCz.

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“…Recovery obviously depends on remission. Nevertheless, there are a number of other intervening factors affecting recovery that are responsible for the marked variation in outcome observed (Menendez-Miranda et al, 2015;Jordan et al, 2014).…”

Section: Introductionmentioning

confidence: 98%

Understanding the impact of persistent symptoms in schizophrenia: Cross-sectional findings from the Pattern study

Haro

Altamura

Corral

et al. 2015

Schizophrenia Research

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Predictive factors of functional capacity and real-world functioning in patients with schizophrenia

Cited by 42 publications

References 37 publications

Psychometric properties of a Spanish-version of the Schizophrenia Objective Functioning Instrument (Sp-SOFI)

Psychometric properties of a Spanish-version of the Schizophrenia Objective Functioning Instrument (Sp-SOFI)

<p>The Role of Cytokines in Predicting the Efficacy of Acute Stage Treatment in Patients with Schizophrenia</p>

Understanding the impact of persistent symptoms in schizophrenia: Cross-sectional findings from the Pattern study

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