Predictive factors of Boston Type I Keratoprosthesis outcomes: A long-term analysis

Kanu, Levi N.; Niparugs, Muanploy; Nonpassopon, Manachai; Karas, Faris I.; Cruz, J.M.; Cortina, María Soledad

doi:10.1016/j.jtos.2020.07.012

Cited by 12 publications

(15 citation statements)

References 43 publications

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“…The inflammation associated with OSD might have been the cause of the persistent epithelial defects in those eyes, which in turn made them vulnerable to infection and extrusion. 24,33 In this study, RPM formation was the most common postoperative complication, and it has ranged between 14% and 65% in other studies. 1,7,9,14,27,34 The development of RPM is associated with anterior segment inflammation, which might explain why the eyes with OSD in this study had more RPM formation than those without.…”

Section: Discussionmentioning

confidence: 60%

“…The device anatomical-retention rate of 88.9%, found at the mean follow-up time of 83.4 months, was comparable to the reported international long-term results of 79%-89.2%. 8,13,25,26 Apart from the anatomical aspects, the effectiveness of vision can be evaluated by the ability to perform visual orientation. 29 Therefore, meticulous patient selection for surgery is recommended to achieve the most favorable visual function.…”

Section: Discussionmentioning

confidence: 99%

“…6,[19][20][21] As to previous studies on KPro anatomical retention and complications, 7,14,[22][23][24] few have described the long-term outcomes. 8,13,25,26 There is also limited data on whether topical antimicrobial regimens can prevent KPro infections, including fungal infections, especially in high-prevalence areas. The current study therefore set out to describe the long-term visual outcomes and anatomical retention of Boston type I KPro, the risk factors for the outcomes, and the efficacies of prophylactic antimicrobial regimens.…”

Section: Introductionmentioning

confidence: 99%

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Long-term Outcomes of Boston Type I Keratoprosthesis, and Efficacy of Amphotericin B and Povidone-Iodine in Infection Prophylaxis

Prabhasawat

Chotikavanich

Ngowyutagon

et al. 2021

American Journal of Ophthalmology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long-term Outcomes of Boston Type I Keratoprosthesis, and Efficacy of Amphotericin B and Povidone-Iodine in Infection Prophylaxis

Prabhasawat

Chotikavanich

Ngowyutagon

et al. 2021

American Journal of Ophthalmology

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“…A meta-analysis of 406 articles found that 60% of patients had 6/60 vision or better at 2 years and 51% at 5 years ( 45 ). Kanu et al found 75 and 66.7% of patients had improved VA at 5 and 10 years, respectively ( 46 ). Often, VA improves the longer the KPro has been implanted.…”

Section: Hard Keratoprosthesesmentioning

confidence: 99%

Artificial Cornea: Past, Current, and Future Directions

et al. 2021

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Corneal diseases are a leading cause of blindness with an estimated 10 million patients diagnosed with bilateral corneal blindness worldwide. Corneal transplantation is highly successful in low-risk patients with corneal blindness but often fails those with high-risk indications such as recurrent or chronic inflammatory disorders, history of glaucoma and herpetic infections, and those with neovascularisation of the host bed. Moreover, the need for donor corneas greatly exceeds the supply, especially in disadvantaged countries. Therefore, artificial and bio-mimetic corneas have been investigated for patients with indications that result in keratoplasty failure. Two long-lasting keratoprostheses with different indications, the Boston type-1 keratoprostheses and osteo-odonto-keratoprostheses have been adapted to minimise complications that have arisen over time. However, both utilise either autologous tissue or an allograft cornea to increase biointegration. To step away from the need for donor material, synthetic keratoprostheses with soft skirts have been introduced to increase biointegration between the device and native tissue. The AlphaCor™, a synthetic polymer (PHEMA) hydrogel, addressed certain complications of the previous versions of keratoprostheses but resulted in stromal melting and optic deposition. Efforts are being made towards creating synthetic keratoprostheses that emulate native corneas by the inclusion of biomolecules that support enhanced biointegration of the implant while reducing stromal melting and optic deposition. The field continues to shift towards more advanced bioengineering approaches to form replacement corneas. Certain biomolecules such as collagen are being investigated to create corneal substitutes, which can be used as the basis for bio-inks in 3D corneal bioprinting. Alternatively, decellularised corneas from mammalian sources have shown potential in replicating both the corneal composition and fibril architecture. This review will discuss the limitations of keratoplasty, milestones in the history of artificial corneal development, advancements in current artificial corneas, and future possibilities in this field.

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“…Also the rate of postoperative complications is high and includes: glaucoma, retroprosthetic membrane formation, keratolysis, endophthalmitis, vitreoretinal complications, such as retinal detachment, cystoid macular edema, uveitis and hypotony/phthisis. In the latest study of the long term BKPro outcomes published in 2020, the probability of maintaining or improving vision was 75,0% at 5 years and 66,7% at 10 years [56].…”

Section: Surgical Interventionsmentioning

confidence: 99%

Recent Advances in the Diagnosis and Management of Herpetic Keratitis

Nowińska¹

2021

Infectious Eye Diseases - Recent Advances in Diagnosis and Treatment

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The chapter is focused on one of the major cause of keratitis - Herpetic keratitis, its epidemiology, natural course, clinical forms, prognosis, diagnosis and treatment. The estimated global incidence of HSV keratitis is roughly 1,5 million, including 40,000 new cases of each year. Patients are usually affected in the early decades of live, therefore the disease has a severe impact on quality of life and quality of vision in young, productive adults. The author describes the detailed corneal characteristics, provides slit lamp photographs, optical coherence tomography scans and confocal microscopy results of different forms of the HSV keratitis: epithelial, stromal, necrotizing and endothelial. The chapter also discusses recent methods of diagnosis based on PCR testing as well as established and future methods of treatment based on the latest research results.

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Predictive factors of Boston Type I Keratoprosthesis outcomes: A long-term analysis

Cited by 12 publications

References 43 publications

Long-term Outcomes of Boston Type I Keratoprosthesis, and Efficacy of Amphotericin B and Povidone-Iodine in Infection Prophylaxis

Long-term Outcomes of Boston Type I Keratoprosthesis, and Efficacy of Amphotericin B and Povidone-Iodine in Infection Prophylaxis

Artificial Cornea: Past, Current, and Future Directions

Recent Advances in the Diagnosis and Management of Herpetic Keratitis

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