Predictive factors for severe placental damage in pregnant women with SARS-CoV-2 infection

An Update on COVID-19-Associated Placental Pathologies

“…These maternal risk factors may result in pre-eclampsia, which is also increased among COVID-19 pregnancies or result in fetal hypoxia and distress due to higher rates of acute respiratory distress syndrome of the mother [5,9,62,63]. But cardiovascular risk factors can be associated with adverse pregnancy outcomes without a specific histomorphological correlate, as diabetes and obesity are not significantly associated with severe placental damage [54].…”

Placental damage in pregnant women with SARS-CoV-2 infection: Comment

“…We would like to share ideas on the publication “Predictive factors for severe placental damage in pregnant women with SARS-CoV-2 infection [ 1 ].” SARS-Cov-2 infection during pregnancy, according to Damman et al, can result in severe placental lesions with significant perivillous fibrin deposition, histiocytic intervillositis, and trophoblast necrosis [ 1 ]. Potential indicators of severe placental lesions are identified by Damman et al in Ref.…”

“…Potential indicators of severe placental lesions are identified by Damman et al in Ref. [ 1 ]. According to Damman et al, the existence of coagulation abnormalities (hypofibrinogenemia and thrombocytopenia), IUGR, and gestational age in these patients was substantially linked with the presence of severe placental lesions caused by SARS-Cov-2 [ 1 ].…”

“…[ 1 ]. According to Damman et al, the existence of coagulation abnormalities (hypofibrinogenemia and thrombocytopenia), IUGR, and gestational age in these patients was substantially linked with the presence of severe placental lesions caused by SARS-Cov-2 [ 1 ]. In order to forecast potential unfavorable fetal outcomes, Damman et al stated that their data encourage laboratory and ultrasound surveillance of these markers in pregnant women with COVID-19, particularly during the second trimester.…”

Before placental damage can be attributed to SARS-CoV-2, alternative causes must be sufficiently ruled out

“…The retrospective study by Damman et al [ 1 ] in 96 placentas from SARS-CoV-2 positive females attributed severe placental lesions in 12 placentas to SARS-CoV-2 and these lesions were significantly associated with the presence of coagulation disorders (hypofibrinogenemia, thrombocytopenia), intrauterine growth retardation (IUGR), and gestational age [ 1 ]. The study is excellent but has limitations that are cause of concerns and should be discussed.…”