Predictive Factors for Pelvic Organ Prolapse in Iranian Women’s, An Ordinal Logistic Approc

Direkvand-Moghadam, Ashraf; Ghazanfari, Zeinab; Sayehmiri, Kourosh

doi:10.7860/jcdr/2014/7261.3970

Cited by 6 publications

(1 citation statement)

References 17 publications

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“…Various research groups have analyzed a range of risk factors for POP including childbirth, birth trauma, menopause, body mass index (BMI) and chronic obstructive pulmonary disease (COPD). 6 , 7 With regards to a genetical predisposition to pelvic floor dysfunction, epidemiological studies carried out on monozygotic twins have highlighted an association between genital prolapse and varicose veins, hiatal and inguinal hernias and hypermobile joint syndrome but an absence of association with environmental factors. 8 , 9 …”

Section: Introductionmentioning

confidence: 99%

Changes in muscularis propria of anterior vaginal wall in women with pelvic organ prolapse

Vetuschi

Sferra

et al. 2016

Eur J Histochem

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The objective of this study was to evaluate the morphological and immunohistochemical alterations of tissue removed from the upper third of anterior vaginal wall in a sample group of the female population presenting homogenous risk factors associated with pelvic organ prolapse (POP). The case study consisted of 14 patients with POP and there were 10 patients in the control group. Patient selection was carried on the basis of specific criteria and all of the patients involved in the study presented one or more of the recognized POP risk factors. Samples were taken from POP patients during vaginal plastic surgery following colpohysterectomy, and from control patients during closure of the posterior fornix following hysterectomy. Samples were processed for histological and immunohistochemical analyses for Collagen I and Collagen III, α-Smooth Muscle Actin (α-SMA), Platelet-Derived-Growth-Factor (PDGF), matrix metalloproteinase 3 (MMP3), tissue inhibitors metalloproteinase 1 (TIMP1), Caspase3. Immunofluorescence analyses for Collagen I and III and PDGF were also carried out. In prolapsed specimens our results show a disorganization of smooth muscle cells that appeared to have been displaced by an increased collagen III deposition resulting in rearrangement of the muscularis propria architecture. These findings suggest that the increase in the expression of collagen fibers in muscularis could probably be due to a phenotypic switch resulting in the dedifferentiation of smooth muscle cells into myofibroblasts. These alterations could be responsible for the compromising of the dynamic functionality of the pelvic floor.

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Section: Introductionmentioning

confidence: 99%

Changes in muscularis propria of anterior vaginal wall in women with pelvic organ prolapse

Vetuschi

Sferra

et al. 2016

Eur J Histochem

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Exploration of sexual experience among women with pelvic organ prolapse: a qualitative study

Hadizadeh-Talasaz

Khadivzadeh

Ghaebi

et al. 2019

Sexual and Relationship Therapy

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Neurovascular alterations of muscularis propria in the human anterior vaginal wall in pelvic organ prolapse

Sferra

Pompili

et al. 2019

Journal of Anatomy

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In the pathophysiology and progression of pelvic organ prolapse (POP), it has been demonstrated that there is a reorganisation of the muscularis propria of the anterior vaginal wall due to a phenotypic smooth muscle cell to myofibroblast switch. An abnormal deposition of collagen type III seems to be influenced by the involvement of advanced glycation end‐products. The aim of the present study was to evaluate the hypothesis that this connective tissue remodelling could also be associated with neurovascular alterations of the muscularis in women with POP compared with control patients. We examined 30 women with POP and 10 control patients treated for uterine fibromatosis. Immunohistochemical analysis, using glial fibrillary acidic protein, S‐100 protein, receptor tyrosine kinase, neurofilament and α‐smooth muscle actin antibodies, was performed. S‐100, receptor tyrosine kinase and neurofilament were also evaluated using Western blot analysis. We observed a decrease in all neurovascular‐tested markers in nerve bundles, ganglia and interstitial cells of Cajal from POP samples as compared with controls. Even if the processes responsible for these morphological alterations are still not known, it is conceivable that collagen III deposition in the anterior vaginal wall affects not only the architecture of the muscle layer but could also modify the intramuscular neurovascularisation and account for an alteration of the neuromuscular plasticity of the layer.

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Predictive Factors for Pelvic Organ Prolapse in Iranian Women’s, An Ordinal Logistic Approc

Cited by 6 publications

References 17 publications

Changes in muscularis propria of anterior vaginal wall in women with pelvic organ prolapse

Changes in muscularis propria of anterior vaginal wall in women with pelvic organ prolapse

Exploration of sexual experience among women with pelvic organ prolapse: a qualitative study

Neurovascular alterations of muscularis propria in the human anterior vaginal wall in pelvic organ prolapse

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