Predictive factors for fundoplication following esophageal atresia repair

Abstract

Background One of the most frequent complications after repair of esophageal atresia (EA) is gastroesophageal reflux disease (GERD). Although GERD‐associated EA is known to often require anti‐reflux surgery, the predicting factors remain unclear. We retrospectively analyzed EA in our institution. Methods Of 65 children with EA treated in our hospital from 1995 to 2018, 45 with Gross C type EA, followed for over 1 year, were enrolled in this study. The patients were divided into fundoplication and non‐fundoplication groups and compared in terms of their clinical features. Results The fundoplication and non‐fundoplication groups included 13 and 32 cases, respectively. On univariate analysis, gestational age, body weight, prenatal diagnosis, polyhydramnios, re‐do surgery, and gap length of the esophagus differed significantly between the groups (P < 0.05). Conclusion Early delivery, low body weight, and a long gap length are, are considered to be risk factors for fundoplication. However, the present study further showed that prenatal diagnosis and polyhydramnios were also significant contributing factors. The presence of a prenatal diagnosis and polyhydramnios may induce preterm delivery, therefore, cases of polyhydramnios due to suspected EA should be managed to prevent early delivery. Better understanding of the postnatal course after surgery is required, especially for prenatal diagnosis cases.

Proton pump inhibitors in esophageal atresia: A systematic review and meta‐analysis

“…We selected a total of 38 reports on the topic that met the criteria selection (Table S1), representing a cumulative 6044 patients with EA 16–53 . Fourteen studies were prospective and 24 were retrospective.…”