Predictive Factors for Outcome of First Allogeneic Transplant for Elderly Patients With Acute Lymphoblastic Leukemia

Real-world outcomes in elderly ALL patients with and without allogeneic hematopoietic stem cell transplantation: a single-center evaluation over 10 years

“…The main limitations of this study are its retrospective design and the small patient numbers. However, our findings of excellent outcome after allo HCT in EP are supported by a recent publication of EBMT registry data on elderly ALL patients transplanted in first CR, where a 2-year survival of 50% in patients above 70 years was demonstrated [15]. Also, we are aware that our cohort is subject to some selection bias due to limited referral of unfit highly comorbid EP for treatment assessment to our tertiary center.…”

“…Historically, allo HCT was restricted to younger patients (YP) because of concerns about high transplant-related mortality (TRM) in patients older than 60 years. However, it could be shown that outcome can be improved in EP with survival rates of 18 to 48% and TRM rates of 21 to 41% when reduced-intensity conditioning (RIC) is used [12][13][14], which is supported by a recent analysis based on the EBMT registry with 2-year overall survival (OS) of 39 to 53% in transplant-eligible EP above 70 years of age [15].…”