“…These can lead to several complications secondary to the disease, including acute and chronic pain, cardiopulmonary disease, central nervous system disease and kidney disease [31][32][33][34] . Among other complications are constant infections, splenic sequestration, acute chest syndrome, stroke, leg ulcer, and the progression of multiple organ degeneration [31][32][33][34] Acute and chronic complications in individuals with SCD have clinical, hematological, and metabolic outcomes that can affect their energy requirements 35,36 , body composition 37 , as well as the quality of life [38][39][40] .…”