Predictive factors for the progression of primary localized stage small-bowel follicular lymphoma

Sumioka, Akihiko; Oka, Shiro; Hirata, Issei; Iio, Sumio; Tsuboi, Akiyoshi; Takigawa, Hidehiko; Yuge, Ryo; Urabe, Yuji; Boda, Kazuki; Kohno, Tomohiko; Okanobu, Hideharu; Kitadai, Yasuhiko; Arihiro, Koji; Tanaka, Shinji

doi:10.1007/s00535-022-01897-1

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…In particular, with the widespread use of small bowel endoscopy, FL in the jejunum and ileum is more easily detected. 16 Patients with PGI-FL generally lack systemic symptoms, and in most asymptomatic patients, the lesions are incidentally detected during routine oesophagogastroduodenoscopy. 8 From a retrospective multicentre survey in Japan summarizing 125 patients with PGI-FL, scholars reported that 96 patients (76.8%) were asymptomatic.…”

Section: Discussionmentioning

confidence: 99%

“…14,30 According to the FLIPI scores, 52 (87%) patients were at low risk, and eight (13%) patients were at intermediate risk in a recent study. 16 Based on the scores generated by the OS nomogram, we successfully classified patients into three groups (low-, median-and high-risk groups), providing a stratification which may of value to clinicians in personalized treatment.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, we observed an upwards trend in PGI‐FL incidence throughout the last 40 years, with an APC of 1.87% (95% CI 1.22–2.52, p < 0.05), which might be partly due to an increasing awareness of health and the continuous development of endoscopic techniques over time. In particular, with the widespread use of small bowel endoscopy, FL in the jejunum and ileum is more easily detected 16 …”

Section: Discussionmentioning

confidence: 99%

“…Although the follicular lymphoma international prognostic index (FLIPI) and FLIPI2 are well used for risk stratification in nodal FL cases, most patients with primary intestinal follicular lymphoma are classified as low risk or intermediate risk 14,30 . According to the FLIPI scores, 52 (87%) patients were at low risk, and eight (13%) patients were at intermediate risk in a recent study 16 . Based on the scores generated by the OS nomogram, we successfully classified patients into three groups (low‐, median‐ and high‐risk groups), providing a stratification which may of value to clinicians in personalized treatment.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological features and prognosis for primary gastrointestinal follicular lymphoma

Li,

Gao,

Meng

et al. 2024

Br J Haematol

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SummaryPrimary gastrointestinal follicular lymphoma (PGI‐FL) is a rare extra‐nodal lymphoma. Its epidemiology and prognosis remain unclear. We performed a retrospective analysis of eligible patients with 1648 PGI‐FL and 34 892 nodal FL (N‐FL) in the Surveillance, Epidemiology and End Results (SEER) database. The age‐adjusted average annual incidence of PGI‐FL was 0.111/100000. The median overall survival (OS) for PGI‐FL and N‐FL patients was 207 and 165 months respectively. The 5‐year diffuse large B‐cell lymphoma (DLBCL) transformation rates were 2.1% and 2.6% respectively. Age, sex, grade, Ann Arbor stage, primary site and radiation were independent prognostic factors (p < 0.05). Nomograms were constructed to predict 1‐, 5‐ and 10‐year OS and disease‐specific survival (DSS). The receiver operating characteristic curves and calibration plots showed the established nomograms had robust and accurate performance. Patients were classified into three risk groups according to nomogram score. In conclusion, the incidence of PGI‐FL has increased over the past 40 years, and PGI‐FL has a better prognosis and a lower DLBCL transformation rate than N‐FL. The nomograms were developed and validated as an individualized tool to predict survival. Patients were divided into three risk groups to assist clinicians in identifying high‐risk patients and choosing the optimal individualized treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Epidemiological features and prognosis for primary gastrointestinal follicular lymphoma

Li,

Gao,

Meng

et al. 2024

Br J Haematol

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“…However, owing to the rarity of the disease and the limited number of available studies, an accurate estimation of these rates is currently unavailable. Recent research has emphasized that the circumferential location and fusion of follicular lesions are signi cant predictors of disease progression or transformation into diffuse large B-cell lymphoma [10]. Patients with these endoscopic features may require short-term surveillance for close monitoring of their condition.…”

Section: Discussionmentioning

confidence: 99%

Role of Small Bowel Capsule Endoscopy in Determining the Treatment Strategy for Duodenal Follicular Lymphoma: A Single-Center Retrospective Study

Kang,

Min,

Kim

et al. 2024

Preprint

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In this single-center retrospective study, we aimed to verify the extent of duodenal follicular lymphoma (DFL) and investigate the role and clinical significance of video capsule endoscopy (VCE) in this process. We analyzed the clinical and imaging data of 40 patients diagnosed with DFL. Imaging workup and bone marrow biopsies revealed DFL only in the gastrointestinal tract (stage I) in 22 patients and in local lymph nodes (stage II1), distant lymph nodes (stage II2), pancreas (stage II2Epancreas), and extranodal regions (stage IV) in 1, 3, 1, and 13 patients, respectively. Fifteen of the 23 patients with localized (stages I and II1) DFL underwent VCE for comprehensive small bowel evaluation, which revealed lesion extension beyond the duodenum in 10 patients (66.7%). A watch-and-wait strategy was implemented for 1 patient and systemic chemotherapy was administered to the remaining nine. Of the eight patients without VCE, seven and one received radiotherapy and observation, respectively. Nine of the 23 patients (39.1%) received systemic treatment based on positive VCE results. Only one of the 17 patients with advanced-stage DFL (stages II2 and IV) accepted radiotherapy; 16 underwent systemic chemotherapy. During follow-up (median, 48.4 months), two relapse events occurred in the advanced stage, with no lymphoma-associated deaths. DFL tends to be indolent with favorable outcomes. Proactive VCE for diagnosing DFL is recommended to determine small bowel involvement, which may influence subsequent treatment decisions.

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Disease surveillance evaluation of primary small-bowel follicular lymphoma using capsule endoscopy images based on a deep convolutional neural network (with video)

Sumioka

Tsuboi

Oka

et al. 2023

Gastrointestinal Endoscopy

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Predictive factors for the progression of primary localized stage small-bowel follicular lymphoma

Cited by 6 publications

References 33 publications

Epidemiological features and prognosis for primary gastrointestinal follicular lymphoma

Epidemiological features and prognosis for primary gastrointestinal follicular lymphoma

Role of Small Bowel Capsule Endoscopy in Determining the Treatment Strategy for Duodenal Follicular Lymphoma: A Single-Center Retrospective Study

Disease surveillance evaluation of primary small-bowel follicular lymphoma using capsule endoscopy images based on a deep convolutional neural network (with video)

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