BACKGROUND
Main portal vein tumor thrombus (MPVTT), which has a high incidence, is the major complication of terminal liver cancer. The occurrence of MPVTT is always a negative prognostic factor for patients with hepatocellular carcinoma (HCC). Therefore, attention should be paid to the treatment of MPVTT and its complications.
AIM
To evaluate the efficacy of transarterial chemoembolization/transarterial embolization (TACE/TAE)+
125
I seeds implantation with transjugular intrahepatic portosystemic shunt (TIPS) in treating MPVTT and its complications.
METHODS
From January 2007 to March 2015, 85 consecutive patients with MPVTT were nonrandomly assigned to undergo treatment with TACE/TAE + TIPS and
125
I implantation (TIPS-
125
I group) or TACE/TAE + TIPS only (TIPS only group) in Beijing Shijitan Hospital, and all clinical data were collected. During 24 mo follow-up, the incidence of overall survival, stent stenosis and symptom recurrence was analyzed to evaluate the efficacy of TIPS-
125
I.
RESULTS
During 24 mo follow-up of all patients, we collected data at 6, 12 and 24 mo. The rates of survival were 80%, 45%, and 20%, respectively, in the TIPS-
125
I group, whereas those in the TIPS only group were 64.4%, 24.4%, and 4.4%, respectively (
P
< 0.05). The rates of symptom recurrence were 7.5%, 22.5%, and 35%, respectively, in the TIPS-
125
I group, whereas those in the TIPS only group were 31.1%, 62.2%, and 82.2% (
P
< 0.05). The rates of stent restenosis were 12.5%, 27.5%, and 42.5%, respectively, in the TIPS-
125
I group, and 42.2%, 68.9%, and 84.4%, respectively, in the TIPS only group (
P
< 0.05). TIPS-
125
I was found to be significantly favorable in treating MPVTT and its complications in patients with HCC.
CONCLUSION
TACE/TAE+
125
I combined with TIPS is effective in treating MPVTT and its complications, improving quality of life of patients and reducing mortality.